Catalog No.
Product Name
Application
Product Information
Citations
- Autoinducing Peptide I is a cyclic octapeptide secreted by Staphylococcus aureus and can be used in vaccine research.
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Fluorescent Dye
Mca-SEVNLDAEFK(Dnp)-NH2 contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence, such as can be used to measure the activity of BACE-1. -
PAR-1 agonist
iso-TRAP-6 (iso-SFLLRN) is a PAR-1 agonist that can activate platelets. iso-TRAP-6 is an analog of TRAP-6 that refers to the use of isoserine instead of serine as first amino acid. - Cbz-Asn-Gly-OH is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
- γ-Glutamylhistidine is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development.
- β-Amyloid peptide(16-20) is a amino acid sequences (KLVFF) of Amyloid-β (Abeta). β-Amyloid peptide(16-20) is an effective inhibitor of Abeta fibril formation, with RG-/-GR-NH2 residues added at N- and C-terminal ends to aid solubility).
- Hexapeptide-12isa bioactive peptide with anti-aging effect and has been reported used as a cosmetic ingredient.
- Histatin-3 TFA, a 32 amino acid peptide, possesses powerful antimicrobial properties. Histatin-3 TFA behaves as a substrate for proprotein convertase 1 (PC1), being cleaved by this endoprotease primarily at a site carboxy terminal to the single Arg25 residue (HRGYR decrease SN). Histatin-3 TFA is a moderately potent, reversible and competitive inhibitor of the furin-mediated cleavage of the pentapeptide pGlu-Arg-Thr-Lys-Arg-MCA fluorogenic substrate, with an estimated inhibition constant Ki of 1.98 μM.
- Insulin receptor (1142-1153), pTyr1150 is a biological active peptide. (Peptide used as insulin receptor tyrosine kinase substrate.)
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GnRH peptide agonist
Triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) peptide agonist that binds to the GnRH receptor. It inhibits the growth of DU145, LNCaP, and PC3 prostate and OVCAR-3 ovarian cancer cells. -
Tripeptide
RGD Trifluoroacetate is a tripeptide that specifically interacts with integrins to promote cell adhesion. This compound is instrumental in studying cellular processes related to adhesion and migration, making it valuable for research in cancer, tissue engineering, and regenerative medicine. Its ability to elicit specific cellular responses makes it a crucial tool for elucidating integrin-mediated pathways. -
Cell-Penetrating Peptide
Cys-Penetratin is a cell-penetrating peptide (CPP) characterized by the sequence CRQIKIWFQNRRMKWKK. This peptide facilitates the translocation of various biomolecules across cellular membranes, enhancing their delivery into living cells. Cys-Penetratin is widely used in research applications focused on drug delivery, gene therapy, and intracellular protein transportation. Its ability to efficiently transport cargo makes it a valuable tool in cellular and molecular biology studies. -
Anti-aging Peptide
Acetyltetrapeptide 11 is a bioactive peptide recognized for its anti-aging properties. It functions by promoting collagen synthesis and enhancing skin elasticity, making it valuable in cosmetic formulations aimed at reducing signs of aging. Its application extends to skincare products where it aids in rejuvenating and revitalizing the skin. -
Neuroactive Peptide
Gly-Pro-Glu is a neuroactive peptide that significantly influences acetylcholine release. As the N-terminal tripeptide of insulin-like growth factor-I, it effectively inhibits glutamate binding to the N-methyl-D-aspartate (NMDA) receptor, exhibiting an IC50 of 14.7 μM. This compound is valuable for research focused on neuroprotection and the modulation of neurophysiological processes. -
NK2/NK3 Receptor Agonist
Eledoisin is a specific agonist of the NK2 and NK3 receptors. This bioactive peptide exhibits significant biological activity in modulating neurokinin pathways, making it valuable in the study of pain and inflammatory responses. Eledoisin is utilized in research applications related to neurobiology and pharmacology, particularly in the exploration of neurokinin receptor signaling and its implications in various physiological processes. -
CD13 Receptor-binding Peptide
NGR peptide is a receptor-binding peptide that targets the aminopeptidase N (APN/CD13). This peptide demonstrates specific binding to CD13, facilitating its use as a key element in imaging applications. By conjugating NGR peptide to imaging agents, it allows for enhanced visualization of tumor sites, making it a valuable tool in cancer research and diagnostics. -
Synthetic Peptide Substrate
Ac-VETD-AMC is a synthetic peptide substrate specifically designed for the enzyme caspase 8. This compound enables the assessment of caspase activity, making it a valuable tool in apoptosis research. Additionally, Ac-VETD-AMC has the potential to evaluate the functional activity of recombinant phytaspase, contributing to studies in cell signaling and programmed cell death. -
Antimicrobial Peptide
