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Neuropeptide W-30 (human)

Catalog No.: A62164
Stress Mediator
Neuropeptide W-30 (human) is a significant stress mediator in the central nervous system, primarily targeting the hypothalamus-pituitary-adrenal (HPA) axis and modulating sympathetic outflow. As an endogenous ligand for the orphan G-protein-coupled receptors GPR7 and GPR8, Neuropeptide W-30 (human) binds and activates both receptors at comparable effective doses. This compound plays a crucial role in studies related to stress response and neuroendocrine regulation.
Neuropeptide W-30 (human) 383415-80-3 Stress Mediator
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionNeuropeptide W-30 (human) is a significant stress mediator in the central nervous system, primarily targeting the hypothalamus-pituitary-adrenal (HPA) axis and modulating sympathetic outflow. As an endogenous ligand for the orphan G-protein-coupled receptors GPR7 and GPR8, Neuropeptide W-30 (human) binds and activates both receptors at comparable effective doses. This compound plays a crucial role in studies related to stress response and neuroendocrine regulation.
Product Information
Catalog NumA62164
FormulaC165H249N49O37S
Molecular Weight3543.11
CAS Number383415-80-3
SequenceTrp-Tyr-Lys-His-Val-Ala-Ser-Pro-Arg-Tyr-His-Thr-Val-Gly-Arg-Ala-Ala-Gly-Leu-Leu-Met-Gly-Leu-Arg-Arg-Ser-Pro-Tyr-Leu-Trp
Sequence shorteningWYKHVASPRYHTVGRAAGLLMGLRRSPYLW
SMILESC([C@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@H](CC2=CN=CN2)NC([C@H](CC3=CC=C(O)C=C3)NC([C@@H](NC(=O)[C@H]4N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC5=CN=CN5)NC([C@@H](NC([C@H](CC6=CC=C(O)C=C6)NC([C@H](CC=7C=8C(NC7)=CC=CC8)N)=O)=O)CCCCN)=O)=O)C(C)C)=O)C)=O)CO)=O)CCC4)CCCNC(=N)N)=O)=O)=O)[C@@H](C)O)=O)C(C)C)=O)=O)CCCNC(=N)N)=O)C)=O)C)=O)=O)CC(C)C)=O)CC(C)C)=O)CCSC)=O)=O)CC(C)C)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CO)=O)CCC1)CC9=CC=C(O)C=C9)=O)CC(C)C)=O)C(O)=O)C=%10C=%11C(NC%10)=CC=CC%11
SynonymsNPW30, human
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