Catalog No.
Product Name
Application
Product Information
Citations
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Antifungal Peptides
Cyclo(L-Phe-trans-4-OH-L-Pro) is a cyclic peptide that exhibits antifungal activity by disrupting the integrity of fungal cell membranes. This compound is valuable in research focused on developing novel antifungal agents and studying the mechanisms of peptide-based antifungal strategies. Its precise mechanism of action makes it a potential candidate for addressing fungal resistance in clinical settings. -
Antimicrobial Peptide
Temporin L is a potent antimicrobial peptide that primarily targets Gram-negative bacteria and yeast strains. It exhibits significant antimicrobial activity, making it suitable for research applications focused on infection control and antimicrobial resistance. Additionally, Temporin L demonstrates antiendotoxin properties, contributing to its role in studies related to inflammatory responses. -
Antimicrobial Peptide
Thanatin is an inducible cationic antimicrobial peptide that targets microbial membranes. It exhibits broad-spectrum antimicrobial activity against both Gram-negative and Gram-positive bacteria, as well as various fungi, with minimum inhibitory concentrations (MICs) ranging from 0.3 to 40 µM. Thanatin functions by competitively displacing divalent cations from the bacterial outer membrane, resulting in membrane disruption and enhanced permeability. This peptide is valuable for research applications in antimicrobial resistance, infection mechanisms, and the development of novel antibacterial agents. -
Antimicrobial Peptide
Magainin 1 is an antimicrobial peptide that targets bacterial membranes. Isolated from the skin of Xenopus laevis, it displays significant antibacterial activity against a broad spectrum of both Gram-negative and Gram-positive bacteria. This peptide serves as a valuable tool for research in antimicrobial mechanisms and can be utilized in studies assessing the efficacy of peptide-based antibiotics. -
Antimicrobial Peptide
Temporin A is an alpha-helical antimicrobial peptide derived from the skin of the European common frog, Rana temporaria. This peptide exhibits broad-spectrum activity against Gram-positive bacteria by disrupting microbial cell membranes, while demonstrating non-toxicity to erythrocytes at effective antimicrobial concentrations. Additionally, Temporin A possesses antifungal properties, notably against Candida albicans, making it a valuable reagent for research in antimicrobial peptide function and potential therapeutic applications. -
Antimicrobial Peptide
Nisin Z is an antimicrobial peptide that primarily targets Gram-positive bacteria and fungi, including Candida albicans. It exhibits notable antimicrobial and anti-inflammatory properties, making it a valuable tool for research into bacterial resistance and fungal infections. Nisin Z is utilized in various applications, including food preservation, therapeutic development, and studies on peptide-based antimicrobial strategies. -
HER2-Derived Antigen Peptide
CH401 peptide is a HER2-derived antigen peptide that functions as a vaccine candidate for anti-breast cancer therapy. It is encapsulated within a lipid bilayer containing the lipid adjuvant α-GalCer, following binding to an artificial viral capsid via a self-assembled β-cyclic peptide. This innovative formulation allows for comprehensive investigations into its self-adjuvant properties and its potential in eliciting robust immune responses against HER2-expressing tumors. -
Tumor-specific Mutation
EGFRvIII peptide (PEPvIII) is a tumor-specific mutation predominantly expressed in glioblastoma multiforme (GBM) and various other neoplasms, significantly contributing to enhanced tumorigenicity. This peptide serves as a valuable target for the development of antitumor immunotherapies, allowing for the potential targeting of cancer cells while sparing normal tissues. Its specific expression profile makes it a crucial tool for research into GBM and other malignancies. -
Peptide
