A8 peptide

Catalog No.: A37540
Hsp72 Antagonist
A8 peptide is an Hsp72 antagonist that inhibits tumor progression and metastasis. By disrupting the interaction between Hsp72 and TLR2, A8 peptide enhances the sensitivity of cancer cells to apoptosis induced by chemotherapeutic agents, including Cisplatin. This reagent is valuable for research in cancer biology, particularly in exploring mechanisms of drug resistance and metastasis.
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5mg
10mg
50mg
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Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionA8 peptide is an Hsp72 antagonist that inhibits tumor progression and metastasis. By disrupting the interaction between Hsp72 and TLR2, A8 peptide enhances the sensitivity of cancer cells to apoptosis induced by chemotherapeutic agents, including Cisplatin. This reagent is valuable for research in cancer biology, particularly in exploring mechanisms of drug resistance and metastasis.
Product Information
Catalog NumA37540
FormulaC48H66N12O12
Molecular Weight1003.11
CAS Number1140483-17-5
SequenceSer-Pro-Trp-Pro-Arg-Pro-Thr-Tyr
Sequence shorteningSPWPRPTY
SMILESC([C@@H](C(=O)N1[C@H](C(N[C@H](C(=O)N2[C@H](C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(O)=O)=O)[C@@H](C)O)=O)CCC2)CCCNC(=N)N)=O)CCC1)NC(=O)[C@H]4N(C([C@H](CO)N)=O)CCC4)C=5C=6C(NC5)=CC=CC6
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