Catalog No.
Product Name
Application
Product Information
Citations
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Proapoptotic Peptide
d-KLA Peptide is a synthetic pro-apoptotic peptide that specifically targets mitochondria to induce apoptosis by permeabilizing the mitochondrial membrane. This compound activates essential biochemical pathways associated with apoptosis, including the activation of caspase family proteins and poly ADP ribose polymerase (PARP). d-KLA Peptide is valuable for research applications focused on cancer therapeutics, particularly in enhancing anti-tumor effects through gene or small molecule delivery. -
Negative Control Peptide
PTD (Antennapedia leader peptide) serves as a negative control for the TRAF6 inhibitor peptide DRQIKIWFQNRRMKWKK-RKIPTEDEY. By demonstrating a lack of inhibitory activity, PTD provides a reference point for experimental comparisons in studies involving TRAF6 modulation. Its application is crucial in validating the specificity and efficacy of TRAF6-targeted interventions in various biological research contexts. -
VGF Derived Peptide
LQEQ-19 (mouse, rat) is a VGF-derived peptide that activates the PI3K/Akt and MEK/ERK signaling pathways, stimulating the phosphorylation of Akt and ERK1/2. It exhibits neuroprotective effects, making it a valuable tool for investigating various neurological conditions. LQEQ-19 is widely used in research focused on neural regeneration and neurodegenerative diseases. -
Akt/SKG Substrate
Akt/SKG Substrate Peptide is a synthetic peptide specifically designed as a substrate for Akt/PKB. This peptide is selectively phosphorylated by Akt/PKB and does not undergo phosphorylation by p70S6K or MAPK1, making it an ideal tool for studying the Akt signaling pathway. Its specificity is valuable in research applications focused on cancer, metabolism, and neurological disorders associated with Akt dysregulation. -
Substrate Mimetic Peptide
GSK3β-peptide is a substrate mimetic peptide that targets glycogen synthase kinase 3-β (GSK3-β) by binding to its active site and simulating substrate behavior. This peptide serves as a crucial tool in the development of substrate mimetic inhibitors of Akt, offering potential applications in anticancer drug discovery and research. Its ability to engage with GSK3-β positions it as a valuable reagent for probing signaling pathways involved in cell proliferation and survival. -
Amino Acid Polypeptide Hormone Analogue
Sincalide ammonium is an amino acid polypeptide hormone analogue of cholecystokinin (CCK) that primarily targets gallbladder function. It is utilized in clinical settings for its ability to promote gallbladder contraction, thus facilitating the diagnosis of gallbladder and pancreatic disorders. By increasing bile secretion and causing the contraction of the gallbladder while relaxing the sphincter of Oddi, Sincalide ammonium aids in the efficient drainage of bile into the duodenum, making it a valuable tool in postevacuation cholecystography. -
Antimicrobial Peptide
Cathelicidin-PY is an antimicrobial peptide that targets and inhibits the TLR4 inflammatory response pathways activated by lipopolysaccharide (LPS). This peptide demonstrates significant antimicrobial and anti-inflammatory properties while exhibiting low cytotoxicity in RAW 264.7 cells. Cathelicidin-PY is suitable for research focused on antimicrobial and anti-inflammatory mechanisms. -
B-cell Maturation Antigen Peptide
BCMA72-80 is a HLA-A2-specific peptide derived from the B-cell maturation antigen (BCMA) that exhibits strong binding affinity to HLA-A2. This peptide is primarily utilized in research focused on multiple myeloma and other tumors expressing BCMA. Its application is significant in studying immune responses and developing immunotherapeutic approaches targeting BCMA in oncology. -
Restricted Peptide Antigen
Eps8 peptide 327 is an HLA-A*2402-restricted peptide antigen derived from the Eps8 protein. It exhibits potent antitumor activity through significant cytotoxicity, effectively inhibiting cancer cell proliferation and inducing apoptosis. Eps8 peptide 327 disrupts the EGFR signaling pathway by modulating downstream signals, including IL-2, TNF-α, and IFN-γ, while also interfering with the Eps8/EGFR interaction. Its efficacy has been demonstrated in HT-29 xenograft mouse models, where it significantly inhibits tumor growth. -
Anti-aging Peptide
Acetyl tetrapeptide-2 is an anti-aging peptide that enhances skin rejuvenation by stimulating structural components such as collagen and elastin. This bioactive compound has been shown to reduce the loss of thymic factors, thereby promoting improved cellular stiffness in human keratinocytes (HaCaT cells). Its applications extend to various skin care formulations aimed at combating signs of aging and improving skin resilience. -
