ZYJ-25e is a potent histone deacetylase inhibitor (HDACi) that selectively targets HDAC6 and HDAC8, exhibiting IC50 values of 0.047 μM and 0.139 μM, respectively. As a tetrahydroisoquinoline-bearing hydroxamic acid analogue, ZYJ-25e demonstrates significant antitumor efficacy in the MDA-MB231 xenograft model. This compound is valuable for research applications exploring the role of HDAC inhibition in cancer therapeutics.
ZYJ-25e is a potent histone deacetylase inhibitor (HDACi) that selectively targets HDAC6 and HDAC8, exhibiting IC50 values of 0.047 μM and 0.139 μM, respectively. As a tetrahydroisoquinoline-bearing hydroxamic acid analogue, ZYJ-25e demonstrates significant antitumor efficacy in the MDA-MB231 xenograft model. This compound is valuable for research applications exploring the role of HDAC inhibition in cancer therapeutics.
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