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SHLP2

Catalog No.: A30614
Mitochondrial Derived Peptide
SHLP2 (Small humanin-like peptide 2) is a mitochondrial-derived peptide that primarily targets mitochondrial function. It regulates apoptosis and inhibits cell death through its interaction with mitochondrial complex 1. SHLP2 enhances mitochondrial metabolism by improving respiration and biogenesis, while reducing reactive oxygen species (ROS) and diminishing mtDNA oxidation. Additionally, SHLP2 plays a role in energy homeostasis by activating hypothalamic neurons. This peptide is utilized in research focusing on mitochondrial dysfunction and age-related diseases such as age-related macular degeneration and Parkinson's disease.
SHLP2 1191923-93-9 Mitochondrial Derived Peptide
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Size Price Stock Qty
5mg
$90.00
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10mg
$150.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionSHLP2 (Small humanin-like peptide 2) is a mitochondrial-derived peptide that primarily targets mitochondrial function. It regulates apoptosis and inhibits cell death through its interaction with mitochondrial complex 1. SHLP2 enhances mitochondrial metabolism by improving respiration and biogenesis, while reducing reactive oxygen species (ROS) and diminishing mtDNA oxidation. Additionally, SHLP2 plays a role in energy homeostasis by activating hypothalamic neurons. This peptide is utilized in research focusing on mitochondrial dysfunction and age-related diseases such as age-related macular degeneration and Parkinson's disease.
Product Information
Catalog NumA30614
FormulaC142H214N36O35S
Molecular Weight3017.50
CAS Number1191923-93-9
SequenceMet-Gly-Val-Lys-Phe-Phe-Thr-Leu-Ser-Thr-Arg-Phe-Phe-Pro-Ser-Val-Gln-Arg-Ala-Val-Pro-Leu-Trp-Thr-Asn-Ser
Sequence shorteningMGVKFFTLSTRFFPSVQRAVPLWTNS
SMILESC([C@H](NC([C@@H](NC(=O)[C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]2N(C([C@H](CC3=CC=CC=C3)NC([C@H](CC4=CC=CC=C4)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC5=CC=CC=C5)NC([C@H](CC6=CC=CC=C6)NC([C@@H](NC([C@@H](NC(CNC([C@H](CCSC)N)=O)=O)[C@H](C)C)=O)CCCCN)=O)=O)=O)[C@@H](C)O)=O)CC(C)C)=O)CO)=O)[C@@H](C)O)=O)CCCNC(=N)N)=O)=O)=O)CCC2)CO)=O)C(C)C)=O)CCC(N)=O)=O)CCCNC(=N)N)=O)C)=O)[C@H](C)C)=O)CCC1)CC(C)C)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CO)=O)CC(N)=O)=O)[C@@H](C)O)=O)C=7C=8C(NC7)=CC=CC8
SynonymsSmall humanin-like peptide 2
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