CD206 Targeting Peptide
RP-832c is a synthetic analogue of host defense peptides that selectively targets the mannose receptor CD206 on M2 polarized macrophages (Kd = 3.5 μM). Binding of RP-832c to CD206 induces significant conformational changes, activating signaling pathways that promote apoptosis and repolarization of M2 macrophages to an M1 phenotype. The treatment with RP-832c effectively reduces CD206 gene expression while transiently increasing TNF-α levels, a hallmark of M1 macrophages. This reagent is valuable for research on T-cell lymphoma (CTCL) and idiopathic pulmonary fibrosis (IPF). -
Human Neutrophil Peptide
Defensin HNP-1 human is an antimicrobial peptide that primarily targets and modulates the immune response in human neutrophils. It exhibits significant antibacterial activity through the inhibition of DNA, RNA, and protein synthesis, thereby disrupting essential metabolic pathways. Additionally, Defensin HNP-1 demonstrates direct inactivation of various viruses, including HIV, HSV-1, HSV-2, CMV, and influenza. It also possesses antileishmanial properties and plays a role in endothelial cell dysfunction associated with the early stages of atherosclerosis, making it a valuable tool for research in immunology and infectious diseases. -
Bioactive Peptide
WP9QY is a bioactive peptide designed as a TNF-α antagonist. This cyclic peptide effectively mimics the essential recognition loop of tumor necrosis factor on TNF receptor I, thereby inhibiting TNF-receptor interactions. WP9QY serves as a valuable template for developing small molecular inhibitors aimed at mitigating inflammatory bone destruction and systemic bone loss associated with rheumatoid arthritis. -
Cyclic Tetrapeptide
Apicidin C is a cyclic tetrapeptide that primarily targets histone deacetylases (HDACs). It exhibits potent antiprotozoal and antimalarial activity against Eimeria tenella, with an IC50 of 6 nM. This compound is valuable for research into malaria infections and provides insights into HDAC inhibition mechanisms in protozoan parasites. -
Anti-inflammatory Peptide
SAP15 is a synthetic anti-inflammatory peptide derived from human beta-defensin 3, comprising 15 amino acids. This peptide effectively penetrates cells to downregulate intracellular inflammation by inhibiting the phosphorylation of HDAC5, which in turn reduces the phosphorylation of NF-κB p65. In LPS-induced macrophages, SAP15 demonstrates significant anti-inflammatory activity, while also enhancing the expression of aggrecan and type II collagen, and decreasing osteocalcin levels in LPS-induced chondrocytes. SAP15 serves as a valuable tool in the exploration of inflammation regulation and the development of anti-inflammatory therapies for biomaterials. -
SETD8 Inhibitor
[Nle20] H4 peptide (16−23) is a potent inhibitor of the histone methyltransferase SETD8, exhibiting a Kd of 0.14 μM. This peptide competes with histone H4 for binding to the substrate site of SETD8, effectively blocking its methylation activity. As a result, [Nle20] H4 peptide (16−23) serves as a valuable tool in cancer research, offering potential applications in the development of therapeutic strategies targeting epigenetic modulation. -
Antimicrobial Peptide
Dermaseptin-S3 is an antimicrobial peptide that targets and disrupts the membranes of filamentous fungi. It exhibits significant antifungal activity, making it a valuable tool for research in fungal infections and antimicrobial peptide studies. Its mechanism of action entails perturbation of the fungal cell membrane, leading to cell lysis and death, thereby aiding in the exploration of novel antifungal therapies. -
Antimicrobial Peptide
Dermaseptin-S2 is an antimicrobial peptide derived from frog skin, exhibiting potent activity against filamentous fungi. It disrupts cellular membranes, leading to fungal cell death. This peptide is applicable in research related to antifungal mechanisms and the development of novel antimicrobial agents. -
Antimicrobial Peptide
Dermaseptin-S4 is an antimicrobial peptide that targets and inhibits the growth of filamentous fungi. It exhibits potent antifungal activity, making it a valuable reagent for research in antifungal therapy and the study of innate immune mechanisms. This compound can be utilized in the exploration of new therapeutic strategies against fungal infections. -
Antifungal Peptide
LL-25 is an antifungal peptide that exhibits potent candidacidal activity, making it particularly useful in research focused on fungal infections. This compound is a fragment of LL-37, lacking its immunomodulatory effects, which allows for a more targeted investigation of its antifungal properties. LL-25 is applicable in studies exploring therapeutic strategies against fungal pathogens, providing insights into the development of novel antifungal agents. -