Periplanetasin-4 is an antimicrobial peptide derived from the American cockroach (Periplaneta americana) that targets microbial pathogens. This peptide exhibits significant biological activities, including the reduction of cell rounding and apoptosis, while also inhibiting Clostridium difficile toxin A-induced reactive oxygen species (ROS) production. Periplanetasin-4 enhances mitochondrial calcium levels and mitigates vacuolar dysfunction in Candida albicans, highlighting its potential in antifungal research. Additionally, it demonstrates protective effects against toxin A-induced mucosal damage in mouse models, making it a valuable reagent for studies on colitis and intestinal health. -
Three Amino Acid Peptide
GPR is a three amino acid peptide that targets apoptosis pathways by inhibiting caspase-3/p53 dependent mechanisms. It demonstrates protective effects against amyloid beta (Aβ)-induced neuronal cell death in cultured rat hippocampal neurons. GPR is valuable for research related to Alzheimer's disease and studies focused on neuroprotection and cellular survival. -
T1/ST2 Receptor Ligand
d-T101 peptide is an important ligand for the T1/ST2 receptor, primarily involved in mediating apoptosis through the activation of caspases 3, 8, and 9, along with JNKinase and p38 MAPKinase pathways. This peptide exhibits significant immunostimulatory and anticancer properties by selectively inducing apoptosis in proliferating cancer cells. It enhances the expression of interleukin-2 (IL-2) and interferon-gamma (IFN-γ), as well as promoting the recruitment of natural killer (NK) cells and M1 macrophages to tumor sites. d-T101 peptide is invaluable for research in cancer immunotherapy and the modulation of immune responses. -
Smac-N7 Peptide
Smac-N7 peptide is derived from the N-terminal region of the mitochondrial protein Smac, a known activator of caspases. This peptide primarily targets and enhances apoptotic signaling pathways by promoting caspase activation, thereby facilitating programmed cell death. Due to its inability to penetrate cell membranes, Smac-N7 is useful for studying the mechanisms of apoptosis and can serve as a potent tool in cancer research and therapeutic development focused on apoptotic modulation. -
CD206 Targeting Peptide
RP-182 is a synthetic immunomodulatory peptide that targets the mannose receptor CD206 on tumor-associated macrophages (TAMs), exhibiting a dissociation constant (Kd) of 8 μM. By inducing a conformational change in the CD206 receptor, RP-182 activates NF-κB signaling, promoting TNFα secretion and phagocytosis in CD206high TAMs, ultimately leading to apoptosis via caspase 8 activation. This compound is valuable for research in pancreatic cancer and melanoma, providing insights into therapeutic strategies that enhance anti-tumor immunity. -
Proapoptotic Peptide
d-KLA Peptide is a synthetic pro-apoptotic peptide that specifically targets mitochondria to induce apoptosis by permeabilizing the mitochondrial membrane. This compound activates essential biochemical pathways associated with apoptosis, including the activation of caspase family proteins and poly ADP ribose polymerase (PARP). d-KLA Peptide is valuable for research applications focused on cancer therapeutics, particularly in enhancing anti-tumor effects through gene or small molecule delivery. -
NLRP3-targeting Renalase Peptide
RP-220 is a renalase peptide that specifically targets the NLRP3 inflammasome. It exhibits significant anti-inflammatory and anti-apoptotic properties, evidenced by its ability to inhibit apoptosis in renal tubular epithelial cells under alkaline stress through activation of the MAPK signaling pathway. Additionally, RP-220 reduces NLRP3 expression, limits macrophage infiltration, and mitigates kidney tissue damage in models of acute kidney injury (AKI). This reagent is particularly relevant for research into systemic lupus erythematosus (SLE) and its associated complication, lupus nephritis (LN). -
Peptide
Corisin is a peptide derived from Staphylococcus nepalensis, known for its ability to induce apoptosis in targeted cells. This compound plays a significant role in studies related to pulmonary fibrosis, demonstrating potential implications in understanding disease mechanisms and therapeutic approaches. Its unique biological activity positions Corisin as a valuable tool for researchers investigating apoptosis and fibrotic processes. -
Hair-generating Peptide
Octapeptide-2 is a biomimetic peptide designed to mimic the effects of thymosin-β4, targeting hair follicle regeneration. This compound exhibits significant biological activities, including promoting hair growth, reducing cell apoptosis, and enhancing keratinocyte proliferation. Octapeptide-2 is particularly relevant for research focused on hair loss conditions, such as alopecia areata, and is instrumental in exploring potential therapeutic strategies for follicular disorders. -
Toxin Depsipeptide
Cereulide is a toxin depsipeptide produced by Bacillus cereus, primarily targeting mitochondrial function. It induces apoptosis in various cell types, leading to mitochondrial dysfunction and affecting multiple organ systems, including the liver, pancreas, brain, and intestines, as well as the immune and nervous systems. This compound is valuable for research into cellular apoptosis mechanisms and the pathological effects of bacterial toxins on human health. -
