[Nle20] H4 peptide (16−23) is a potent inhibitor of the histone methyltransferase SETD8, exhibiting a Kd of 0.14 μM. This peptide competes with histone H4 for binding to the substrate site of SETD8, effectively blocking its methylation activity. As a result, [Nle20] H4 peptide (16−23) serves as a valuable tool in cancer research, offering potential applications in the development of therapeutic strategies targeting epigenetic modulation.
[Nle20] H4 peptide (16−23) is a potent inhibitor of the histone methyltransferase SETD8, exhibiting a Kd of 0.14 μM. This peptide competes with histone H4 for binding to the substrate site of SETD8, effectively blocking its methylation activity. As a result, [Nle20] H4 peptide (16−23) serves as a valuable tool in cancer research, offering potential applications in the development of therapeutic strategies targeting epigenetic modulation.
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![[Nle20] H4 peptide (16−23) 2042178-19-6 SETD8 Inhibitor](https://www.adooq.com/media/catalog/product/cache/9222bce87e7def4079ba2ab8616be292/a/2/a26673-nle20-h4-peptide-16-23.gif)