ELAAWCRWGFLLALLPPGIAG is a peptide derived from the rat HER2/neu protein, comprising 21 amino acids (aa 5-25). It has been demonstrated to induce cytotoxic T lymphocyte (CTL) responses in mice with HER2-positive tumors, making it a valuable tool for studying immune responses in cancer therapy. This peptide is particularly relevant for research applications focused on immunotherapy and the modulation of tumor-specific immune responses. -
EGFR-binding peptide
LARLLT is an EGFR-binding peptide that specifically targets the epidermal growth factor receptor (EGFR). This compound exhibits potential in the research of cancers characterized by EGFR overexpression, including lung, ovarian, and colorectal cancers. Its application in studies may facilitate insights into tumor biology and therapeutic interventions in EGFR-driven malignancies. -
HER2-Targeting Peptide
Herceptide is a HER2-targeting peptide that selectively binds to the human epidermal growth factor receptor 2 (HER2). This peptide can be conjugated with the near-infrared fluorescent dye indocyanine green (ICG), facilitating the development of innovative theranostic agents. Its primary applications include targeted imaging and therapy for HER2-positive cancers, enhancing the precision of cancer diagnostics and treatment strategies. -
Hexapeptide
Lys-Arg-Thr-Leu-Arg-Arg (KRTLRR) is a hexapeptide that serves as a substrate for protein kinase C (PKC) derived from the epidermal growth factor receptor (EGFR). This compound is instrumental in studying PKC activity, enabling researchers to elucidate its role in various signaling pathways. Research applications include assessing the enzymatic function of PKC and exploring its implications in cellular processes such as proliferation and differentiation. -
Peptide
pp60v-src Autophosphorylation site is a synthetic peptide that mimics the autophosphorylation site of the pp60v-src protein. This peptide is utilized in biochemical studies to investigate the regulation of protein tyrosine kinases and their signaling pathways. It serves as a valuable tool in research focusing on cancer biology, cell signaling, and the mechanisms of oncogenesis. -
HER2 Targeting Peptide
HER2-targeted peptide H6F is designed to selectively bind to the HER2 receptor, making it a valuable tool for targeting breast cancer cells. Its amino acid sequence, YLFFVFER, allows for effective conjugation with the bifunctional chelating agent hydrazinonicotinamide (HYNIC) for radiolabeling with 99mTc. Studies utilizing single-photon emission computed tomography (SPECT) demonstrate that the radiolabeled H6F peptide accumulates specifically in HER2-positive MDA-MBA-453 tumor-bearing mouse models. This peptide is applicable for tumor molecular imaging studies, aiding in the evaluation and monitoring of breast cancer. -
HER2/neu Peptide
HER2/neu (654-662) GP2 is a peptide derived from the human epidermal growth factor receptor 2 (HER2/neu) that consists of nine amino acids. This specific peptide elicits HLA-A2-restricted cytotoxic T lymphocyte (CTL) responses, making it relevant for research involving immunotherapy and cancer treatment. Its application is particularly significant in the context of various epithelial cancers, facilitating the study of immune responses and potential therapeutic strategies. -
Peptide Toxin
Candidalysin is a cytolytic peptide toxin derived from the pathogenic fungus Candida albicans, primarily targeting epithelial cells. This peptide is known for its ability to activate the EGFR-MAPK signaling pathway, which leads to increased expression of matrix metalloproteinases (MMPs) and calcium influx, as well as modulation of the c-Fos transcription factor through p38 MAPK and ERK1/2. Candidalysin plays a critical role in both mucosal and systemic infections by stimulating NLRP3 inflammasome activation, promoting inflammatory responses, neutrophil recruitment, and Th17 immunity. Additionally, it induces lactate dehydrogenase (LDH) release, resulting in membrane damage and cytotoxicity. -
Tumor-binding Peptide
ErbB-2-binding peptide is a tumor-targeting peptide that specifically interacts with the ErbB-2 receptor (HER2). This peptide demonstrates significant potential in cancer research by aiding in the selective identification and targeting of HER2-positive tumors. Its unique binding properties make it a valuable tool for studies focused on tumor biology, therapeutic delivery, and the development of targeted cancer treatments. -