Anti-tumor Peptide
ARF(26–44), cell-permeable is a cell-penetrating peptide derived from the p14ARF tumor suppressor protein and functions as an inhibitor of FoxM1. This peptide exhibits marked anti-tumor activity, demonstrating the ability to increase apoptosis and decrease proliferation and angiogenesis in mouse models of hepatocellular carcinoma (HCC). ARF(26–44), cell-permeable serves as a valuable tool for research focusing on tumor therapy and the molecular mechanisms underlying cancer progression. -
Amino Acid Neuropeptide
Argipressin diacetate, an amino acid neuropeptide, primarily targets G-protein coupled receptors, including Avpr1a (V1a), Avpr1b (V1b), and Avpr2 (V2). It plays a crucial role in regulating fluid balance, osmolality, and cardiovascular function. This compound is also influential in centrally mediated metabolic processes, making it valuable for research in neuroendocrine regulation and metabolic disorders. -
Bioactive Peptide
KLA peptide is a bioactive peptide that targets mitochondrial membranes to induce apoptosis through membrane disruption. Its cationic amphipathic structure facilitates cellular uptake and interaction with mitochondrial components. KLA peptide is valuable for research applications in cancer, inflammation, and neurological diseases, allowing for the exploration of apoptotic pathways and therapeutic interventions. -
Anti-cancerous Peptide
Cr-ACP1 is an anti-cancerous peptide that selectively binds to DNA, inducing cell cycle arrest in the G0-G1 phase. This mechanism triggers apoptosis, making Cr-ACP1 a potent agent against various cancer types. Notably, it demonstrates significant anticancer effects in colon cancer and epidermoid carcinoma research applications. -
Antifungal Peptide
Periplanetasin-2 is an antifungal peptide that exerts its effects primarily through the induction of oxidative stress by generating reactive oxygen species (ROS) and promoting lipid peroxidation. In addition to its antifungal activity, Periplanetasin-2 can also trigger apoptosis in target cells. This compound is valuable for research applications aimed at understanding fungal pathogenesis and evaluating potential therapeutic strategies against fungal infections. -
Fas Mimetic Peptide/Fas/FasL Antagonist
Kp7-6 is a Fas mimetic peptide that acts as a Fas/FasL antagonist. It selectively binds to the Fas receptor and Fas ligand, disrupting receptor complexes and inhibiting downstream apoptotic signaling pathways. This includes the suppression of caspase-8 and caspase-3 activation, thereby preventing β-cell apoptosis and reducing FasL-induced lymphoid cytotoxicity. In preclinical models, Kp7-6 has demonstrated efficacy in reducing tumor volume and enhancing T cell infiltration in pancreatic neuroendocrine tumors, and it has also been shown to protect against concanavalin A-induced liver injury. The compound is relevant for research in type 2 diabetes, inflammation, and cancer biology. -
N-Formyl Peptide Receptor Agonist
WKYMVm is a selective agonist of the N-formyl peptide receptor, specifically FPR2. It exhibits significant anti-inflammatory properties, demonstrating potential to reduce lung and spinal cord injuries. Additionally, WKYMVm influences metabolic pathways by regulating lipid metabolism and leptin signaling, contributing to obesity management. Its role extends to immune cell regulation, where it promotes chemotactic migration and inhibits phagocyte apoptosis. The compound may have variable effects in tumor biology, with potential to either support or hinder tumor progression based on the tumor type. -
Bioactive Peptide
MOTS-c (human) is a bioactive peptide derived from mitochondria that modulates the AMPK/PGC-1α pathway, thereby enhancing insulin sensitivity. This peptide inhibits the folate cycle and de novo purine synthesis, elevating AICAR levels to activate AMPK, which regulates the Nrf2/Keap1 antioxidant pathway and suppresses the NF-κB inflammatory pathway. MOTS-c promotes mitochondrial biogenesis and energy metabolism, resulting in improvements in glucose and lipid metabolism, anti-oxidative stress, and neuroprotection. It is applicable in research studying type 2 diabetes, traumatic brain injury, inflammatory diseases, and age-related metabolic disorders. -
AnxA2 inhibitor
LCKLSL is an N-terminal hexapeptide that functions as a competitive inhibitor of annexin A2 (AnxA2). It effectively blocks the interaction between tissue plasminogen activator (tPA) and AnxA2, thereby inhibiting plasmin generation. Through suppression of the tPA–AnxA2–plasmin pathway, LCKLSL exhibits significant anti-angiogenic activity and may serve as a valuable tool for studying AnxA2-mediated fibrinolytic and vascular processes. - ATWLPPR peptide is a biologically active heptapeptide and a specific antagonist of VEGFR2 (KDR/Flk-1). It binds to VEGFR2, completely blocking VEGF binding and thereby inhibiting VEGF-induced angiogenesis in vivo. ATWLPPR selectively inhibits human endothelial cell proliferation in vitro and fully suppresses VEGF-mediated angiogenesis in vivo.