Cyclic Peptides
Aselacin C is a cyclic peptide derived from the fungus Acremonium spp. This compound exhibits potent biological activity, serving as an important tool for studying antimicrobial properties and potential applications in drug discovery. Aselacin C provides researchers with valuable insights into peptide synthesis and structure-activity relationships within cyclic peptides, making it relevant for various research applications in the fields of microbiology and pharmacology. -
Antimicrobial Peptide
Dermaseptin-S5 is an antimicrobial peptide that targets and disrupts the membranes of filamentous fungi. This compound exhibits strong antifungal activity, making it a valuable tool in studies focused on fungal infections and resistance mechanisms. It is particularly useful for research in pharmacology, microbiology, and therapeutic applications involving antifungal agents. -
Antibiotic Peptide
CRAMP-18 (mouse) is an antibiotic peptide that exhibits selective antimicrobial activity without hemolytic properties. It demonstrates effective inhibitory action against Gram-negative bacteria, including Salmonella typhimurium and Pseudomonas aeruginosa. This peptide serves as a valuable tool for research applications in antifungal, antibacterial, and antitumor studies. -
Antimicrobial Peptide
Temporin-SHa is an antimicrobial peptide that exhibits broad-spectrum antibacterial activity, effectively targeting both Gram-positive and Gram-negative bacteria, including drug-resistant strains. With a minimum inhibitory concentration (MIC) of 6.25 μM against Listeria ivanovii and 10 μM against Escherichia coli, it is also active against fungal pathogens such as Candida albicans (MIC = 25 μM) and Saccharomyces cerevisiae (MIC = 12 μM). Furthermore, Temporin-SHa demonstrates efficacy against protozoan parasites, including Leishmania infantum and Trypanosoma cruzi, and exhibits antiviral activity against HSV-1, alongside anti-cancer properties that include cytotoxicity against breast cancer (MCF-7) and lung cancer (H460) cell lines. -
Antimicrobial Peptide
NK-2, an antimicrobial peptide derived from NK-lysin, primarily targets microbial membranes. This potent agent demonstrates significant antimicrobial activity against various pathogens, including Trypanosoma cruzi, Candida albicans, as well as both gram-positive and gram-negative bacteria. NK-2 has been shown to effectively eliminate trypanosomes within the human glioblastoma cell line 86HG39 while preserving the integrity of host cells, making it a valuable tool for research into antimicrobial mechanisms and therapeutic applications. -
Antimicrobial Peptide
Pelteobagrin is an antimicrobial peptide known for its broad-spectrum activity against both Gram-positive and Gram-negative bacteria, as well as fungi, with a minimum inhibitory concentration (MIC) ranging from 2 to 16 μg/mL. Its mechanism of action involves non-competitive disruption of cell wall and cytoplasmic membrane integrity, leading to bactericidal effects. Pelteobagrin holds significant potential for research applications in the study and treatment of infectious diseases. -
Antimicrobial Peptide
EP2 is an antimicrobial peptide that exhibits potent antibacterial and antifungal activities. It effectively inhibits the growth of E. gallinarum, P. pyocyanea, A. baumanii, and K. terrigena, with a minimum inhibitory concentration (MIC) of 11.4 μg/mL. This compound is valuable for research applications focusing on microbial resistance and the development of new antimicrobial agents. -
Cyclic Tetrapeptide
Hirsutide is a cyclic tetrapeptide known for its ability to inhibit chitin synthase, an essential enzyme in fungal cell wall biosynthesis. This compound demonstrates potent antifungal activity against a range of pathogenic fungi, making it a valuable tool for research in mycology and antifungal drug development. Its unique mechanism of action positions Hirsutide as a candidate for studying fungal resistance mechanisms and exploring new therapeutic strategies in treating fungal infections. -
Antimicrobial Peptide
Lasioglossin-III is an antimicrobial peptide derived from the venom of wild bees, primarily targeting bacterial and fungal pathogens. It exhibits potent antibacterial activity against both Gram-positive and Gram-negative bacteria, alongside notable antifungal and antitumor properties. Lasioglossin-III demonstrates cytotoxic effects on various cancer cell lines, including HeLa S3, CRC SW 480, and CCRF-CEM T, with IC50 values of 4, 18, and 5 μM, respectively. This peptide holds promise for research applications in the fields of microbiology, oncology, and drug development. -
Defensin-like Antifungal Peptide
