Other inhibitors

Diosmetin is an O-methylated flavone, a chemical compound that can be found in the Caucasian vetch.

Ribitol is a crystalline pentose alcohol formed by the reduction of ribose.

Nobiletin is a chemical compound. It is an O-methylated flavone, a flavonoid isolated from citrus peels like in tangerine. Nobiletin was found to have anti-inflammatory and anti-tumor invasion, proliferation, and metastasis in vitro and in vivo. Nobiletin was also found to potentially inhibit cartilage degradation.

Betamethasone is a potent glucocorticoid steroid with anti-inflammatory and immunosuppressive properties.

Rutin is one of the phenolic compounds found in the invasive plant species Carpobrotus edulis and contributes to the antibacterial and antioxidant properties of the plant

Ioversol is low osmolality, nonionic, radiographic contrast agent.

Iopamidol is a non-ionic, water-soluble radiographic contrast agent.

Theobromine(3,7-Dimethylxanthine) is a xanthine alkaloid that is used as a bronchodilator and as a vasodilator. It has a weaker diuretic activity than theophylline and is also a less powerful stimulant of smooth muscle. It has practically no stimulant effect on the central nervous system. It was formerly used as a diuretic and in the treatment of angina pectoris and hypertension.

Cefdinir is a third generation oral cephalosporin antibiotic.

Crotamiton is a drug that is used both as a scabicidal (for treating scabies) and as a general antipruritic (anti-itching drug).

Pristinamycin is an antibiotic used primarily in the treatment of staphylococcal infections, and to a lesser extent streptococcal infections.

Oxacillin sodium monohydrate is an antibacterial agent and is a narrow spectrum beta-lactam antibiotic of the penicillin class.

Meropenem is a β-lactam antibiotic of the carbapenem subclass that has been shown to inhibit penicillinase-negative, -positive and methicillin-susceptible staphylococci.

Vancomycin is a glycopeptide antibiotic used in the prophylaxis and treatment of infections caused by Gram-positive bacteria

Rifapentine is an antibiotic drug used in the treatment of tuberculosis.

5-BrdU is a synthetic thymidine analog; incorporated into DNA during replication. Used in assays for cell proliferation.

Dihydroartemisinin is the active metabolite of all artemisinin compounds (artemisinin, artesunate, artemether, etc.) and is also available as a drug in itself. It is a semi-synthetic derivative of artemisinin and is widely used as an intermediate in the preparation of other artemisinin-derived antimalarial drugs.

Paroxetine is an antidepressant drug of the SSRI type.

Ecdysone is a steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone, which is secreted from the prothoracic glands.

Haematoxylin is extracted from the heartwood of the logwood tree.When oxidized it forms haematein, a compound that forms strongly coloured complexes with certain metal ions, the most notable ones being Fe(III) and Al(III) salts. Metal-haematein complexes are used to stain cell nuclei prior to examination under a microscope.

Zanamivir is a neuraminidase inhibitor used in the treatment and prophylaxis of influenza caused by influenza A virus and influenza B virus.

Streptozotocin (Streptozocin, Zanosar, STZ)is used in medical research to produce an animal model for Type 1 diabetes, which directly inhibist the O-GlcNAcase activity of the enzyme NCOAT in vitro.

Sinomenine(Cucoline) is traditionally used in herbal medicine in these countries, as a treatment for rheumatism and arthritis.

Tirapazamine is a bioreductive, anti-neoplastic, anti-cancer agent that is selectively toxic to cells under hypoxic conditions.

AdipoRon is a novel small-molecule AdipoR agonist; binds to both AdipoR1(Kd= 1.8 uM) and AdipoR2(Kd=3.1 uM). IC50 value: 1.8/3.1 uM(AdipoR1/2, Kd)

Osthole(Osthol) is a type of coumarin.

LR-90 is an advanced glycation end product (AGE) inhibitor, inhibits inflammatory responses in human monocytes. LR-90 is also used in the research of diabetic animal model.

RP 54275 (2-Octadecyl-1H-indole-5-carboxylic acid) is a novel hypocholesterolaemic drug.

Ipenoxazone is a potent and centrally acting muscle relaxant.

Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed.

Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity.

Emixustat, a novel visual cycle modulator, is an inhibitor of the visual cycle isomerase with an IC50 value of 4.4 nM in vitro.

nipradilol is an alpha(1),beta-blocker with a nitric oxide donative action

Nalbuphine is a semi-synthetic opioid agonist-antagonist analgesic of the phenanthrene series

CHIR-090 is a potent, slow, tight-binding inhibitor of the LpxC deacetylase. It binds to E. coli LpxC with a Ki of 4.0 nM.

Stiripentol is an epilepsy drug. It has been used as co-therapy for treatment of epilepsy

Benperidol has been used in trials studying the treatment of Dementia, Depression, Schizophrenia, Anxiety Disorders, and Psychosomatic Disorders, among others.

WF-11899A is a novel antifungal lipopeptide antibiotics were isolated from the culture broth of Coleophoma empetri F-11899

AVE5688 is an inhibitor of glycogen phosphorylase (GP), with IC50s of 430 nM and 915 nM and Kds of 170 nM and 530 nM for rabbit muscle glycogen phosphorylase (rmGPb and rmGPa, respectively); AVE5688 can be used for the research of type 2 diabetes.

RGH-5526 (GYKI-11679) is a new antihypertensive agent.

UK-157147 is a substrate for UDP-glucuronosyltransferases (UGT1A1) with a Km value of 105 μM.

Mepixanox (Pimexone) is an analeptic drug used in respiratory and cardiorespiratory insufficiency.

20-HEDE (WIT 002) is an antagonist of 20-hydroxyeicosatetraenoic acid (20-HETE).

Pirazolac is a non-steroidal anti-inflammatory drug.

Prifuroline is an antiarrhythmic agent.

Pirozadil is a hypolipidemic agent.

(±)-WS75624B is an endothelin converting enzyme (ECE) inhibitor with an IC50 of 0.03 μg/mL.

Clozic is a potential anti-arthritic agent.

Tepilamide fumarate (XP-23829) is an oral fumaric acid ester, acts as a prodrug of monomethyl fumarate, and is used in the research of moderate to severe chronic plaque psoriasis.

Tirasemtiv amplifies skeletal muscle response to nerve activation in humans.