Catalog No.
Product Name
Application
Product Information
Citations
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PDE Inhibitor
Theophylline sodium glycinate is a potent phosphodiesterase (PDE) inhibitor with significant effects on airway smooth muscle relaxation. It acts primarily by inhibiting PDE3, which contributes to its anti-inflammatory properties through the upregulation of IL-10 and the inhibition of NF-κB translocation into the nucleus. Additionally, Theophylline sodium glycinate has been shown to induce apoptosis. This reagent is valuable for research applications related to asthma and chronic obstructive pulmonary disease (COPD). -
Anti-inflammatory/Anti-tumor/Anti-mite Agent
2′-Hydroxy-5′-methoxyacetophenone is an acetophenone derivative that modulates inflammatory responses primarily through inhibition of the NF-κB signaling pathway. This compound demonstrates significant anti-tumor properties, particularly against ovarian cancer, and exhibits acaricidal activity. Additionally, it effectively inhibits enzymes such as α-amylase, collagenase, and aldose reductase with IC50 values of 0.928 μM, 3.264 μM, and 20.046 μM, respectively, indicating its potential in diabetes research. -
PTEN/NF-κB Inhibitor
Coelonin is a dihydrophenanthrene that functions as a potent PTEN and NF-κB inhibitor. It demonstrates significant anti-inflammatory activity by inhibiting LPS-induced PTEN phosphorylation. Coelonin negatively regulates the PI3K/AKT pathway, leading to decreased NF-κB activation and p27Kip1 degradation. Additionally, it promotes the stabilization of IκBα by inhibiting its phosphorylation and degradation, thereby increasing its expression. This compound is valuable for research applications focused on inflammation and related signaling pathways. -
Anti-inflammatory Analgesic/Anti-tumor/Diuretic Agent
Hecogenin acetate is an orally active steroid saponin aglycone that functions primarily as an anti-inflammatory and analgesic agent. It exerts its biological effects by inhibiting the phosphorylation of NF-κB and p38 MAPK signaling pathways, antagonizing TRPA1/TRPM8 channels, and reducing the production of pro-inflammatory cytokines. Additionally, Hecogenin acetate demonstrates neuroprotective and anti-tumor properties, inhibits reactive oxygen species (ROS) production, and downregulates MMP-2 expression. This compound also enhances gastric mucosal defense and promotes ulcer healing while potentially restoring antibiotic sensitivity when used in combination with specific antibiotics. -
IRAK4 PROTAC Degrader
FIP22 is a potent and selective degrader of IRAK4 utilizing the PROTAC technology. It functions by inducing degradation through the formation of a ternary complex consisting of IRAK4, FIP22, and CRBN, with an EC50 of 12.63 nM. This mechanism effectively inhibits IRAK4-mediated signaling pathways, including NF-κB and MAPK pathways, making FIP22 valuable for research into conditions such as atopic dermatitis, where IRAK4 plays a critical role. -
Stable Isotope
1,4-Naphthoquinone-d6 is the deuterated form of 1,4-Naphthoquinone, a potent inhibitor targeting multiple enzymes including DNA polymerases, NF-κB, and monoamine oxidases (MAO-A/B). It exhibits broad-spectrum biological activity, demonstrating antibacterial properties, anti-biofilm effects, and the ability to inhibit tumor cell proliferation, induce apoptosis, and promote necrosis. Additionally, 1,4-Naphthoquinone-d6 has applications in research focused on anti-tumor and anti-inflammatory mechanisms, particularly in melanoma and colon cancer cell studies, as well as LPS-induced inflammation models. Its role in oxidative stress induction and glutathione depletion further supports its potential in diverse therapeutic investigations. -
Mulberroside A Cis-isomer
cis-Mulberroside A is the cis-isomer of Mulberroside A, a principal bioactive compound found in mulberry (Morus alba L.). This compound exhibits anti-inflammatory activity by downregulating the expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, while also inhibiting NALP3 activation, caspase-1, and NF-κB pathways, alongside the phosphorylation of ERK, JNK, and p38. Additionally, cis-Mulberroside A demonstrates inhibitory activity against mushroom tyrosinase with an IC50 value of 53.6 μM, making it valuable for research in inflammation and pigmentation disorders. -
CD40 Inhibitor
