Catalog No.
Product Name
Application
Product Information
Citations
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PI4KIIIα/HCV Inhibitor
AL-9 is a potent inhibitor of phosphatidylinositol 4-kinase III alpha (PI4KIIIα) with an IC50 of 0.57 μM. It effectively disrupts hepatitis C virus (HCV) replication, making it a valuable tool for studying viral pathogenesis and potential antiviral strategies. Its selective targeting of PI4KIIIα highlights its relevance in research applications focused on HCV infection and related therapeutic developments. -
Akt Kinase Inhibitor
ML-9 Free Base is a selective and potent inhibitor of Akt kinase, demonstrating significant inhibitory effects on myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1). It effectively inhibits MLCK, protein kinase A (PKA), and protein kinase C (PKC) with Ki values of 4 μM, 32 μM, and 54 μM, respectively. Additionally, ML-9 Free Base promotes autophagy by enhancing autophagosome formation while inhibiting their subsequent degradation, making it valuable for research on cellular signaling pathways and autophagic processes. -
AMPK Inhibitor
BAY-3827 is a potent and selective inhibitor of AMP-activated protein kinase (AMPK), exhibiting IC50 values of 1.4 nM at low ATP concentrations (10 μM) and 15 nM at higher ATP concentrations (2 mM). This compound demonstrates over 500-fold selectivity against a wide array of kinases, making it a valuable tool for elucidating AMPK-related pathways. BAY-3827 effectively inhibits the phosphorylation of acetyl-CoA carboxylase 1 and displays significant anti-proliferative effects in androgen-dependent prostate cancer cell lines, supporting its application in cancer research and metabolic studies. -
AMPK Inhibitor
AMPK-IN-3 is a potent and selective inhibitor of AMP-activated protein kinase (AMPK), exhibiting IC50 values of 60.7 nM for AMPK α2, 107 nM for AMPK α1, and 3820 nM for KDR. This compound effectively inhibits AMPK without impacting cell viability or inducing significant cytotoxicity in K562 cells. AMPK-IN-3 is valuable for research focused on cancer biology and the role of AMPK in metabolic regulation and cellular energy homeostasis. -
AMPK Activator
PF-739 is a potent and orally active activator of AMP-activated protein kinase (AMPK). It effectively stimulates 12 heterotrimeric AMPK complexes, leading to a significant reduction in plasma glucose levels. This compound is utilized in research to investigate metabolic disorders and the cellular responses to energy stress. Its role as a non-selective AMPK activator makes it a valuable tool in studies focused on cellular metabolism and energy homeostasis. -
AMPK Activator
Lixumistat acetate is a potent activator of AMP-activated protein kinase (AMPK), promoting increased phosphorylation of AMPK. This compound has demonstrated the ability to mitigate aging-related cognitive decline in animal models. Additionally, Lixumistat acetate acts as a strong inhibitor of oxidative phosphorylation (OXPHOS), making it a valuable tool for research in solid tumor applications. -
AMPK Inhibitor
Chromium(III) acetate functions as an AMPK inhibitor by inhibiting the phosphorylation of AMP-activated protein kinase (AMPK), subsequently promoting lipogenesis. This compound exhibits low toxicity in mammalian models, demonstrated by an LD50 of 2365 mg/kg in rats. It is primarily utilized in research to explore metabolic pathways and the regulation of energy homeostasis. -
AMPK Activator
PXL770 is a selective allosteric activator of AMP-activated protein kinase (AMPK) that enhances metabolic regulation. It has been shown to decrease very long-chain fatty acid (VLCFA) levels, improve mitochondrial respiration, and modulate gene expression in proinflammatory pathways in fibroblasts and lymphocytes related to X-linked adrenoleukodystrophy (ALD). In animal models, PXL770 normalizes plasma VLCFA levels and improves metabolic parameters such as glycemia and insulin sensitivity in diet-induced obesity. This compound serves as a valuable tool for research into ALD, autosomal dominant polycystic kidney disease, and nonalcoholic steatohepatitis (NASH). -
AMPK Activator
MOTS-c (mouse) is a mitochondrial-derived polypeptide that acts as an AMPK activator. It has been shown to modulate pancreatic cell function by reducing insulin secretion and expression in INS-1E cells, while enhancing glucagon secretion in αTC-1 cells. Additionally, MOTS-c (mouse) is effective in decreasing apoptosis in both INS-1E and αTC-1 cell lines. Its ability to counteract diet-induced obesity and insulin resistance highlights its potential in metabolic research. -
