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ARF(26–44), cell-permeable

Catalog No.: A31441
Anti-tumor Peptide
ARF(26–44), cell-permeable is a cell-penetrating peptide derived from the p14ARF tumor suppressor protein and functions as an inhibitor of FoxM1. This peptide exhibits marked anti-tumor activity, demonstrating the ability to increase apoptosis and decrease proliferation and angiogenesis in mouse models of hepatocellular carcinoma (HCC). ARF(26–44), cell-permeable serves as a valuable tool for research focusing on tumor therapy and the molecular mechanisms underlying cancer progression.
ARF(26–44), cell-permeable 935732-44-8 Anti-tumor Peptide
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionARF(26–44), cell-permeable is a cell-penetrating peptide derived from the p14ARF tumor suppressor protein and functions as an inhibitor of FoxM1. This peptide exhibits marked anti-tumor activity, demonstrating the ability to increase apoptosis and decrease proliferation and angiogenesis in mouse models of hepatocellular carcinoma (HCC). ARF(26–44), cell-permeable serves as a valuable tool for research focusing on tumor therapy and the molecular mechanisms underlying cancer progression.
Product Information
Catalog NumA31441
FormulaC149H267N69O33S
Molecular Weight3585.22
CAS Number935732-44-8
Sequence{d-(Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg)}-Lys-Phe-Val-Arg-Ser-Arg-Arg-Pro-Arg-Thr-Ala-Ser-Cys-Ala-Leu-Ala-Phe-Val-Asn
Sequence shortening{d-(Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg)}-KFVRSRRPRTASCALAFVN
SMILESC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@H](NC([C@@H](CCCNC(=N)N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCCN)=O)=O)[C@@H](C)C)=O)CCCNC(=N)N)=O)CO)=O)CCCNC(=N)N)=O)CCCNC(=N)N)(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N[C@@H](CC(N)=O)C(O)=O)=O)C(C)C)=O)=O)C)=O)CC(C)C)=O)C)=O)CS)=O)CO)=O)C)=O)[C@@H](C)O)=O)CCCNC(=N)N)=O)CCC2
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