Temporin-SHa is an antimicrobial peptide that exhibits broad-spectrum antibacterial activity, effectively targeting both Gram-positive and Gram-negative bacteria, including drug-resistant strains. With a minimum inhibitory concentration (MIC) of 6.25 μM against Listeria ivanovii and 10 μM against Escherichia coli, it is also active against fungal pathogens such as Candida albicans (MIC = 25 μM) and Saccharomyces cerevisiae (MIC = 12 μM). Furthermore, Temporin-SHa demonstrates efficacy against protozoan parasites, including Leishmania infantum and Trypanosoma cruzi, and exhibits antiviral activity against HSV-1, alongside anti-cancer properties that include cytotoxicity against breast cancer (MCF-7) and lung cancer (H460) cell lines.
Temporin-SHa is an antimicrobial peptide that exhibits broad-spectrum antibacterial activity, effectively targeting both Gram-positive and Gram-negative bacteria, including drug-resistant strains. With a minimum inhibitory concentration (MIC) of 6.25 μM against Listeria ivanovii and 10 μM against Escherichia coli, it is also active against fungal pathogens such as Candida albicans (MIC = 25 μM) and Saccharomyces cerevisiae (MIC = 12 μM). Furthermore, Temporin-SHa demonstrates efficacy against protozoan parasites, including Leishmania infantum and Trypanosoma cruzi, and exhibits antiviral activity against HSV-1, alongside anti-cancer properties that include cytotoxicity against breast cancer (MCF-7) and lung cancer (H460) cell lines.
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