cis-Mulberroside A is the cis-isomer of Mulberroside A, a principal bioactive compound found in mulberry (Morus alba L.). This compound exhibits anti-inflammatory activity by downregulating the expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, while also inhibiting NALP3 activation, caspase-1, and NF-κB pathways, alongside the phosphorylation of ERK, JNK, and p38. Additionally, cis-Mulberroside A demonstrates inhibitory activity against mushroom tyrosinase with an IC50 value of 53.6 μM, making it valuable for research in inflammation and pigmentation disorders.
cis-Mulberroside A is the cis-isomer of Mulberroside A, a principal bioactive compound found in mulberry (Morus alba L.). This compound exhibits anti-inflammatory activity by downregulating the expression of pro-inflammatory cytokines TNF-α, IL-1β, and IL-6, while also inhibiting NALP3 activation, caspase-1, and NF-κB pathways, alongside the phosphorylation of ERK, JNK, and p38. Additionally, cis-Mulberroside A demonstrates inhibitory activity against mushroom tyrosinase with an IC50 value of 53.6 μM, making it valuable for research in inflammation and pigmentation disorders.
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