AMPK Activator
ZLN024 hydrochloride is an allosteric activator of AMP-activated protein kinase (AMPK). It selectively activates various AMPK heterotrimers, including AMPK α1β1γ1, α2β1γ1, α1β2γ1, and α2β2γ1, with EC50 values of 0.42 µM, 0.95 µM, 1.1 µM, and 0.13 µM, respectively. This compound is instrumental in studies related to energy homeostasis, metabolism, and cellular stress response, making it a valuable tool for researchers investigating AMPK-related pathways in various biological contexts. -
AMPK/Nrf2 Activator
Fortunellin is a flavonoid that acts as an AMPK/Nrf2 activator, derived from the fruits of Fortunella margarita (kumquat). It demonstrates minimal toxicity in murine models and effectively reduces inflammation and reactive oxygen species (ROS) generation in H9C2 cells induced by lipopolysaccharide (LPS). By enhancing the AMPK/Nrf2 pathway, Fortunellin protects against fructose-induced inflammation and oxidative stress, making it a valuable tool for research in diabetic cardiomyopathy. -
AMPK Inhibitor
AMPK-IN-4 is a selective inhibitor of AMP-activated protein kinase (AMPK), targeting both AMPKα1 and AMPKα2 with IC50 values of 393 nM and 141 nM, respectively. This compound is significant in cancer research, facilitating investigations into metabolic regulation and cellular energy homeostasis. Its efficacy in modulating AMPK activity makes it a valuable tool for studying the pathways associated with tumor metabolism and potential therapeutic strategies. -
AMPK Activator
PT1 is an activator of AMPKα1, specifically designed to directly activate the inactive truncated forms of AMPKα1 monomers. This compound enhances AMPK signaling, which plays a critical role in cellular energy homeostasis and metabolism. PT1 is valuable for research applications investigating metabolic disorders, cellular response to stress, and the regulatory mechanisms of energy balance. -
AMPK Substrate
SAMS peptide is a specific substrate for AMP-activated protein kinase (AMPK), facilitating the investigation of AMPK activation and its downstream signaling pathways. This peptide plays a critical role in metabolic research, allowing for the study of energy homeostasis and cellular responses to stress. SAMS is essential for probing the physiological effects of AMPK modulation in various biological contexts. -
AMPK Activator
Lixumistat hydrochloride is a potent AMPK activator that increases AMPK phosphorylation, thereby modulating critical metabolic pathways. This compound has been shown to mitigate aging-associated cognitive impairment in animal models, making it a valuable tool in neurobiology research. Additionally, Lixumistat hydrochloride acts as an effective oxidative phosphorylation (OXPHOS) inhibitor, relevant for studies focusing on solid tumors. -
AMPK Activator
PF-06685249 is a potent allosteric activator of AMP-activated protein kinase (AMPK), exhibiting an EC50 of 12 nM for recombinant AMPK α1β1γ1. This compound has demonstrated efficacy in enhancing renal function in ZSF-1 rats with diabetic nephropathy. PF-06685249 is suitable for research applications targeting metabolic diseases and diabetic nephropathy. -
AMPK Activator
COH-SR4 is a potent AMPK activator that exhibits significant anti-proliferative effects against various cancers, including leukemia, melanoma, breast, and lung cancers. By activating AMPK, COH-SR4 inhibits adipocyte differentiation, making it a valuable tool for studying obesity and related metabolic disorders. This compound is crucial for research aimed at understanding metabolic regulation and the therapeutic potential of targeting AMPK in cancer and metabolic diseases. -
AMPK Activator
Ampkinone is an indirect activator of AMP-activated protein kinase (AMPK), targeting metabolic pathways involved in energy homeostasis. It enhances AMPK activity, which plays a crucial role in regulating cellular energy balance, glucose uptake, and lipid metabolism. This compound is valuable in research applications focused on metabolic disorders, obesity, and diabetes, offering insights into therapeutic strategies for these conditions. -
AMPK Pathway Activator
