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MEK1 Derived Peptide Inhibitor 1

Catalog No.: A36722
Peptide Inhibitor
MEK1 Derived Peptide Inhibitor 1 is a selective peptide inhibitor targeting MEK1, effectively blocking the in vitro activation of ERK2 with an IC50 value of 30 μM. This compound is valuable for studies focused on the MEK/ERK signaling pathway, allowing researchers to investigate cellular processes regulated by this pathway. Its cell-permeable properties make it suitable for various biological applications in cancer research and signal transduction studies.
MEK1 Derived Peptide Inhibitor 1 355367-87-2 Peptide Inhibitor
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionMEK1 Derived Peptide Inhibitor 1 is a selective peptide inhibitor targeting MEK1, effectively blocking the in vitro activation of ERK2 with an IC50 value of 30 μM. This compound is valuable for studies focused on the MEK/ERK signaling pathway, allowing researchers to investigate cellular processes regulated by this pathway. Its cell-permeable properties make it suitable for various biological applications in cancer research and signal transduction studies.
Product Information
Catalog NumA36722
FormulaC68H118N18O17S
Molecular Weight1491.84
CAS Number355367-87-2
SequenceMet-Pro-Lys-Lys-Lys-Pro-Thr-Pro-Ile-Gln-Leu-Asn-Pro
Sequence shorteningMPKKKPTPIQLNP
SMILESCC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CCSC)[C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(O)=O
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