Bactenecin

Catalog No.: A27886
Antimicrobial Peptide
Bactenecin is a potent antimicrobial peptide that exhibits activity primarily through its ability to increase membrane permeability in target microorganisms. This 12-amino acid looped peptide, derived from bovine neutrophils, effectively inhibits the growth of a range of bacteria and yeast, including the fungus Trichophyton rubrum. Bactenecin is particularly relevant for research applications focused on bacterial pathogenesis and biofilm formation, as it has been shown to impede the growth and biofilm development of Burkholderia pseudomallei.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBactenecin is a potent antimicrobial peptide that exhibits activity primarily through its ability to increase membrane permeability in target microorganisms. This 12-amino acid looped peptide, derived from bovine neutrophils, effectively inhibits the growth of a range of bacteria and yeast, including the fungus Trichophyton rubrum. Bactenecin is particularly relevant for research applications focused on bacterial pathogenesis and biofilm formation, as it has been shown to impede the growth and biofilm development of Burkholderia pseudomallei.
Product Information
Catalog NumA27886
FormulaC63H118N24O13S2
Molecular Weight1483.89
CAS Number116229-36-8
SequenceArg-Leu-Cys-Arg-Ile-Val-Val-Ile-Arg-Val-Cys-Arg (Disulfide bridge: Cys3-Cys11)
Sequence shorteningRLCRIVVIRVCR (Disulfide bridge: Cys3-Cys11)
SMILES[H][C@@]1(CCCNC(N)=N)NC(=O)[C@@]([H])(NC(=O)C(NC(=O)[C@@H](NC(=O)[C@@]([H])(NC(=O)[C@]([H])(CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC1=O)C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCCNC(N)=N)[C@@H](C)CC)C(C)C)C(C)C)[C@@H](C)CC |@@:99|
SynonymsBactenecin, bovine
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