ALKBH1-IN-3 prodrug is a potent inhibitor of the DNA N6-methyladenine demethylase ALKBH1, functioning primarily through modulation of the AMPK signaling pathway. This prodrug significantly enhances the cellular abundance of 6mA, leading to a reduction in the viability of gastric cancer cells. With its strong cellular activity and favorable in vivo metabolic profile, ALKBH1-IN-3 prodrug is a valuable tool for investigating mechanisms underlying gastric cancer and the role of epigenetic modifications in tumor biology. -
AMPKγ3 Activator
PF-07293893 is an AMPKγ3 activator that enhances cellular energy homeostasis. This compound increases glycogen content, improves lipid oxidation, enhances mitochondrial biogenesis, and promotes vascular repair. It is particularly useful in research applications related to heart failure and metabolic disorders. -
AMPK Activator
AMPK Activator 4 is a selective activator of AMP-activated protein kinase (AMPK) that does not inhibit mitochondrial complex I. This compound enhances AMPK activity specifically in muscle tissues, demonstrating a dose-dependent improvement in glucose tolerance in normal mice. Furthermore, it significantly reduces fasting blood glucose levels and ameliorates insulin resistance in db/db diabetic mice, showcasing its potential as an anti-hyperglycemic agent for diabetes research. -
AMPK Activator/GDF15 Inducer
AMPK Activator 12 is a potent activator of AMP-activated protein kinase (AMPK) and serves as an inducer of growth differentiation factor 15 (GDF15). This compound significantly elevates GDF15 protein levels in human hepatic cells, making it a valuable tool for research into metabolic regulation and cellular stress responses. Its ability to modulate these pathways positions AMPK Activator 12 as a crucial reagent for studies on obesity, diabetes, and related metabolic disorders. -
AMPK Activator
AMPK Activator 1 is a potent activator of AMP-activated protein kinase (AMPK), demonstrating an EC50 of less than 0.1 μM. This compound facilitates the phosphorylation of AMPK, thereby enhancing its activity and promoting cellular energy homeostasis. AMPK Activator 1 is valuable for research applications in metabolism, obesity, diabetes, and cancer studies, where modulation of AMPK signaling pathways may provide therapeutic insights. -
AMPK Activator
AMPK-IN-1 is a potent activator of AMP-activated protein kinase (AMPK), specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM. This compound facilitates the phosphorylation of eEF2 through a mechanism that is independent of mTORC1 signaling. AMPK-IN-1 is valuable for research into metabolic regulation and the cellular energy response, offering insights into the therapeutic potential for conditions related to energy imbalances. -
AMPK Activator
3α-Hydroxymogrol is a triterpenoid derived from Siraitia grosvenorii Swingle, recognized for its ability to activate AMP-activated protein kinase (AMPK). This compound promotes phosphorylation of AMPK, which plays a critical role in cellular energy homeostasis. Research applications include studying metabolic disorders, energy regulation, and potential therapeutic effects in obesity and diabetes. -
AMPK Activator
IQZ23 is an AMPK activator that inhibits adipocyte differentiation through the activation of the AMPK pathway. It demonstrates potent efficacy in reducing triglyceride levels, with an EC50 of 0.033 μM in 3T3-L1 adipocytes. This compound is relevant for research into obesity and associated metabolic disorders, making it a valuable tool for studying metabolic regulation. -
mTOR Inhibitor/AMPK Activator
AMPK/mTOR modulator-1 is a Ginsenoside derivative functioning as both an mTOR inhibitor and AMPK activator. It activates AMPK signaling with a Kd of 4.759 μM, promoting M1-like tumor-associated macrophage polarization while inhibiting M2-like polarization. This compound enhances glycolysis and demonstrates significant anti-inflammatory activity alongside inhibition of tumor progression. AMPK/mTOR modulator-1 is ideal for research focused on colorectal cancer and related metabolic disorders. -
AMPK Activator
AMPK Activator 9 (ZM-6) is a potent activator of AMP-activated protein kinase (AMPK) with an EC50 value of 1.1 µM, primarily targeting the α2β1γ1 subunit. This compound demonstrates significant biological activity in energy metabolism modulation and has applications in research focused on type 2 diabetes. It serves as a valuable tool for elucidating AMPK-related pathways and therapeutic strategies for metabolic disorders. -
AMPK Activator
