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  • PI3K/Akt/mTOR

PI3K/Akt/mTOR

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Items 1-50 of 860

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  1. A11755
    PF 4708671

    S6 kinase inhibitor

    PF 4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1) that inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 , while having no effect on highly related RSK and MSK kinases.
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  2. A11461
    INK 128 (MLN0128)

    mTOR inhibitor

    INK 128 is a TORC1/2 inhibitor, is also an orally bioavailable inhibitor of raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2) with potential antineoplastic activity.
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  3. A11286
    AKT inhibitor VIII (AKTI-1/2)

    AKT inhibitor

    AKT inhibitor VIII is a cell-permeable and reversible quinoxaline compound that potently and selectively inhibits Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 μM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays).
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  4. A10709
    Perifosine (NSC-639966)

    Akt inhibitor

    Perifosine (also KRX-0401) acts as an Akt inhibitor and a PI3K inhibitor.
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  5. A11153
    CUDC-907 (Fimepinostat)

    PI3K/HDAC inhibitor

    CUDC-907 (Fimepinostat) is a single small molecule inhibitor that targets both PI3K and HDAC. CUDC-907 is more efficacious than either a single PI3K or HDAC inhibitor reference compound or a combination of the two single agents at maximally tolerated doses.
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  6. A11034
    A-674563

    Akt inhibitor

    A-674563 is a B/Akt inhibitor with an IC50 of 14 nM and also shows inhibitory activity against PKA and CDK2 with IC50 of 16 and 46 nM, respectively.
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  7. A11098
    NU-7441 (KU-57788)

    DNA-PK inhibitor

    NU-7441 (KU-57788) is a potent and selective DNA-dependent protein kinase (DNA-PK) inhibitor. The IC50 values are 14, 1700, 5000, >100000 and >100000 nM for DNA-PK, mTOR, PI 3-K, ATM and ATR respectively.
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  8. A12752
    NU7026

    DNA-PK inhibitor

    NU7026 is a novel DNA-dependent protein kinase inhibitor that potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia.
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  9. A13728
    AR-A 014418

    GSK-3 inhibitor

    AR-A 014418 is a selective glycogen synthase kinase 3 (GSK-3) inhibitor (IC50 = 104 nM). Exhibits specificity for GSK-3 over cdk2 and cdk5 (IC50 values are > 100 μM) and over 26 other kinases. Inhibits β-amyloid-mediated neurodegeneration in hippocampal slices.
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  10. A11587
    Torin 1

    mTOR inhibitor

    Torin1 is a potent inhibitor of mTOR with IC50 of 2-10 nM.
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  11. A11586
    Torin 2

    mTOR inhibitor

    Torin 2 is a potent and selective mTOR inhibitor (IC50 = 2.1 nM). Displays 800-fold cellular selectivity for mTOR over PI3K (cellular EC50 values are 0.25 and 200 nM for mTOR and PI3K respectively).
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  12. A10726
    PI-103

    PI3K Inhibitor

    PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of phosphatidylinositol 3-kinase (PI3K) family members with selectivity toward DNA-PK, PI3K (p110α), and mTOR.
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  13. A10547
    LY294002

    PI3K Inhibitor

    LY294002 is a PI3k inhibitor (cell IC50 about 10 μM) and a casein kinase II inhibitor.
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  14. A10507
    KU-60019

    ATM Inhibitor

    KU-60019 is a potent and specific ATM inhibitor with IC50 of 6.3 nM.
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  15. A13328
    ETP-46464

    ATR inhibitor

    ETP-46464 is a potent and selective inhibitor of ATR with IC50 of 25 nM.
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  16. A10731
    PIK-93

    PI4K inhibitor

    PIK 93 selectively inhibits the type III PI 4-kinase enzyme, and small interfering RNA-mediated down-regulation of the individual PI 4-kinase enzymes.
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  17. A13720
    Dorsomorphin 2HCl

    BMP inhibitor

    Dorsomorphin, also known as BML-275, is a selective small molecule inhibitor of BMP signaling, which promotes cardiomyogenesis in embryonic stem cells. Dorsomorphin reverses the mesenchymal phenotype of breast cancer initiating cells by inhibition of bone morphogenetic protein signaling.
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  18. A10989
    WYE-354

    mTOR Inhibitor

    WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. It is a much weaker inhibitor of PI3K α (IC50 = 1026 nM) and other kinases.
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  19. A11148
    BX-795

    PDK-1 inhibitor

    BX-795 is a potent PDK1 inhibitor that blocks PDK1/Akt signaling in tumor cells and inhibits the anchorage-dependent growth of a variety of tumor cell lines in culture or induced apoptosis.
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  20. A11423
    FMK

    RSK inhibitor

    FMK is potent, highly specific and irreversible inhibitor of p90 ribosomal protein S6 kinase RSK1 and RSK2; Fmk binds in the CTKD ATP-binding site and inhibits RSK autophosphorylation at Ser386. Fmk induces significant apoptosis in human FGFR3-expressing, t(4;14)-positive multiple myeloma cells.
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  21. A16352
    AZD8835

    PI3Kα/PI3Kδ inhibitor

    AZD8835 is a potent and selective inhibitor of PI3Kα and PI3Kδ with IC50 of 5.7 nM and 6.2 nM, with selectivity against PI3Kβ (IC50 431 nM) and PI3Kγ (IC50 90 nM).
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  22. A10438
    GSK1059615

    mTOR/PI3K Inhibitor

    GSK1059615 is a potent, reversible, ATP-competitive, thiazolidinedione inhibitor of PI3Kα (IC50 = 2 nM).
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  23. A13289
    Berzosertib (VE-822)

    ATR inhibitor

    Berzosertib (VE-822) is an potent ATR inhibitor.