KGYY15 is a CD40-targeting peptide that specifically functions as a CD40 inhibitor, exhibiting a weak inhibition of the CD40-CD40L interaction with an IC50 of over 1 mM. At a concentration of 100 μM, KGYY15 can activate the NF-κB pathway by approximately 33%. This compound is valuable for research applications aimed at understanding the modulation of immune responses and investigating the role of CD40 signaling in various biological contexts. -
Apoptosis Inducer
Crebanine is an isoquinoline-like alkaloid that acts as an apoptosis inducer through antagonism of the α7-nAChR, exhibiting an IC50 value of 19.1 μM. This compound suppresses cancer cell proliferation, migration, and invasion while triggering a reactive oxygen species (ROS) burst that promotes apoptosis. Additionally, Crebanine modulates critical signaling pathways including AKT/FoxO3a, NF-κB, and MAPK, and demonstrates antioxidant properties in microglia by reducing ROS and lipid peroxidation. With applications in studying hepatocellular carcinoma, cerebral ischemia, and Alzheimer's disease, Crebanine may also ameliorate cognitive deficits and ischemia-reperfusion brain damage in rodent models. -
CD40-CD40L Blocker
DRI-C25441 is a potent inhibitor of the CD40-CD40L interaction, demonstrating an IC50 value of 0.36 μM. This compound effectively suppresses immune responses triggered by alloantigens and inhibits CD40L-induced activation of the NF-κB signaling pathway. DRI-C25441 is commonly utilized in research related to immune disorders, making it a valuable tool for elucidating mechanisms of immune regulation. -
Antibiotic
Ceftiofur sodium is an antibiotic that acts as a cell wall synthesis inhibitor by targeting bacterial penicillin-binding proteins (PBPs). It exhibits bactericidal activity through the inhibition of peptidoglycan synthesis, resulting in bacterial cell lysis. Additionally, Ceftiofur sodium has anti-inflammatory properties by inhibiting the activation of NF-κB and MAPKs, which decreases the secretion of pro-inflammatory cytokines including TNF-α, IL-1β, and IL-6. This compound is applicable in research related to antibiotic resistance and inflammatory responses. -
TNF-α Inhibitor
IA-14069 is an orally active inhibitor of tumor necrosis factor-α (TNF-α), directly targeting TNF-α and interfering with TNF-α-mediated signaling pathways, including p-IκBα and NF-κB p65 activities. This compound demonstrates a suppressive effect on Dextran sodium sulfate (DSS)-induced colitis, making it valuable for research into inflammatory conditions. IA-14069 is particularly relevant for studies focused on rheumatoid arthritis (RA) and inflammatory bowel disease (IBD). -
ACE Inhibitor
Fosfenopril is a potent angiotensin-converting enzyme (ACE) inhibitor. It exhibits anti-inflammatory properties by reducing lipopolysaccharide (LPS)-induced inflammation through the inhibition of TLR4/NF-κB signaling pathways in monocytes. This compound is valuable for research applications focused on cardiovascular diseases, inflammation, and the modulation of the immune response. -
RIPK1 PROTAC Degrader
R1-ICR-5 is a selective RIPK1 PROTAC degrader designed to mediate protein degradation via the VHL pathway. This compound promotes the degradation of RIPK1, subsequently dysregulating TNFR1 and TLR3/4 signaling pathways, enhancing the activity of NF-κB, MAPK, and IFN signaling. Additionally, R1-ICR-5 facilitates RIPK3 activation, leading to necroptosis. This reagent is applicable in research focused on triple-negative breast cancer and skin inflammation. -
Stable Isotope
Tris(2-chloroethyl)phosphate-d12 is a deuterium-labeled derivative of Tris(2-chloroethyl) phosphate, primarily utilized as a stable isotope in biological research. This compound serves as an organic phosphorus flame retardant and plasticizer, exhibiting hepatotoxicity through mechanisms such as increased reactive oxygen species (ROS) production, calcium ion influx, and mitochondrial membrane potential reduction. Additionally, it influences the TLR4/NF-κB signaling pathway, leading to liver inflammation and the development of obesity and fatty liver in experimental models. Tris(2-chloroethyl)phosphate-d12 is integral for studies focused on metabolic disorders and toxicity assessments. -
cAMP Agonist
