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Catalog No.
Product Name
Application
Product Information
Citations
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Polyphenol Oxidase Inhibitor
Cyanidin 3-sophoroside chloride is a potent non-competitive reversible inhibitor of polyphenol oxidase (PPO) and tyrosinase. This compound demonstrates significant anti-browning activity, making it valuable for enhancing the antioxidant capacity of fruits and extending their storage longevity. Additionally, it is of interest in research applications focused on food preservation and antioxidant mechanisms. -
Collagenase Inhibitor
Cyclo(l-Pro-d-Leu) is a potent collagenase inhibitor, extracted from R. atalantica. It is primarily used in research focusing on connective tissue disorders and wound healing, where collagenase activity is a critical factor. Additionally, this compound demonstrates a mild inhibitory effect on tyrosinase, making it valuable for studies related to melanogenesis and skin pigmentation. -
Mushroom Tyrosinase Diphenolase Inhibitor
Tyrosinase-IN-33 is a pyridine-based compound that acts as a potent inhibitor of mushroom tyrosinase diphenolase activity. It effectively reduces enzyme activity, with an IC50 value of 9.0 μM, making it a valuable tool for research into melanogenesis and related disorders. This compound is suitable for studies investigating enzymatic inhibition and the regulation of pigmentation processes. -
Xanthine Oxidase Inhibitor
Purpurogallin is a naturally occurring phenolic compound extracted from Quercus species, exhibiting potent inhibition of xanthine oxidase (XO) with an IC50 value of 0.2 μM. This compound demonstrates significant antioxidant and anti-inflammatory properties, making it valuable for research in oxidative stress and inflammation-related studies. Its ability to modulate XO activity can be leveraged in the investigation of conditions such as gout and hyperuricemia. -
Fungal Meroterpenoid/AChE inhibitor
Territrem B is a fungal meroterpenoid that serves as an irreversible inhibitor of acetylcholinesterase (AChE). It is isolated from Aspergillus terreus and exhibits significant neurotoxic activity. This compound is valuable for studying AChE-related pathways and can aid in the development of therapeutic agents for neurological disorders. -
Cholinesterase Inhibitors; Lupane Derivative; Molecular Modeling; Triterpenoid
3β-Hydroxy-lup-20(29)-en-16-one is a potent dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting a notable selectivity for BChE with an IC50 value of 28.9 μM. This lupane derivative serves as a valuable tool in the study of cholinergic signaling pathways and triterpenoid research. Its inhibitory properties position it as a potential candidate for neurodegenerative disease research applications, particularly in disorders characterized by cholinergic dysregulation. -
Ketone Inhibitor
(Z-LL)2 ketone is a potent ketone inhibitor with an IC50 value of 50 nM. This compound effectively inhibits the processing of the pro-signal peptide, making it a valuable tool in studies of peptide maturation and processing pathways. The biological activity of (Z-LL)2 ketone supports research applications in biochemistry and molecular biology, particularly concerning peptide signaling mechanisms. -
Pdia3/ERp57 activator, STAT3 inhibitor
Diosgenin glucoside, a saponin compound extracted from Tritulus terrestris L., provides neuroprotection by regulating microglial M1 polarization. Diosgenin glucoside protects against spinal cord injury by regulating autophagy and alleviating apoptosis . -
Topoisomerase
(S)-10-Hydroxycamptothecin is a camptothecin derivative that inhibits DNA topoisomerase by enacting strand breaks in chromosomal DNA and inducing apoptosis. -
CDK336 Inhibitor
Pseudolaric Acid A is a diterpene acid isolated from Pseudolarix kaempferi, has antifungal, cytotoxic and antifertile activities. -
HMG-CoA reductase inhibitor
Swertiamarin has shown potential as antiatherogenic agent by inhibiting HMG-CoA reductase activity in high cholesterol fed rats. -
plant growth inhibitor
Dihydroactinidiolide, existing in plant leaves and fruits, is a potent plant growth inhibitor, a regulator of gene expression and is responsible for photo acclimation in Arabidopsis. -
Stat3 inhibitor & Apoptosis inducer