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C1q/MBL inhibitor
PIC1 PA is a 15-amino-acid peptide and a potent analog of PIC1 that inhibits classical pathway–mediated complement activation. It functions by disrupting the interaction between C1s-C1r-C1r-C1s/MASPs and the collagen-like region (CLR) of C1q or MBL. PIC1 PA specifically binds to the CLR of C1q, with a mean equilibrium dissociation constant (K\_D) of 33.3 nM for purified C1q. -
NRP-1 targeting peptide
tLyP-1 peptide is a neuropilin-1 (NRP-1) targeting peptide with an IC₅₀ of 4 μM and the amino acid sequence CGNKRTR. It specifically binds to NRP-1, enabling selective targeting of tumor cells. -
CRF2 receptor agonist
Urocortin, human, is a 40-amino acid neuropeptide that functions as a selective agonist of the endogenous corticotropin-releasing factor receptor 2 (CRF₂). It exhibits high binding affinity with Kᵢ values of 0.4 nM for human CRF₁, 0.3 nM for rat CRF₂α, and 0.5 nM for mouse CRF₂β. Urocortin plays a role in modulating stress responses, cardiovascular function, and feeding behavior. -
CMKLR1 Agonist
Chemerin-9 (149–157) TFA is a potent peptide agonist of chemokine-like receptor 1 (CMKLR1), exhibiting significant anti-inflammatory activity. It activates downstream signaling pathways by stimulating the phosphorylation of Akt and ERK and promoting reactive oxygen species (ROS) production. Chemerin-9 (149–157) TFA has demonstrated neuroprotective effects, including the amelioration of Aβ₁₋₄₂-induced memory impairment in Alzheimer's disease models. Additionally, it plays important roles in modulating immune responses, regulating adipocyte differentiation, and improving glucose metabolism, making it a valuable tool for research in inflammation, neurodegeneration, and metabolic disorders. -
KRAS/ERK/RAS Inhibitor
LUNA18 is an orally bioavailable cyclic peptide that functions as a dual inhibitor of KRAS and ERK signaling pathways. It disrupts the interaction between RAS and guanine nucleotide exchange factors (GEFs), effectively inhibiting RAS activation and downstream signaling. In RAS-mutated cancer cells, LUNA18 reduces cell proliferation while modulating key signaling nodes, including phosphorylation of ERK and AKT. In preclinical studies, LUNA18 demonstrates potent anticancer activity, particularly in xenograft models, by blocking RAS-driven tumor growth. It shows significant cellular efficacy against cancer cell lines harboring KRAS mutations, including colon, gastric, pancreatic, and non-small cell lung cancers, highlighting its therapeutic potential as a targeted agent for RAS-driven malignancies. -
ERK1/2 activator
mSIRK (G-Protein βγ Binding Peptide) is a cell-permeable peptide that functions as an activator of ERK1/2 signaling, with an EC₅₀ of 2.5–5 μM. It disrupts the interaction between the G-protein α and βγ subunits, promoting dissociation of the α subunit independently of nucleotide exchange. By modulating G-protein signaling, mSIRK enables selective activation of downstream pathways, such as ERK1/2, and serves as a valuable tool for studying G-protein–mediated signal transduction and ERK pathway activation.