Undecane is a potent cAMP agonist known for its anti-allergic and anti-inflammatory properties. It effectively inhibits degranulation and the release of key inflammatory mediators such as histamine and TNF-α. Additionally, undecane reverses the phosphorylation of p38, modulates NF-κB transcriptional activity, and targets cytokine and chemokine gene expression, including TARC, MDC, and IL-8. This compound is valuable for investigations into skin inflammatory disorders, particularly atopic dermatitis. -
PDE Inhibitor
Theophylline monohydrate is a potent phosphodiesterase (PDE) inhibitor that primarily targets PDE3, promoting relaxation of airway smooth muscle. This compound exhibits anti-inflammatory properties by increasing interleukin-10 (IL-10) levels and inhibiting the nuclear translocation of NF-κB. Additionally, Theophylline monohydrate is known to induce apoptosis in certain cell types. It is widely utilized in research related to asthma and chronic obstructive pulmonary disease (COPD). -
Apoptosis Inducer
Alphitolic acid, an apoptosis inducer, is a triterpene isolated from Quercus aliena. It functions by inhibiting Akt–NF-κB signaling pathways, promoting apoptosis and autophagy. Additionally, Alphitolic acid exhibits anti-inflammatory properties by down-regulating nitric oxide and TNF-α production. This compound is applicable in cancer and inflammation research. -
Anti-Inflammatory Agent
Kaempferol 3-O-sophoroside is an anti-inflammatory agent that functions primarily by inhibiting the toll-like receptors TLR2 and TLR4 associated with High mobility group box 1 (HMGB1). This compound displays notable anti-inflammatory and analgesic properties, primarily through the inhibition of NF-κB activation and the subsequent reduction of TNF-α production. Additionally, it promotes the synthesis of brain-derived neurotrophic factor (BDNF) and enhances autophagy via AMP-activated protein kinase (AMPK) activation, contributing to its antidepressant effects. Kaempferol 3-O-sophoroside is a valuable tool for research focused on inflammation and neurodegenerative diseases. -
CHIKV Virus Inhibitor
Ethyl palmitate, also known as Ethyl hexadecanoate, functions as a CHIKV virus inhibitor, exhibiting an EC50 value of 0.0068 μM. This compound has demonstrated the ability to reduce pro-inflammatory cytokines such as TNF-α and IL-6, along with downregulating NF-κB in endotoxemic rat models, indicating its potential for anti-inflammatory applications. Ethyl palmitate serves as a valuable tool for research in virology and inflammation-related studies. -
Anti-inflammatory Agent
Edpetiline is an anti-inflammatory agent that targets the inhibition of IκB phosphorylation, thereby preventing the nuclear translocation of NF-κB p65. This compound also inhibits p38 MAPK and ERK MAPK phosphorylation, leading to reduced intracellular ROS levels. Furthermore, Edpetiline downregulates pro-inflammatory cytokines such as TNF-α, IL-6, iNOS, and COX-2 while promoting the expression of the anti-inflammatory cytokine IL-4. It is suitable for research into conditions related to inflammation and oxidative stress. -
Phosphodiesterase 4 Inhibitor
Tanimilast is a selective phosphodiesterase 4 inhibitor that exhibits potent activity with an IC50 of 0.026 nM. By increasing intracellular cAMP levels, Tanimilast effectively disrupts the NF-κB signaling pathway, leading to significant anti-inflammatory effects. This compound is particularly applicable in the study of obstructive lung diseases, making it a valuable tool for research in pulmonary health and related therapies. -
MMP Inhibitor
Ecliptasaponin A is a pentacyclic triterpenoid saponin that functions as a robust inhibitor of matrix metalloproteinases (MMPs). It demonstrates significant anti-tumor properties by activating the ASK1/JNK pathway, leading to apoptosis and autophagy in lung cancer cells. Additionally, Ecliptasaponin A exerts anti-inflammatory and anti-fibrotic effects by inhibiting the HMGB1/TLR4/NF-κB signaling pathway, impacting COX-2 and MMP-9 expression. Its chondroprotective effects are attributed to the downregulation of MMP13 and modulation of inflammatory factors, while it also promotes ovarian function by enhancing ESR1 receptor expression. -
Chloride Channel Inhibitor
Shikonin is a potent inhibitor of the TMEM16A chloride channel, exhibiting an IC50 value of 6.5 μM. This compound functions as a specific inhibitor of pyruvate kinase M2 (PKM2) and also modulates inflammatory pathways by inhibiting TNF-α and NF-κB activation. In addition, Shikonin decreases exosome secretion by impairing glycolytic processes and effectively inhibits AIM2 inflammasome activation. Its diverse activities make it a valuable reagent for investigating cellular signaling and inflammatory responses in research applications. -
