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- Yunjing Yan, .et al. Adiponectin deficiency promotes endometrial carcinoma pathogenesis and development via activation of mitogen-activated protein kinase, J Pathol, 2022, Jun;257(2):146-157 PMID: 35072951
- Uchida T, .et al. The Neuroprotective Effect of the Adiponectin Receptor Agonist AdipoRon on Glutamate-Induced Cell Death in Rat Primary Retinal Ganglion Cells, J Ocul Pharmacol Ther, 2019, Aug 28 PMID: 31460821
Biological Activity
AdipoRon is a novel small-molecule AdipoR agonist; binds to both AdipoR1(Kd= 1.8 uM) and AdipoR2(Kd=3.1 uM). IC50 value: 1.8/3.1 uM(AdipoR1/2, Kd)
Targets
| AdipoR1 | AdipoR2 | |||
| 1.8 μM(Kd) | 3.1 μM(Kd) |
| In vitro | DMSO | 77 mg/mL (179.69 mM) | |
| Water | Insoluble | ||
| Ethanol | 45 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.34 mL | 116.68 mL | 233.36 mL |
| 0.5 mM | 4.67 mL | 23.34 mL | 46.67 mL |
| 1 mM | 2.33 mL | 11.67 mL | 23.34 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.67 mL |
*The above data is based on the productmolecular weight 428.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A13768 |
|---|---|
| Actions | Agonist |
| CAS No. | 924416-43-3 |
| Formula | C27H28N2O3 |
| M. Wt | 428.52 |
| Purity | >98% |
| SMILES | C1CN(CCC1NC(=O)COC2=CC=C(C=C2)C(=O)C3=CC=CC=C3)CC4=CC=CC=C4 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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