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(Des-Bromo)-Neuropeptide B (1-23) (human)

Catalog No.: A62163
NPBW Agonist
(Des-Bromo)-Neuropeptide B (1-23) (human) is an agonist for G-protein coupled receptors GPR7 (NPBW1) and GPR8 (NPBW2). It exhibits high affinity binding with inhibition constants (Kis) of 1.2 nM and 341 nM, respectively. This compound is valuable for investigating the neuropeptide signaling pathways and their roles in various physiological processes. It has applications in studies related to neurobiology, metabolic regulation, and receptor pharmacology.
(Des-Bromo)-Neuropeptide B (1-23) (human) 434897-64-0 NPBW Agonist
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
Description(Des-Bromo)-Neuropeptide B (1-23) (human) is an agonist for G-protein coupled receptors GPR7 (NPBW1) and GPR8 (NPBW2). It exhibits high affinity binding with inhibition constants (Kis) of 1.2 nM and 341 nM, respectively. This compound is valuable for investigating the neuropeptide signaling pathways and their roles in various physiological processes. It has applications in studies related to neurobiology, metabolic regulation, and receptor pharmacology.
Product Information
Catalog NumA62163
FormulaC107H162N30O30
Molecular Weight2348.61
CAS Number434897-64-0
SequenceTrp-Tyr-Lys-Pro-Ala-Ala-Gly-His-Ser-Ser-Tyr-Ser-Val-Gly-Arg-Ala-Ala-Gly-Leu-Leu-Ser-Gly-Leu
Sequence shorteningWYKPAAGHSSYSVGRAAGLLSGL
SMILESC([C@@H](C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@H](C(=O)N2[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC3=CN=CN3)C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@@H](CC(C)C)C(O)=O)=O)=O)CO)=O)CC(C)C)=O)CC(C)C)=O)=O)C)=O)C)=O)CCCNC(=N)N)=O)=O)[C@@H](C)C)=O)CO)=O)=O)CO)=O)CO)=O)=O)=O)C)=O)C)=O)CCC2)CCCCN)=O)=O)N)C=5C=6C(NC5)=CC=CC6
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