Gymnin is a defensin-like antifungal peptide that exhibits notable antifungal activity against both phytopathogenic and mycotoxigenic fungi. Additionally, Gymnin inhibits HIV-1 reverse transcriptase with an IC50 of 200 μM and suppresses tumor cell proliferation, although it demonstrates only weak mitogenic activity in murine splenocytes. This compound is suitable for research applications related to plant disease treatment and the exploration of antifungal mechanisms. -
Antimicrobial Peptide
Bactenecin is a potent antimicrobial peptide that exhibits activity primarily through its ability to increase membrane permeability in target microorganisms. This 12-amino acid looped peptide, derived from bovine neutrophils, effectively inhibits the growth of a range of bacteria and yeast, including the fungus Trichophyton rubrum. Bactenecin is particularly relevant for research applications focused on bacterial pathogenesis and biofilm formation, as it has been shown to impede the growth and biofilm development of Burkholderia pseudomallei. -
Plant Peptide
Cn-AMP1 is a disulfide-free plant peptide derived from green coconut water, targeting various pathogenic organisms. It exhibits antimicrobial activity against multiple pathogenic bacteria and fungal strains, as well as antitumor effects on cancer cells. Additionally, Cn-AMP1 has been shown to up-regulate inflammatory cytokine secretion in monocytes, making it a valuable reagent for research focused on bacterial infections and cancer therapies. -
Acylpeptide Antibiotic
Cepafungin III is an acylpeptide antibiotic derived from the culture broth of Pseudomonas species. This compound demonstrates significant inhibitory activity against yeast and fungi, as well as exhibiting antitumor properties against P388 leukemia in murine models, particularly when utilized in conjunction with Cepafungin I and II. Its multifaceted biological activity makes Cepafungin III a valuable reagent for research in antifungal and anticancer studies. -
Antifungal Peptide
Coccinin is an antifungal peptide that exerts its bioactivity by inhibiting HIV-1 reverse transcriptase. Isolated from the seeds of large scarlet runner beans, Coccinin demonstrates significant antifungal activity against a range of pathogens, including M. arachidicola, F. oxysporum, P. piricola, B. cinerea, C. comatus, and R. solani, with IC50 values of 75, 81, 89, 109, 122, and 134 μM, respectively. This compound is valuable for research in antifungal therapeutics and HIV-related studies. -
Antifungal Peptide
KK14(R) is an analog of the synthetic antifungal peptide KK14, demonstrating potent antifungal activity against Fusarium culmorum, Penicillium expansum, and Aspergillus niger, with minimum inhibitory concentrations (MICs) of 6.25 μg/mL, 12.5 μg/mL, and 12.5 μg/mL, respectively. This compound also exhibits stability under various heat and pH conditions. Additionally, KK14(R) shows cytotoxic effects on Caco-2 and RAW264.7 cell lines, making it a valuable tool for research in fungal infections and cytotoxicity studies. -
Cyclocarboxyphenate Peptide Analogues
Iso-isariin B is a cyclocarboxyphenate analogue that primarily targets antifungal pathways. This compound exhibits biological activity against a variety of fungi, making it a valuable tool for antifungal research studies. Iso-isariin B can aid in the investigation of mechanisms of antifungal action and the development of therapeutic strategies. -
Antimicrobial Peptide
Balteatide is an antimicrobial peptide derived from the skin secretion of Phyllomedusa baltea, targeting various microbial pathogens. This compound demonstrates significant inhibitory activity against gram-positive Staphylococcus aureus (MIC=435 μM), gram-negative Escherichia coli (MIC=109 μM), and Candida albicans (MIC=27 μM). Notably, Balteatide exhibits no hemolytic activity at concentrations up to 512 mg/L, making it a promising candidate for research in antimicrobial applications. -
Antibiotic/Antimicrobial Peptide
Aurein 2.5 is an antibiotic antimicrobial peptide that exhibits potent antibacterial and antifungal activity. It targets microbial membranes, disrupting their integrity and leading to cell death. This compound is valuable for research applications focused on exploring novel antimicrobial therapies and understanding peptide-microbe interactions. -
Antimicrobial peptide
ToAP2 is a potent antimicrobial peptide that targets fungal cell membranes. It enhances membrane permeability in Candida albicans, leading to significant alterations in fungal cell morphology. This compound is useful in research focused on fungal pathogenesis, antimicrobial drug development, and the mechanisms of peptide-based antimicrobial activity. -
Anti-fungal Peptide
