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Streptozotocin (Zanosar)

Catalog No.: A10868

O-GlcNAcase inhibitor

Streptozotocin (Zanosar)

Streptozotocin (Zanosar) Chemical Structure

CAS NO. 18883-66-4

Streptozotocin (Streptozocin, Zanosar, STZ)is used in medical research to produce an animal model for Type 1 diabetes, which directly inhibist the O-GlcNAcase activity of the enzyme NCOAT in vitro.

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Package Price Qty
500 mg
1000 mg
10mM * 1mL in DMSO
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Warning WARNING: Attention California Residents: This product can expose you to chemicals including Streptozotocin (Zanosar) , which is known to the State of California to cause cancer and birth defects or other reproductive harm. For more information, go to
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Andressa Braga, .et al. Free interstitial levels of metformin in the liver of healthy and diabetic Wistar rats, Braz J Pharm Sci, 2022, 58: e19674
  • Yuanyuan Du, .et al. Human pluripotent stem-cell-derived islets ameliorate diabetes in non-human primates, Nat Med, 2022, Feb;28(2):272-282 PMID: 35115708
  • Karemah A. Alatawi, .et al. Coconut products alleviate hyperglycaemic, hyperlipidimic and nephropathy indices in streptozotocin-induced diabetic wistar rats, Saudi Journal of Biological Sciences, 2021, 25 June
  • D.H. Mhya, .et al. Evaluation of Anti-hyperglycemic Effect of Sub-fractions Derived from Ethanol-aqueous Fraction of Balanites aegyptiaca Leaves in Streptozotocin-induced Diabetic Rats, Asian J Exp Biol Sci, 2019, 12 (2): 164-172
  • Stanley I. R. Okoduwa, .et al. Validation of the antidiabetic effects of Vernonia amygdalina delile leaf fractions in fortified diet-fed streptozotocin-treated rat model of type-2 diabetes, J Diabetol, 2017, 8(3): 74-85
  • Stanley I. R. Okoduwa, .et al. Anti-Diabetic Potential of Ocimum gratissimum Leaf Fractions in Fortified Diet-Fed Streptozotocin Treated Rat Model of Type-2 Diabetes, Medicines (Basel), 2017, Dec; 4(4): 73 PMID: 29019956
  • Stanley I. R. Okoduwa, .et al. Appropriate Insulin Level in Selecting Fortified Diet-Fed, Streptozotocin-Treated Rat Model of Type 2 Diabetes for Anti-Diabetic Studies, PLoS One, 2017, 12(1): e0170971 PMID: 28129400
  • Stanley I. R. Okoduwa, .et al. Evaluation of extraction protocols for anti-diabetic phytochemical substances from medicinal plants, World J Diabetes, 2016, Dec 15; 7(20): 605-614 PMID: 28031778

Biological Activity

Streptozotocin (Streptozocin, Zanosar, STZ)is used in medical research to produce an animal model for Type 1 diabetes, which directly inhibist the O-GlcNAcase activity of the enzyme NCOAT in vitro.
In vitro (25°C) DMSO 51 mg/mL (192.29 mM)
Water 51 mg/mL (192.29 mM)
Ethanol Insoluble
In vivo Saline 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 37.71 mL 188.54 mL 377.07 mL
0.5 mM 7.54 mL 37.71 mL 75.41 mL
1 mM 3.77 mL 18.85 mL 37.71 mL
5 mM 0.75 mL 3.77 mL 7.54 mL

*The above data is based on the productmolecular weight 265.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10868
Actions Inhibitor
CAS No. 18883-66-4
Formula C8H15N3O7
M. Wt 265.2
Purity >98%
Synonyms Streptozocin, Zanosar, STZ
SMILES CN(C(=O)N[[email protected]@H]1[[email protected]]([[email protected]@H]([[email protected]](O[[email protected]@H]1O)CO)O)O)N=O

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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