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DiaPep277

Catalog No.: A37485
HSP60-derived Peptide
DiaPep277 is a 24 amino acid peptide derived from the HSP60 protein, specifically from positions 437-460. This peptide has been shown to halt the progression of β-cell destruction in NOD mice and exerts immune modulatory effects on diabetogenic T cells. DiaPep277 is primarily utilized in research studies focused on diabetes and immune response modulation, making it a valuable tool for understanding autoimmune mechanisms and potential therapeutic interventions.
DiaPep277 179822-83-4 HSP60-derived Peptide
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Size Price Stock Qty
5mg
$150.00
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10mg
$250.00
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDiaPep277 is a 24 amino acid peptide derived from the HSP60 protein, specifically from positions 437-460. This peptide has been shown to halt the progression of β-cell destruction in NOD mice and exerts immune modulatory effects on diabetogenic T cells. DiaPep277 is primarily utilized in research studies focused on diabetes and immune response modulation, making it a valuable tool for understanding autoimmune mechanisms and potential therapeutic interventions.
Product Information
Catalog NumA37485
FormulaC106H180N28O34
Molecular Weight2390.73
CAS Number179822-83-4
Sequence shorteningVLGGGVALLRVIPALDSLTPANED
SMILESC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC(CNC(CNC([C@@H](NC([C@H](C(C)C)N)=O)CC(C)C)=O)=O)=O)=O)C(C)C)=O)C)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(=N)N)=O)[C@H](C)C)=O)[C@H](CC)C)(=O)N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)N2[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)CCC(O)=O)=O)CC(N)=O)=O)C)=O)CCC2)[C@@H](C)O)=O)CC(C)C)=O)CO)=O)CC(O)=O)=O)CC(C)C)=O)C)=O)CCC1
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