Homoharringtonine is a cephalotaxine alkaloid which inhibits the formation of diphenylalanine and acetylphenylalanyl-puromycin in liver ribosomes. -
ArfGEF inhibitor
Golgicide A is a potent, highly specific, and reversible inhibitor of the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factors (ArfGEF), GBF1. -
CD40-TRAF6 interaction inhibitor
TRAF-STOP inhibitor 6877002, is a selective inhibitor of CD40-TRAF6 interaction, compound VII, shows inhibition of NF-κB activation in RAW cells, extracted from patent WO2014033122A1. -
5-lipoxygenase inhibitor
Esculetin, a phenolic compound, acts as a 5-LO (5-lipoxygenase, 5-LOX) inhibitor. -
BACE1 Inhibitor
Timosaponin B-II is a major active component of Anemarrhena asphodeloides Bunge (Liliaceae, rhizome) that has protective effects against cerebral ischaemic damage. -
Microtubule polymerization inhibitor
Cucurbitacin B, a natural triterpenoid is well-known for its strong anticancer activity, and recent studies showed that the compound inhibits JAK/STAT3 pathway. Also it is an potent Microtubule polymerization inhibitor -
STAT inhibitor
Nitidine chloride, a natural benzophenanthridine alkaloid, has been shown to inhibit cancer growth via induction of cell apoptosis and suppression of cancer angiogenesis. -
Bcl-2 Inhibitor
Acetate gossypol, a polyphenolic compound isolated from cottonseeds, inhibits Bcl-2 by acting as a BH3 mimetic. -
ATPase and GTPase inhibitor
Etidronate Disodium is a bisphosphonate bone resorption inhibitor. -
STAT3 inhibitor
Corylifol A is a phenolic compounds isolated from Psoralea corylifolia; inhibits IL-6-induced STAT3 activation and phosphorylation(IC50=0.8 uM). -
Tyrosinase Inhibitor
Kurarinol is a flavanone extracted from the root of Sophora flavescens that functions as a competitive inhibitor of tyrosinase, exhibiting an IC50 value of 0.1 μM against mushroom tyrosinase. This compound is primarily utilized in research focused on skin pigmentation and related disorders, making it valuable in the study of melanogenesis and potential therapeutic applications in hyperpigmentation. -
NO Production Inhibitor
Anti-inflammatory agent 98 is a potent nitric oxide (NO) production inhibitor, exhibiting an IC50 value of 14.79 μM. This benzofuran compound demonstrates significant anti-inflammatory activity and is derived from the roots of Paeonia lactiflora Pall. It is suitable for research applications focused on inflammation pathways and the modulation of NO-mediated biological processes. -
Aldehyde Reductase Inhibitor
7-O-Methylluteone is an aldehyde reductase inhibitor derived from luteone, characterized by the substitution of a hydroxy group at position 7 with a methoxy group. This compound exhibits significant biological activity by modulating the activity of aldehyde reductase, making it useful in various biochemical applications. Its role as a metabolite further highlights its relevance in metabolic pathways and potential therapeutic research. -
Qo Site Inhibitor
5-n-Heptyl-6-hydroxy-4,7-dioxobenzothiazole is a competitive inhibitor of the Qo site in the cytochrome bc1 complex (cytochrome c oxidoreductase) derived from Saccharomyces cerevisiae. This compound disrupts electron transport in mitochondrial respiration, contributing to its potential as a tool for studying oxidative phosphorylation and mitochondrial dysfunction. Its application extends to investigating bioenergetics and evaluating the effects on cell viability and metabolic processes. -
Cholesterol Biosynthesis Inhibitor
Dihydromonacolin L is a potent inhibitor of cholesterol biosynthesis, derived from a mutant strain of Monascus niger. This compound effectively reduces cholesterol levels by targeting key enzymes involved in the biosynthetic pathway. Dihydromonacolin L is widely used in research focusing on lipid metabolism and the regulation of cholesterol homeostasis. -
Coumarin-glycoside Inhibitor
Decuroside IV is a coumarin-glycoside inhibitor derived from the roots of Peucedanum decursivum Maxim. It effectively inhibits secondary wave aggregation of human platelets triggered by ADP, making it valuable for research into platelet function and aggregation mechanisms. This compound is also relevant in the study of thrombosis and related cardiovascular conditions. -
LOXL2 Inhibitor, EMT Inhibitor