AMPK activator 8 is a potent activator of AMP-activated protein kinase (AMPK), demonstrating EC50 values of 11, 27, 4, 2, and 4 nM for various AMPK isoforms: rAMPK α1β1γ1, rAMPK α2β1γ1, rAMPK α1β2γ1, rAMPK α2β2γ1, and rAMPK α2β2γ3. This compound is particularly valuable for studying metabolic disorders, specifically type 2 diabetes, by enhancing AMPK activity and modulating glucose metabolism. Its high specificity and efficacy make it an important tool for researchers exploring AMPK-related pathways and therapeutic interventions. -
AMPK Activator
AMPK Activator 6 is a potent activator of AMP-activated protein kinase (AMPK) that enhances its signaling pathway in HepG2 and 3T3-L1 cells. This compound effectively reduces lipid accumulation by significantly lowering triglyceride (TG), total cholesterol (TC), and low-density lipoprotein-C (LDL-C) levels in serum. AMPK Activator 6 is valuable for research into non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome, making it a critical tool for investigating metabolic disorders. -
AMPK Activator
AMPK Activator 10 is a potent activator of AMP-activated protein kinase (AMPK) with an effective concentration (EC150) of 44.3 nM as determined by cell-ELISA. This compound enhances phosphorylation of acetyl-CoA carboxylase (ACC), contributing to its biological effects. AMPK Activator 10 has demonstrated glucose-lowering properties, making it a valuable tool for research in metabolic regulation and related disorders. -
AMPK Activator
JJO-1 is an activator of AMP-activated protein kinase (AMPK) with an EC50 of 1.8 μM. This compound is valuable for research into metabolic disorders, particularly obesity and type 2 diabetes, as it modulates energy homeostasis and enhances glucose uptake. JJO-1 provides a tool for scientists investigating therapeutic strategies aimed at metabolic regulation and improving insulin sensitivity. -
CB1R/AMPK Modulator
CB1R/AMPK Modulator 1 is a potent modulator of the cannabinoid receptor type 1 (CB1R) and adenosine monophosphate-activated protein kinase (AMPK), exhibiting a Ki of 0.81 nM and an IC50 of 3.9 nM for CB1R. This compound effectively activates AMPK, leading to significant reductions in food intake and body weight. Additionally, it enhances glucose tolerance and insulin sensitivity, making it a valuable tool for research in metabolic disorders and obesity-related studies. -
AMPK Activator
DBI-2 is an AMPK activator that targets mitochondrial complex I. It disrupts oxidative phosphorylation (OXPHOS), leading to a reduction in ATP generation within mitochondria. DBI-2 demonstrates significant inhibitory effects on the proliferation of colorectal cancer (CRC) cells, making it a valuable tool for investigating metabolic dysregulation in cancer research. -
AMPK Activator
BI-9774 is a potent activator of 5' AMP-activated protein kinase (AMPK), with an IC50 ranging from 12 to 88 nM. This compound is primarily utilized in research focused on metabolic disorders, such as type 2 diabetes and obesity, as well as in cardiovascular disease studies, including myocardial ischemia and heart failure. Its ability to modulate AMPK activity makes it a valuable tool for investigating therapeutic strategies in these areas. -
AMPK Activator
AMPK Activator 2, a fluorine-containing proguanil derivative, targets the AMP-activated protein kinase (AMPK) signaling pathway, enhancing its activation while downregulating the mTOR/4EBP1/p70S6K pathway. This compound exhibits significant anti-proliferative and anti-migratory effects on various human cancer cell lines, including UMUC3, T24, and A549. AMPK Activator 2 is valuable for research focused on cancer metabolism and therapeutic strategies aimed at metabolic regulation in oncology. -
AMPK Activator
AMPK activator 14 is a selective activator of AMP-activated protein kinase (AMPK). This compound has demonstrated the ability to lower fasted glucose and insulin levels in a db/db mouse model of Type II diabetes. It serves as a valuable tool for research into metabolic disorders and the mechanisms of diabetes management. -
AMPK-α1β1γ1 Activator
AMPK-α1β1γ1 activator 1 is a selective agonist for the AMPK-α1β1γ1 isoform, exhibiting an EC50 value of 38.1 nM. This compound serves as an acyl glucuronide metabolite of an Indole-3-carboxylic acid-based AMPK activator and demonstrates direct binding to the human AMPK complex. Its biological activity makes it a valuable tool for research into metabolic disorders such as diabetic nephropathy. -
AMPK Activator.