EGFR Targeting Peptide
Cys-GE11 is a cysteine-modified peptide that targets the epidermal growth factor receptor (EGFR). This peptide can be conjugated via its thiol group, enabling the formation of targeted polymeric constructs to improve drug delivery efficacy. Cys-GE11 demonstrates enhanced enrichment of therapeutic agents at tumor sites, particularly in EGFR-overexpressing cells, such as SMMC-7721. Its utilization in research highlights its potential for applications in targeted cancer therapy with minimal toxicity. -
Peptide
Transcriptional Intermediary Factor 2 (TIF2) (740-753) is a peptide derived from the TIF-2 coactivator, encompassing amino acid residues 740-753 of the TIF-2 protein. This 14-amino acid peptide plays a crucial role in the modulation of transcriptional activity by enhancing the interaction between transcription factors and the basal transcriptional machinery. It is commonly utilized in research applications focused on gene expression, transcriptional regulation, and cell signaling pathways. -
Peptide Interacting With hNatD
Histone H4 peptide is a peptide that specifically interacts with hNatD, facilitating important polar interactions within cellular processes. This peptide is valuable for studying post-translational modifications and histone dynamics. It is particularly applicable in lung cancer research, aiding in the understanding of epigenetic regulation and potential therapeutic targets in oncology. -
Antitumor Peptide
Azurin p28 peptide is an antitumor peptide that primarily targets and stabilizes the tumor suppressor protein p53. By forming a complex with p53, it reduces proteasomal degradation, leading to apoptosis or cell cycle arrest in p53-positive tumors. Additionally, Azurin p28 peptide exhibits antiangiogenic properties by inhibiting the phosphorylation of key signaling molecules, including VEGFR-2, FAK, and Akt, thereby impeding tumor growth and vascularization. This peptide is valuable in cancer research focusing on p53-mediated pathways and antiangiogenic strategies. -
Cardiomyocyte Specific Peptide
WLSEAGPVVTVRALRGTGSW is a cardiomyocyte-specific peptide designed to enhance targeted cellular delivery. This peptide facilitates improved uptake by cardiomyocytes, reduces apoptosis within these cells, and promotes enhanced retention of therapeutic agents following intramyocardial injection in vivo. It is a valuable reagent for research applications focusing on cardiac tissue engineering and myocardial protection strategies. -
NLRP3-targeting Renalase Peptide
RP-220 is a renalase peptide that specifically targets the NLRP3 inflammasome. It exhibits significant anti-inflammatory and anti-apoptotic properties, evidenced by its ability to inhibit apoptosis in renal tubular epithelial cells under alkaline stress through activation of the MAPK signaling pathway. Additionally, RP-220 reduces NLRP3 expression, limits macrophage infiltration, and mitigates kidney tissue damage in models of acute kidney injury (AKI). This reagent is particularly relevant for research into systemic lupus erythematosus (SLE) and its associated complication, lupus nephritis (LN). -
Peptide
Corisin is a peptide derived from Staphylococcus nepalensis, known for its ability to induce apoptosis in targeted cells. This compound plays a significant role in studies related to pulmonary fibrosis, demonstrating potential implications in understanding disease mechanisms and therapeutic approaches. Its unique biological activity positions Corisin as a valuable tool for researchers investigating apoptosis and fibrotic processes. -
Hair-generating Peptide
Octapeptide-2 is a biomimetic peptide designed to mimic the effects of thymosin-β4, targeting hair follicle regeneration. This compound exhibits significant biological activities, including promoting hair growth, reducing cell apoptosis, and enhancing keratinocyte proliferation. Octapeptide-2 is particularly relevant for research focused on hair loss conditions, such as alopecia areata, and is instrumental in exploring potential therapeutic strategies for follicular disorders. -