Escin IA is a selective LOXL2 inhibitor that targets epithelial-mesenchymal transition (EMT), effectively suppressing cell invasion, migration, and metastasis in breast cancer models. Derived from the Aesculus chinensis Bunge fruit saponin fraction, it is identified as a key component in mitigating triple-negative breast cancer metastasis. Additionally, Escin IA has potential applications in studying acute inflammation and ethanol-induced gastric mucosal lesions. -
HIV Inhibitor
Sennoside A is an anthraquinone glycoside derived from the senna plant (Cassia angustifolia) that exhibits inhibitory activity against HIV-1. This compound demonstrates an IC50 value of 3.8 μM in preventing HIV-1 replication and effectively inhibits HIV-1 reverse transcriptase-related DNA polymerase and ribonuclease H, with IC50 values of 1.9 μM and 5.3 μM, respectively. Sennoside A serves as a valuable tool in antiviral research, particularly in studies of HIV-1 replication mechanisms and potential therapeutic interventions. -
Bacterial Inhibitor
Allicin (diallyl thiosulfinate) is a potent bacterial inhibitor derived from garlic extracts, primarily responsible for the antimicrobial properties of garlic. It demonstrates significant antimicrobial activity against a wide range of microorganisms, including antibiotic-resistant strains, making it a valuable reagent for research in microbiology and pharmacology. Allicin is commonly utilized in studies investigating natural antibacterial compounds and their mechanisms of action. -
PLA2 Inhibitor
trans-Benzylideneacetone is a selective inhibitor of phospholipase A2 (PLA2) that demonstrates immunosuppressive activity. Derived from the entomopathogenic bacterium Xenorhabdus nematophila, this compound has significant implications for research in inflammation and immune response modulation. Its ability to inhibit PLA2 makes it a valuable tool in studies focusing on phospholipid metabolism and related biological pathways. -
HBV Inhibitor
Catalpol, an iridoid glycoside derived from Rehmannia glutinosa, primarily targets hepatitis B virus (HBV) inhibition. It exhibits a broad range of biological activities including neuroprotection, hypoglycemic effects, anti-inflammatory properties, and antioxidant effects. Additionally, Catalpol demonstrates potential in anti-cancer and anti-spasmodic applications, making it valuable for various research contexts focusing on viral infections and related therapeutic interventions. -
Tyrosinase Inhibitor
Benzylacetone is a potent and reversible inhibitor of tyrosinase, targeting both monophenolase and diphenolase activities with IC50 values of 2.8 mM and 0.6 mM, respectively. This aromatic compound, derived from agarwood, is primarily used in research applications related to pigmentation and enzyme inhibition. Additionally, benzylacetone has been observed to influence appetite and locomotor activity, making it relevant for studies in metabolic processes. -
Bacterial Inhibitor
3,3'-Di-O-methylellagic acid is a bacterial inhibitor derived from Euphorbia adenochlora. It selectively inhibits the development of acid-fastness in mycobacteria without affecting their growth rates. Additionally, this compound exhibits hepatoprotective properties, likely attributed to its antioxidative effects, making it valuable for research in microbial resistance and liver health. -
Parasite Inhibitor
β-Hederin is a saponin derived from Hedera helix L. (Araliaceae) that demonstrates significant antileishmanial activity. It exhibits IC50 values of 1.5 μM against L. mexicana promastigotes, 68 nM against L. mexicana amastigotes, and 4.57 μM in THP-1 cells. This compound may be utilized in research applications targeting leishmaniasis, providing insights into potential therapeutic strategies against parasitic infections. -
HIV Inhibitor
Gomisin G is a lignan derived from Schisandra chinensis that acts as an anti-HIV agent with an EC50 of 0.006 μg/mL. It exhibits anti-liver cancer and anti-inflammatory properties while utilizing an AKT-cyclin D1 dependent mechanism to target triple-negative breast cancer cells by inhibiting phosphorylation rather than promoting apoptosis. Additionally, Gomisin G leads to G1 phase cell cycle arrest and inhibition of AKT phosphorylation. This compound is suitable for research applications focusing on HIV and various cancer types, including breast and liver cancers. -