NF-κB Inhibitor
Malvidin-3-glucoside chloride is an orally active NF-κB inhibitor, primarily targeting inflammatory pathways induced by TNF-α. It effectively decreases IκB-α degradation and p65 nuclear translocation, consequently enhancing endothelial nitric oxide synthase (eNOS) activity and nitric oxide production. This compound exhibits significant anti-inflammatory and antioxidant properties by suppressing pro-inflammatory molecules such as MCP-1, ICAM-1, and IL-6, while also regulating intestinal microbiota and metabolites. Malvidin-3-glucoside chloride serves as a valuable tool for researching chronic inflammatory diseases, including atherosclerosis and inflammatory bowel disease, with potential applications in preventing vascular inflammation and promoting intestinal health. -
Flame-retardant Plasticizer
Tris(2-chloroethyl) phosphate (TCEP) is an organic phosphorus compound that functions primarily as a flame-retardant plasticizer. It exhibits hepatotoxic effects characterized by an increase in reactive oxygen species (ROS) and calcium ion influx, leading to mitochondrial membrane potential disruption, DNA damage, and programmed cell death. TCEP has been shown to directly interact with the farnesoid X receptor (FXR), promoting obesity and fatty liver development in murine models. Additionally, TCEP activates the TLR4/NF-κB signaling pathway, contributing to liver inflammation, making it relevant for studies on metabolic disorders and toxicology. -
Metabolite of Vitamin C
L-Threonic acid magnesium, a metabolite of vitamin C, acts as a magnesium supplement that enhances brain magnesium levels. It is known to inhibit the TNF-α/NF-κB signaling pathway, making it relevant for research in neuroinflammatory conditions. This compound is particularly notable in studies related to Alzheimer’s disease and is bioavailable when administered orally. -
Amylase Substrate
Maltotetraose is a carbohydrate compound that serves as a substrate for enzyme-linked assays to measure amylase activity in biological fluids. Its primary biological activity includes the reduction of TNF-α-induced inflammatory responses through inhibition of NF-κB activity and decreased expression of ICAM-1. Additionally, maltotetraose inhibits PDGF-induced vascular smooth muscle cell migration and neovascularization. Its derivatives can also be utilized as probes for detecting bacterial infections by targeting the maltodextrin transporter, making maltotetraose a valuable tool in research related to atherosclerosis and inflammatory diseases. -
LT Inhibitor
Tryptanthrin is a potent inhibitor of leukotriene (LT) biosynthesis, targeting the inflammatory pathways involved in various diseases. This indole quinazoline compound exhibits significant anticancer properties by suppressing the expression of key inflammatory mediators such as NOS1, COX-2, and NF-κB. Additionally, Tryptanthrin modulates cytokine levels, influencing the expression of IL-2, IL-10, and TNF-α, making it a valuable reagent for research applications in inflammation and cancer biology. -
Pyrimidine Heterocyclic Compound
3-Methyluracil is a pyrimidine heterocyclic compound that exhibits anti-inflammatory activity. It is known to inhibit Luciferase activity induced by NF-κB and AP-1, leading to a reduction in the mRNA levels of COX-2 and TNF-α. This compound is valuable for research focused on inflammatory diseases and cellular signaling pathways involved in inflammation. -
TLR1/TLR2 Agonist
Diprovocim is a potent TLR1/TLR2 agonist that activates immune responses by inducing full agonist activity in human THP-1 cells, with an EC50 of 110 pM. This compound effectively stimulates TNF-α release from mouse macrophages at an EC50 of 1.3 nM. By activating downstream signaling pathways, including MAPK and NF-κB, Diprovocim demonstrates significant adjuvant activity in mice, enhancing cellular immune responses and making it a valuable tool for immunological research. -
MAO-A/B Inhibitor