Galbacin, an AMPK activator, plays a crucial role in regulating cellular energy homeostasis. Isolated from Myristica fragrans (nutmeg), Galbacin effectively stimulates the AMPK enzyme in differentiated C2C12 cells, demonstrating notable anti-cancer properties by inhibiting the proliferation of lymphocytes and tumor cells. Additionally, it shows promise in preventing weight gain in diet-induced mice models, making it relevant for research into metabolic syndromes, including obesity and type 2 diabetes, as well as cancer studies. -
AMPK Activator
D942 is a potent activator of AMP-activated protein kinase (AMPK) that effectively penetrates cell membranes. This compound also exhibits partial inhibition of mitochondrial complex I. D942 has demonstrated significant anti-proliferative effects on multiple myeloma cells, making it a valuable tool for studies focusing on energy metabolism and cancer cell growth regulation. 연구 응용: D942 can be utilized in investigations of AMPK signaling pathways and their role in cancer metabolism. -
AMPK Activator
AMPK Activator 7 (compound I-3-24) is a potent activator of AMP-activated protein kinase (AMPK) with an EC50 value of 8.8 nM. This compound is valuable for investigating diseases linked to AMPK dysregulation, including type 2 diabetes, metabolic syndrome, obesity, hyperglycemia, hypercholesterolemia, and hypertension. Its selective activation of AMPK facilitates research into metabolic regulation and potential therapeutic interventions for these conditions. -
AMPK Activator
AMPK Activator 11 is a potent activator of AMP-activated protein kinase (AMPK) with nanomolar antiproliferative activity against various colorectal cancers (CRCs). By selectively activating AMPK, this compound enhances oxidative phosphorylation (OXPHOS) and inhibits the growth of RKO xenografts. AMPK Activator 11 is valuable for research in anti-tumor mechanisms and metabolic disease pathways. -
AMPK Regulator
4-PivO-NMT chloride is an indole-derived modulator of the AMPK signaling pathway, specifically influencing neurogenesis and neurite outgrowth by regulating AMPK activity. Its biological activity suggests potential applications in studying neurological disorders, pain mechanisms, and inflammatory responses. This compound serves as a valuable tool for researchers investigating the role of AMPK in various cellular processes. -
AMPK/Nrf2 Activator
Ethyl (E)-ferulate is an activator of the AMPK/Nrf2 signaling pathway, demonstrating significant potential in reducing acute lung injury induced by lipopolysaccharide. This compound exhibits antioxidant and free radical scavenging properties, contributing to its anti-inflammatory and neuroprotective effects. Ethyl (E)-ferulate is a valuable tool for research focused on inflammation and neurodegenerative diseases. -
AMPK Activator
AMPK activator C2 is a potent allosteric activator of AMP-activated protein kinase (AMPK). It enhances AMPK activity, which plays a critical role in cellular energy homeostasis and metabolic regulation. This compound is valuable for investigating the mechanisms underlying epilepsy and convulsions, contributing to the understanding of neuroenergetics and potential therapeutic approaches. -
AMPK Activator
IND 1316 is an orally active AMPK activator that effectively crosses the blood-brain barrier. It exhibits neuroprotective properties in preclinical models of Huntington's disease and is applicable in research concerning neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. This compound serves as a valuable tool for investigating AMPK-related pathways and therapeutic strategies in neurological diseases. -
MEK/PI3K Inhibitor
MEK/PI3K-IN-2 is a potent inhibitor targeting both MEK and PI3K pathways, exhibiting IC50 values of 352 nM for MEK1, 107 nM for PI3Kα, and 137 nM for PI3Kδ. This compound effectively reduces levels of phosphorylated AKT and ERK1/2, demonstrating significant anti-proliferative activity against various tumor cell lines. MEK/PI3K-IN-2 is valuable for research in cancer biology and therapeutic development aimed at disrupting these critical signaling pathways. -
MEK/PI3K Inhibitor
MEK/PI3K-IN-1 is a potent inhibitor targeting MEK and PI3K pathways, exhibiting IC50 values of 124 nM for MEK1, 130 nM for PI3Kα, and 236 nM for PI3Kδ. This compound effectively reduces levels of phosphorylated AKT (pAKT) and ERK1/2 (pERK1/2), demonstrating significant anti-proliferative effects in various tumor cell lines. MEK/PI3K-IN-1 serves as a valuable tool for research in cancer therapeutics and signaling pathway analysis. -
Tubulin Polymerization/Akt Pathway Inhibitor
KS-99 is an inhibitor that targets both tubulin polymerization and the Akt signaling pathway. This compound demonstrates significant biological activity by inhibiting cancer cell proliferation and inducing apoptosis in various cancer cell types. KS-99 is suitable for research applications involving colorectal cancer, breast cancer, lung epithelial cancer, and melanoma. -
PI3Kγ Inhibitor
SH-273 is a potent dual-function compound that acts as a selective inhibitor of PI3Kγ with an IC50 of 7 nM while also stimulating STING function with an EC50 of 100 nM. This unique profile makes SH-273 a valuable tool for investigating signaling pathways involved in pancreatic cancer. Researchers can utilize SH-273 to explore the therapeutic potential of targeting PI3Kγ and enhancing STING-mediated immune responses in cancer models.