Toxin Depsipeptide
Cereulide is a toxin depsipeptide produced by Bacillus cereus, primarily targeting mitochondrial function. It induces apoptosis in various cell types, leading to mitochondrial dysfunction and affecting multiple organ systems, including the liver, pancreas, brain, and intestines, as well as the immune and nervous systems. This compound is valuable for research into cellular apoptosis mechanisms and the pathological effects of bacterial toxins on human health. -
Anti-tumor Peptide
ARF(26–44), cell-permeable is a cell-penetrating peptide derived from the p14ARF tumor suppressor protein and functions as an inhibitor of FoxM1. This peptide exhibits marked anti-tumor activity, demonstrating the ability to increase apoptosis and decrease proliferation and angiogenesis in mouse models of hepatocellular carcinoma (HCC). ARF(26–44), cell-permeable serves as a valuable tool for research focusing on tumor therapy and the molecular mechanisms underlying cancer progression. -
Amino Acid Neuropeptide
Argipressin diacetate, an amino acid neuropeptide, primarily targets G-protein coupled receptors, including Avpr1a (V1a), Avpr1b (V1b), and Avpr2 (V2). It plays a crucial role in regulating fluid balance, osmolality, and cardiovascular function. This compound is also influential in centrally mediated metabolic processes, making it valuable for research in neuroendocrine regulation and metabolic disorders. -
Bioactive Peptide
KLA peptide is a bioactive peptide that targets mitochondrial membranes to induce apoptosis through membrane disruption. Its cationic amphipathic structure facilitates cellular uptake and interaction with mitochondrial components. KLA peptide is valuable for research applications in cancer, inflammation, and neurological diseases, allowing for the exploration of apoptotic pathways and therapeutic interventions. -
Anti-cancerous Peptide
Cr-ACP1 is an anti-cancerous peptide that selectively binds to DNA, inducing cell cycle arrest in the G0-G1 phase. This mechanism triggers apoptosis, making Cr-ACP1 a potent agent against various cancer types. Notably, it demonstrates significant anticancer effects in colon cancer and epidermoid carcinoma research applications. -
Antifungal Peptide
Periplanetasin-2 is an antifungal peptide that exerts its effects primarily through the induction of oxidative stress by generating reactive oxygen species (ROS) and promoting lipid peroxidation. In addition to its antifungal activity, Periplanetasin-2 can also trigger apoptosis in target cells. This compound is valuable for research applications aimed at understanding fungal pathogenesis and evaluating potential therapeutic strategies against fungal infections. -
Fas Mimetic Peptide/Fas/FasL Antagonist
Kp7-6 is a Fas mimetic peptide that acts as a Fas/FasL antagonist. It selectively binds to the Fas receptor and Fas ligand, disrupting receptor complexes and inhibiting downstream apoptotic signaling pathways. This includes the suppression of caspase-8 and caspase-3 activation, thereby preventing β-cell apoptosis and reducing FasL-induced lymphoid cytotoxicity. In preclinical models, Kp7-6 has demonstrated efficacy in reducing tumor volume and enhancing T cell infiltration in pancreatic neuroendocrine tumors, and it has also been shown to protect against concanavalin A-induced liver injury. The compound is relevant for research in type 2 diabetes, inflammation, and cancer biology. -
N-Formyl Peptide Receptor Agonist
WKYMVm is a selective agonist of the N-formyl peptide receptor, specifically FPR2. It exhibits significant anti-inflammatory properties, demonstrating potential to reduce lung and spinal cord injuries. Additionally, WKYMVm influences metabolic pathways by regulating lipid metabolism and leptin signaling, contributing to obesity management. Its role extends to immune cell regulation, where it promotes chemotactic migration and inhibits phagocyte apoptosis. The compound may have variable effects in tumor biology, with potential to either support or hinder tumor progression based on the tumor type. -
Bioactive Peptide
