5-n-Heptyl-6-hydroxy-4,7-dioxobenzothiazole

Catalog No.: A94744
Qo Site Inhibitor
5-n-Heptyl-6-hydroxy-4,7-dioxobenzothiazole is a competitive inhibitor of the Qo site in the cytochrome bc1 complex (cytochrome c oxidoreductase) derived from Saccharomyces cerevisiae. This compound disrupts electron transport in mitochondrial respiration, contributing to its potential as a tool for studying oxidative phosphorylation and mitochondrial dysfunction. Its application extends to investigating bioenergetics and evaluating the effects on cell viability and metabolic processes.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description5-n-Heptyl-6-hydroxy-4,7-dioxobenzothiazole is a competitive inhibitor of the Qo site in the cytochrome bc1 complex (cytochrome c oxidoreductase) derived from Saccharomyces cerevisiae. This compound disrupts electron transport in mitochondrial respiration, contributing to its potential as a tool for studying oxidative phosphorylation and mitochondrial dysfunction. Its application extends to investigating bioenergetics and evaluating the effects on cell viability and metabolic processes.
Product Information
Catalog NumA94744
FormulaC14H17NO3S
Molecular Weight279.35
CAS Number611207-02-4
SMILESO=C1C(O)=C(CCCCCCC)C(C2=C1SC=N2)=O
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