1,4-Naphthoquinone serves as a potent inhibitor targeting monoamine oxidase A and B (MAO-A/B) with competitive inhibition of MAO-B (Ki=1.4 μM) and non-competitive inhibition of MAO-A (Ki=7.7 μM). This compound exhibits broad-spectrum biological activity, inhibiting various DNA polymerases alongside notable anti-tumor, anti-inflammatory, and antibacterial properties. Its mechanism includes the induction of oxidative stress, glutathione (GSH) depletion, suppression of DNA synthesis, and blockage of NF-κB nuclear translocation. 1,4-Naphthoquinone is applicable in research involving melanoma and colon cancer cell growth, endothelial cell function, and models of lipopolysaccharide (LPS)-induced inflammation. -
HDAC4 Inhibitor
HDAC-IN-2 is a selective inhibitor of histone deacetylase 4 (HDAC4) with a notable affinity for Class IIa enzymes. This compound is a valuable research tool for the investigation of epigenetic regulation and the modulation of gene expression. It is particularly suitable for high-throughput screening applications and can aid in the development of novel therapeutic strategies targeting HDAC-mediated pathways. -
p300 Histone Acetylatransferase Inhibitor
Curcumin, a natural phenolic compound, functions as a specific inhibitor of the p300/CREB-binding protein histone acetyltransferase. It effectively represses the acetylation of both histone and nonhistone proteins, thereby modulating chromatin transcription. Curcumin exhibits significant biological activities, including anti-inflammatory, antioxidant, antiproliferative, and antiangiogenic effects, while also inhibiting NF-κB and MAPKs. Additionally, it promotes stabilization of the Nrf2 protein through modification of Keap1 cysteines, making it valuable for research in diverse therapeutic contexts. -
HDAC6 Inhibitor
HDAC6-IN-39 is a potent inhibitor of histone deacetylase 6 (HDAC6) with an IC50 of 0.0096 μM. By selectively targeting HDAC6, this compound modulates protein acetylation levels, influencing various cellular processes including protein aggregation and autophagy. HDAC6-IN-39 is useful in research focused on neurodegenerative diseases, cancer therapy, and the regulation of immune responses. -
HDAC Inhibitor
Martinostat is a hydroxylated dialkylcarbamate compound that functions as a histone deacetylase (HDAC) inhibitor. It exhibits significant biological activity by altering acetylation levels, which can influence gene expression and cellular responses. This reagent has applications in the study of neurological disorders and cancer, as well as potential use in quantitative imaging of HDAC activity in vivo across various tissues, including the central nervous system and major peripheral organs. -
HDAC Inhibitor
YF438 is a potent histone deacetylase (HDAC) inhibitor that exhibits significant anti-cancer activity both in vitro and in vivo. It effectively impedes the growth and metastasis of triple-negative breast cancer (TNBC) cells by disrupting the interaction between HDAC and MDM2, leading to the dissociation of MDM2-MDMX complexes and promoting MDM2 degradation. This compound is valuable for research focused on cancer biology and the development of targeted therapies for aggressive tumor types. -
HDAC inhibitor
KBH-A42 is a potent histone deacetylase (HDAC) inhibitor that exhibits notable anti-inflammatory activity. It effectively reduces TNF-α and nitric oxide (NO) production in LPS-induced murine macrophage RAW 264.7 cells, demonstrating IC50 values of 1.10 µM and 2.71 µM, respectively. This compound is valuable for research applications focused on inflammation and related signaling pathways. -
HDAC Inhibitor
BRD4097 is a potent inhibitor of histone deacetylases (HDACs), particularly targeting HDAC1, 2, and 3. By employing metal chelation and spatial rejection mechanisms, BRD4097 effectively modulates HDAC activity, leading to alterations in gene expression and chromatin structure. This compound is valuable for investigating the role of HDACs in cholesterol metabolism and Niemann-Pick C1 (NPC1) disease models. -
HDAC Inhibitor x
(Rac)-Nanatinostat is a potent histone deacetylase (HDAC) inhibitor, exhibiting an IC50 of <330 nM. This compound demonstrates significant anticancer activity, effectively inhibiting cell growth in various cancer cell lines, including HeLa, U937, and HUT cells. It serves as a valuable tool for researching the role of HDACs in cancer biology and potential therapeutic applications in oncology. -
HDAC Inhibitor