MOTS-c (human) is a bioactive peptide derived from mitochondria that modulates the AMPK/PGC-1α pathway, thereby enhancing insulin sensitivity. This peptide inhibits the folate cycle and de novo purine synthesis, elevating AICAR levels to activate AMPK, which regulates the Nrf2/Keap1 antioxidant pathway and suppresses the NF-κB inflammatory pathway. MOTS-c promotes mitochondrial biogenesis and energy metabolism, resulting in improvements in glucose and lipid metabolism, anti-oxidative stress, and neuroprotection. It is applicable in research studying type 2 diabetes, traumatic brain injury, inflammatory diseases, and age-related metabolic disorders. -
Antimicrobial Peptide
Protegrin-1 is an antimicrobial peptide that exhibits potent antibacterial activity by activating ERK, COX2, and NFκB pathways, while inhibiting apoptosis and nitric oxide production. It demonstrates significant bactericidal effects against various pathogens, including Staphylococcus aureus, Enterococcus faecium, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae, with minimal inhibitory concentrations ranging from 10 to 20 µM. Additionally, Protegrin-1 shows antiviral activity against the dengue virus NS2B-NS3 and possesses anti-inflammatory properties, making it a valuable tool in the research of inflammatory diseases and infections. -
Antiangiogenic TSP Peptide
ABT-510 acetate is an anti-angiogenic Thrombospondin-1 analogue that targets angiogenesis and promotes apoptosis in ovarian tumors. Its efficacy has been demonstrated in murine models, significantly inhibiting tumor growth in epithelial ovarian cancer and reducing angiogenesis and inflammation in inflammatory bowel disease. This compound is a valuable tool for research focused on cancer biology and inflammatory conditions. -
Mitochondrial Derived Peptide
SHLP2 (Small humanin-like peptide 2) is a mitochondrial-derived peptide that primarily targets mitochondrial function. It regulates apoptosis and inhibits cell death through its interaction with mitochondrial complex 1. SHLP2 enhances mitochondrial metabolism by improving respiration and biogenesis, while reducing reactive oxygen species (ROS) and diminishing mtDNA oxidation. Additionally, SHLP2 plays a role in energy homeostasis by activating hypothalamic neurons. This peptide is utilized in research focusing on mitochondrial dysfunction and age-related diseases such as age-related macular degeneration and Parkinson's disease. -
MMP2-Cleavable Polypeptide
GPLGIAGQ is an MMP2-cleavable polypeptide utilized as a stimulus-sensitive linker in liposomal and micellar nanocarriers for targeted tumor delivery. This compound enables the synthesis of innovative MMP2-targeted photosensitizers, enhancing the efficacy of photodynamic therapy (PDT) applications. Its selective cleavage by MMP2 facilitates precise drug release in the tumor microenvironment, making it a valuable tool in cancer research and therapy. -
Slimming Peptide
Tripeptide-41 (CG-Lipoxyn) is a signaling peptide that activates the NF-kB pathway. By inhibiting the expression of C/EBP and increasing cAMP levels, this tripeptide plays a critical role in stimulating lipolysis, promoting the hydrolysis of lipids into triglycerides. Tripeptide-41 is particularly useful in cosmetic formulations aimed at reducing fat accumulation and enhancing body contouring. -
Peptide
BPC 157 acetate is a bioactive peptide with a primary mechanism of promoting wound healing and tissue repair. It demonstrates significant biological activities, including enhancing tendon healing, providing neuroprotection, and offering gastrointestinal protection. This peptide is valuable in research applications related to tendon injuries, burn recovery, gastric ulcers, and various neurological disorders. -
Bioactive Peptide
Jak3tide is a biologically active peptide that serves as a substrate for Janus kinase 3 (JAK3). It contains a phosphorylation site at Tyr7, making it suitable for kinase assay applications. This peptide can be utilized in various research settings to study JAK3-mediated signaling pathways and its role in cellular activities. -
Peptide