Glycogen Phosphorylase Inhibitor
Bayogenin is a triterpenoid saponin that primarily acts as an inhibitor of glycogen phosphorylase. This compound is derived from Medicago sativa and is notable for its ability to modulate glycogen metabolism. Bayogenin is utilized in research applications focused on metabolic regulation and the investigation of glycogen-related disorders. -
Tyrosinase Inhibitor
Benzoyloxypaeoniflorin is a potent tyrosinase inhibitor derived from the root of Paeonia suffruticosa, exhibiting an IC50 value of 0.453 mM against mushroom tyrosinase. Additionally, it functions as an NF-κB inhibitor, contributing to enhanced blood circulation by inhibiting platelet aggregation and blood coagulation. This compound is of significant interest in research applications focused on skin disorders and inflammation. -
Cholinesterase (ChE) Inhibitor
Sinapine thiocyanate is a cholinesterase (ChE) inhibitor known for its multifaceted biological activities. This alkaloid, derived from cruciferous plant seeds, exhibits anti-inflammatory, antioxidant, antitumor, anti-angiogenic, and radioprotective properties. Its ability to inhibit acetylcholinesterase (AChE) highlights its potential in research related to neurodegenerative disorders such as Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease. -
HCV Inhibitor
Deapioplatycodin D is a triterpenoid saponin derived from Platycodon grandiflorum, demonstrating effective inhibition of Hepatitis C virus (HCV). This compound shows significant antiviral activity, making it a valuable candidate for research focused on HCV-related medicinal applications and therapeutic development. -
HIV Protease Inhibitor
Ganoderic acid B is a triterpene derived from the medicinal mushroom Ganoderma lucidum, functioning as an inhibitor of HIV protease. This compound exhibits moderate inhibitory activity against HIV-1 protease, with an IC50 value of 170 μM, making it a potential candidate for research into antiviral therapies. Additionally, ganoderic acid B has demonstrated the ability to inhibit Epstein-Barr virus (EBV) antigen activation and may serve as a telomerase inhibitor, highlighting its broad potential in virology and cancer research applications. -
Ferroptosis Inhibitor
Isoeugenol acetate is a ferroptosis inhibitor derived from isoeugenol. This compound has been shown to modulate cell death mechanisms associated with oxidative stress, making it a valuable tool for investigating ferroptosis in various biological contexts. Its applications extend to research in cancer biology, neurodegenerative diseases, and other conditions where ferroptosis plays a critical role. -
Thyroid Peroxidase Inhibitor
Goitrin (S-Goitrin) is a potent inhibitor of thyroid peroxidase, effectively reducing iodine utilization by the thyroid gland. This compound is derived from glucosinolate-myrosinase reactions and is utilized in research concerning thyroid function and pathology. Additionally, Goitrin has demonstrated activity against the H1N1 influenza virus, making it relevant for studies in virology and infectious diseases. -
COX Inhibitor
Hamaudol is a chromone derived from Saposhnikovia divaricata, acting as a potent inhibitor of cyclooxygenase (COX)-1 and COX-2, with IC50 values of 0.30 mM and 0.57 mM, respectively. This compound exhibits significant analgesic and anti-inflammatory properties, making it a valuable tool in research focused on pain relief and inflammation modulation. Hamaudol is suitable for investigations into COX inhibition and related biological pathways. -
Guanine Deaminase Inhibitor
Azepinomycin is a potent inhibitor of guanine deaminase, exhibiting an IC50 value of 4.9 μM. This compound is derived from the Streptomyces toyokaensis strain MF71803 and demonstrates significant anti-tumor activity by disrupting purine metabolism in cancer cells. Azepinomycin serves as a valuable tool in cancer research and exploration of metabolic pathways related to nucleic acid synthesis. -
Plant Growth Inhibitor
Kitamycin A is a plant growth inhibitor derived from Streptomyces sp. K385. It functions by interfering with various physiological processes in plants, ultimately suppressing growth and development. This reagent is primarily utilized in research applications studying plant biology, specifically the mechanisms of growth inhibition and stress response in plants.