MD 85 is a potent histone deacetylase (HDAC) inhibitor with an EC50 of 5 μM. It effectively modulates epigenetic regulation by inhibiting HDAC activity, which can lead to altered gene expression. MD 85 is primarily utilized in cancer research to explore mechanisms of tumorigenesis and potential therapeutic strategies. -
HDAC8 Inhibitor
J1075 is a selective inhibitor of the histone deacetylase 8 (HDAC8) enzyme in Schistosoma mansoni, exhibiting reduced affinity for human HDAC8. This compound has been shown to induce apoptosis and cell death in schistosome cells. J1075 serves as a valuable tool in the investigation of anti-parasitic agents, contributing to the understanding of therapeutic strategies against schistosomiasis. -
BET/HDAC Inhibitor
TW9 is a potent dual inhibitor that targets bromodomain and extraterminal (BET) proteins and histone deacetylases (HDAC) with KDs of 0.069 μM and 0.231 μM for BRD4(1) and BRD4(2), respectively, and an IC50 of 0.29 μM for HDAC1. This compound is a novel derivative of the BET inhibitor (+)-JQ1 and the class I HDAC inhibitor CI994. TW9 demonstrates significant anti-tumor activity in pancreatic ductal adenocarcinoma (PDAC) and enhances the efficacy of the chemotherapeutic agent Gemcitabine, making it a valuable tool for cancer research applications. -
HDACi
ZYJ-25e is a potent histone deacetylase inhibitor (HDACi) that selectively targets HDAC6 and HDAC8, exhibiting IC50 values of 0.047 μM and 0.139 μM, respectively. As a tetrahydroisoquinoline-bearing hydroxamic acid analogue, ZYJ-25e demonstrates significant antitumor efficacy in the MDA-MB231 xenograft model. This compound is valuable for research applications exploring the role of HDAC inhibition in cancer therapeutics. -
JAK/HDAC Inhibitor
JAK/HDAC-IN-3 is a dual inhibitor targeting Janus kinase (JAK) and histone deacetylases (HDAC). It exhibits potent inhibitory activity with IC50 values of 25.36 nM for JAK2, and 0.2 μM and 0.43 μM for HDAC and HDAC1, respectively. This compound is valuable for investigating the roles of JAK and HDAC pathways in cellular processes and disease models, particularly in cancer and inflammatory research. -
HDAC Inhibitor
J27644 is a potent inhibitor of histone deacetylases (HDACs), demonstrating efficacy in mitigating TGF-β-induced pulmonary fibrosis. This compound not only modulates histone acetylation but also influences cellular pathways associated with fibrosis, making it a valuable tool for studying mechanisms underlying fibrotic diseases. Its unique profile supports research applications aimed at elucidating the role of HDACs in various pathological conditions. -
HDAC Inhibitor
HDAC/BET-IN-1 is a potent inhibitor of histone deacetylases HDAC1 and HDAC6, with IC50 values of 0.163 μM and 0.067 μM, respectively. Additionally, it targets BRD4 with a Ki of 0.076 μM. This compound demonstrates significant antileukemia activity, making it a valuable tool for studying epigenetic regulation and potential therapeutic applications in leukemia research. -
HDAC8/PGNGdacs Inhibitor
NHNB is a selective inhibitor of histone deacetylase 8 (HDAC8) and Peptidoglycan N-acetylglucosamine deacetylases (PGNGdacs), with an IC50 value of 66.0 μM. This compound exhibits significant antibacterial and bactericidal activity against Bacillus anthracis and Bacillus cereus. NHNB is particularly useful in research related to acute myeloid leukemia and infections caused by these pathogenic bacteria. -
HDAC6 Inhibitor
HDAC6-IN-71 is a selective inhibitor of histone deacetylase 6 (HDAC6), exhibiting an IC50 of 13.68 nM for HDAC6 and 443.12 nM for HDAC1. This compound effectively reduces nitric oxide production in mouse macrophages, with an IC50 of 2.31 μM. By inhibiting the HDAC6-NF-κB signaling pathway, HDAC6-IN-71 leads to decreased phosphorylation of IκB-α and IKK-α/β, and downregulates the expression of key inflammatory mediators such as COX-2 and iNOS. Its efficacy has been demonstrated in models of ulcerative colitis, highlighting its potential for therapeutic applications in inflammatory diseases. -
HDAC6 Inhibitor
HDAC6-IN-14 is a selective inhibitor of histone deacetylase 6 (HDAC6), exhibiting an IC50 of 42 nM. This compound demonstrates over 100-fold selectivity against HDAC1, HDAC2, HDAC3, and HDAC4. HDAC6-IN-14 is utilized in research focused on cellular processes related to neurodegenerative diseases, cancer, and immunological responses, making it a valuable tool for studying histone acetylation and its effects on gene expression.