Tyrosine Protein Kinase JAK 2 (Phospho-Tyr8, 9) is a peptide derived from amino acids 475 to 491 of the mouse JAK2 protein. This peptide serves as a substrate for the examination of JAK2 phosphorylation at tyrosine residues 8 and 9, providing insights into its regulatory mechanisms. It is valuable for studying JAK2-related signaling pathways and their implications in various cellular processes and diseases, including hematopoiesis and immune response. -
FGFR Activator
FGL peptide is a fibroblast growth factor receptor (FGFR) activator that effectively penetrates the blood-brain barrier. It initiates NCAM-FGFR and FGFR1 signaling pathways, which modulate the expression of genes involved in apoptosis, signal transduction, and metabolic regulation. FGL peptide is primarily utilized in research focused on traumatic brain injury, offering insights into its underlying molecular mechanisms and potential therapeutic targets. -
Bioactive Peptide
Abl protein tyrosine kinase substrate is a bioactive peptide designed to interact specifically with Abl kinase, a crucial component of the gag-Abl fusion protein derived from the Abelson murine leukemia virus. This substrate facilitates the study of Abl kinase activity through various biochemical assays, including Western blotting and kinase assays. Its precise reactivity enables researchers to investigate kinase signaling pathways and their roles in cellular processes, particularly in cancer research. -
Peptide Connecting The A And B Chains Of Proinsulin
Proinsulin C-peptide (human) is a 31-amino acid peptide that facilitates the proper folding of proinsulin by connecting its A and B chains. This peptide has been shown to inhibit high glucose-induced upregulation of PDGF-β receptor protein expression and the phosphorylation of p42/p44 MAP kinase. Additionally, Proinsulin C-peptide enhances the deformability of erythrocytes in type 1 diabetes and suppresses the proliferation of rat aortic smooth muscle cells under hyperglycemic conditions, with potential implications for vascular complications in diabetes research. -
Insulinotropic Polypeptide
Acetyl Gastric Inhibitory Peptide (human) is a fatty acid-derived analog of glucose-dependent insulinotropic polypeptide that enhances antihyperglycemic and insulinotropic effects. This compound exhibits significant activity in promoting insulin secretion in response to glucose, making it a valuable tool for investigating diabetes, insulin resistance, and obesity. Its improved properties allow for detailed research into metabolic disorders and the mechanisms underlying glycemic control. -
Insulinotropic Polypeptide
Gastric Inhibitory Polypeptide (1-30), porcine is an insulinotropic polypeptide that enhances the secretion of insulin and somatostatin. This truncated form, missing the C-terminal 12 amino acids of the natural GIP, maintains key biological activity, making it valuable for research in glucose metabolism and endocrine function. It is particularly useful in studies examining the role of incretin hormones in insulin regulation. -
Insulinotropic Polypeptide
GIP (1-30) amide, porcine is an agonist of the glucose-dependent insulinotropic polypeptide (GIP) receptor, exhibiting high affinity comparable to native GIP (1-42). This peptide demonstrates significant insulin-stimulating activity while also serving as a weak inhibitor of gastric acid secretion. It is valuable in research focused on metabolic disorders, insulin signaling, and gastrointestinal physiology. -
Peptide
[pTyr1146][pTyr1150][pTyr1151]Insulin Receptor (1142-1153) is a phosphorylated peptide that targets the insulin receptor, serving as a substrate for insulin receptor tyrosine kinase activity. This reagent is essential for studying insulin signaling pathways and receptor activation. It provides valuable insights into the mechanisms of metabolism, growth, and differentiation mediated by insulin action in various biological systems. -
Insulinogen Fraction
C-Peptide 2 (rat) is a 31-amino-acid peptide derived from proinsulin that plays a crucial role in insulin processing. This compound is known for its ability to inhibit glucose-induced insulin secretion, making it valuable for studies related to insulin regulation and diabetes research. C-Peptide 2 (rat) can serve as a useful tool in the investigation of insulin dynamics and metabolic disorders.
