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Fig. 1 · Structure
Cat. No.
A14553
CAS No.
305-01-1
Formula
C9H6O4
Mol. Weight
178.14

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6,7-Dihydroxycoumarin

Cat. No. A14553 CAS 305-01-1

5-lipoxygenase inhibitor

Esculetin, a phenolic compound, acts as a 5-LO (5-lipoxygenase, 5-LOX) inhibitor.

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Biological Activity

Target & Activity

Target Activity Value
lipoxygenase

Cellular Effect

Cell Line Activity Value Description Reference
Macrophage IC50 11 μM Antiinflammatory activity in NMRI mouse macrophages assessed as inhibition of A23187-induced PGE2 release by Ellman's method [PMID: 8988605]
Macrophage IC50 18 μM Antiinflammatory activity in NMRI mouse macrophages assessed as inhibition of A23187-induced LTC4 release by Ellman's method [PMID: 8988605]
SK-MEL-28 IC50 0.96 μM Anticancer activity against human SK-MEL-28 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay [PMID: 37197457]
SK-MEL3 IC50 1.7 μM Anticancer activity against human SK-MEL3 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay [PMID: 37197457]
U-937 CC50 107.5 μM Cytotoxicity against human U937 cells after 48 hrs by trypan blue assay [PMID: 22925447]
U-937 IC50 143.1 μM Antiproliferative activity against human U937 cells assessed as incorporation of [3H]-methyl-thymidine after 12 hrs by scintillation counting [PMID: 22925447]
U-937 CC50 194.1 μM Cytotoxicity against human U937 cells by trypan blue assay after 48 hrs [PMID: 18060791]
U-937 IC50 31.33 μM Growth inhibition of human U937 cells by [3H]thymidine incorporation assay [PMID: 18060791]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 305-01-1
Applications 5-lipoxygenase inhibitor
Formula C9H6O4
Molecular Weight 178.14
Synonyms Aesculetin; Cichorigenin
SMILES
C1=CC(=O)OC2=CC(=C(C=C21)O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

SolventReported Solubility
DMSO 32 mg/mL (179.63 mM)
Water Insoluble
Ethanol Insoluble

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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