Histatin-8 is an anti-fungal peptide derived from the central sequence of Histatin-3, known for its hemagglutination-inhibiting properties. This peptide exhibits potent antimicrobial activity against various yeast strains, making it an important tool for studying oral thrush and related fungal infections. Its unique mechanism of action and biological significance position Histatin-8 as a valuable reagent in antifungal research applications. -
Antimicrobial Peptide
SP-B peptide is an antimicrobial peptide targeting various fungal pathogens. It demonstrates significant antifungal activity against strains of Cryptococcus neoformans, Candida albicans, and Aspergillus fumigatus. This peptide is useful for research applications focusing on antifungal mechanisms and the development of novel therapeutic strategies against fungal infections. -
Antibacterial Peptide
Metchnikowin is an antibacterial peptide derived from fruit flies, exhibiting potent antimicrobial properties against both bacteria and fungi. Its activity is regulated through the TOLL and IMD signaling pathways, making it a valuable tool for studying immune responses in various infectious conditions. This peptide is widely utilized in research focused on host defense mechanisms and the development of novel antimicrobial agents. -
Anti-bacterial Peptide
Pseudin-2 is an antimicrobial peptide derived from the skin of the South American paradoxical frog, Pseudis paradoxa. It exhibits potent growth inhibition against Gram-negative bacteria, making it a valuable tool for antibacterial research. Pseudin-2 may be utilized in studies aimed at understanding antimicrobial mechanisms and developing new therapeutic strategies against resistant bacterial strains. -
Antimicrobial Peptide
Xenopsin precursor fragment is an antimicrobial peptide that exhibits significant antibacterial and antifungal activity, demonstrated at concentrations ranging from 10 to 500 μg/mL. Additionally, it shows potent anti-protozoal effects, with a minimum inhibitory concentration (MIC) between 2 and 20 μg/mL. This peptide is useful for research applications focused on antimicrobial resistance and the development of novel therapeutic agents against infectious diseases. -
Antimicrobial Peptide
Gageotetrin A is an antimicrobial peptide that targets microbial cells with its potent antifungal properties. Derived from the marine bacterium Bacillus subtilis, Gageotetrin A effectively inhibits fungal growth while demonstrating low toxicity towards various human cancer cell lines. This makes it a valuable candidate for research applications in antimicrobial and anticancer studies. -
Antimicrobial Peptide
BTL peptide is an antimicrobial peptide with potent antifungal properties. It demonstrates effectiveness against various fungal pathogens, including Bipolaris maydis, Alternaria brassicae, Aspergillus niger, and Corynespora personata. This peptide is a valuable tool for research applications aimed at understanding fungal resistance mechanisms and developing novel antifungal therapies. -
Antimicrobial Peptide
Jelleine-I is an antimicrobial peptide known for its broad-spectrum activity against various microorganisms, including yeast, fungi, and both Gram-positive and Gram-negative bacteria. Isolated from royal jelly produced by honeybees, Jelleine-I plays a crucial role in the insect immune response. This peptide is of interest in research related to antimicrobial therapies and the development of novel biocontrol agents in agriculture and medicine. -
Antimicrobial Peptide
Polybia-MP1 is an antimicrobial peptide that targets cell membranes by selectively interacting with phosphatidylserine (PS) and phosphatidylethanolamine (PE). It exhibits notable antibacterial activity against Pseudomonas aeruginosa, along with antifungal and anticancer properties through the induction of necrosis via pore formation. Polybia-MP1 is suitable for research applications related to bacterial and fungal infections as well as cancer studies. -
Antimicrobial Peptide
Dermaseptin-S1 is an antimicrobial peptide that targets membrane integrity in filamentous fungi. Exhibiting potent antifungal activity, it disrupts the cell membrane of target organisms, leading to cell death. This peptide is valuable for research applications focused on developing antifungal therapies and understanding host-pathogen interactions. -
Antimicrobial Peptide
D-Cateslytin is an antimicrobial peptide that demonstrates significant inhibitory activity against Candida albicans, with a minimum inhibitory concentration (MIC) of 2.9 μM. This compound can rapidly penetrate C. albicans cells while exhibiting no cytotoxic effects on human gingival fibroblasts, and it remains stable in saliva. D-Cateslytin is ideal for research on conditions associated with Candida albicans, including oral candidosis.