     
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  24. A19454
    BAY-1895344

    ATR inhibitor

    BAY-1895344 is a potent, orally available and selective ATR inhibitor, with IC50 of 7 nM. Anti-tumor activity.
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  25. A15794
    AZD6738 (Ceralasertib)

    ATR inhibitor

    AZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells.
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  26. A10114
    AZD8055

    mTOR Inhibitor

    AZD8055 is a potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM.
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  27. A14202
    LY-2584702

    p70S6K inhibitor

    LY-2584702 is an orally available inhibitor of p70S6K signaling; inhibits p70S6K and prevents phosphorylation of the S6 subunit of ribosomes.
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  28. A11023
    GDC-0980 (Apitolisib, RG7422)

    mTOR/PI3K Inhibitor

    GDC-0980 (RG7422) is a selective, potent, orally bioavailable inhibitor of Class I PI3 kinase and mTOR kinase (TORC1/2) with in vitro IC50 of 5, 27, 7 and 14 nM for p110 α, β, δ and γ isoforms, respectively.
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  29. A10506
    KU-55933

    ATM inhibitor

    KU-55933 is an ATM inhibitor by suppressing cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.
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  30. A10112
    AZD6482

    PI3K inhibitor

    AZD6482 is a PI3Kbeta inhibitor (IC50=0.021M) used in antithrombotic therapy.
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  31. A11016
    BKM120 (NVP-BKM120, Buparlisib)

    PI3K Inhibitor

    BKM120 (NVP-BKM120) is a bioavailable specific oral pan-class I phosphatidylinositol 3-kinase (PI3K) kinase inhibitor.
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  32. A10172
    CAL-101 (GS-1101, Idelalisib)

    PI3K inhibitor

    CAL-101 is an isoform-selective inhibitor of PI3K that induces apoptosis of chronic lymphocytic leukemia (CLL) cells.
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  33. A10923
    TGX-221

    PI3K Inhibitor

    TGX-221 is a potent, selective, and cell permeable inhibitor of PI3K p110β.
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  34. A11363
    CZC24832

    PI3K inhibitor

    CZC24832 is a selective inhibitor of PI 3-Kinase γ (IC50 = 1.0 μM in a PI 3-Kγ-dependent fMLP-induced neutrophil migration assay).
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  35. A11030
    GSK690693

    AKT inhibitor

    GSK690693 is a novel ATP-competitive, low-nanomolar pan-Akt kinase inhibitor (IC50 values are 2, 13 and 9 nM of Akt1, 2 and 3 respectively).
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  36. A10421
    GDC-0941 (Pictilisib)

    PI3K inhibitor

    GDC-0941 is a potent, selective, orally bioavailable inhibitor of class I PI3 kinase (PI3K) , with IC50 values (nM) of 3, 33, 3, 75, 1230 and 580 for p110 α, β, δ and γ isoforms, DNA-PK and mTOR respectively.
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  37. A10133
    BEZ235 (NVP-BEZ235, Dactolisib)

    PI3K/mTOR Inhibitor

    BEZ235 (NVP-BEZ235) inhibits PI3K and mTOR kinase activity by binding to the ATP-binding cleft of these enzymes.
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  38. A10746
    PP242 (Torkinib)

    mTOR Inhibitor

    PP242 is a potent and selective mTOR inhibitor in both mTORC1 and mTORC2.
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  39. A11064
    YM201636

    PI3K Inhibitor

    YM201636 is a cell-permeable and selective inhibitor of PIKfyve (IC50 = 33 nM).
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  40. A11759
    Capivasertib (AZD5363)

    AKT inhibitor

    Capivasertib (AZD5363) is a potent inhibitor of AKT with pharmacodynamic activity in vivo, has potential to treat a range of solid and hematologic tumors as monotherapy or a combinatorial agent.

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  41. A10374
    Everolimus (RAD001)

    mTOR inhibitor

    Everolimus (RAD-001) is the 40-O-(2-hydroxyethyl) derivative of sirolimus and works similarly to sirolimus as an mTOR inhibitor.
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  42. A11151
    3-Methyladenine

    Autophagy/PI3K Inhibitor

    3-Methyladenine is an inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase).
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  43. A13021
    HS-173

    PI3K Inhibitor

    HS-173, a novel phosphatidylinositol 3-kinase (PI3K) inhibitor, has anti-tumor activity through promoting apoptosis and inhibiting angiogenesis.
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  44. A11328
    BYL719 (Alpelisib)

    PI3K Inhibitor

    BLY719 is an orally bioavailable phosphatidylinositol 3-kinase (PI3K) inhibitor with potential antineoplastic activity.
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  45. A10199
    Laduviglusib (CHIR-99021)

    GSK-3 Inhibitor

    CHIR99021 is an aminopyrimidine derivative that inhibits GSK3α and GSK3β with IC50 values of 10 and 6.7 nM, respectively.
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  46. A11160
    SL 0101-1

    RSK Inhibitor

    SL 0101-1 is a selective inhibitor of p90 ribosomal S6 kinase (RSK) (IC50 = 89 nM for RSK2). It also inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.

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  47. A10729
    PIK-75 hydrochloride

    PI3K Inhibitor

    PIK-75 is an imidazopyridine that selectively inhibits p110α with an IC50 value of 5.8 nM.2 It inhibits p110γ and p110β considerably less effectively with IC50 values of 0.076 μM and 1.3 μM, respectively.
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  48. A11014
    ZSTK474

    PI3K inhibitor

    ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms.
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  49. A14338
    PI-3065

    p110δ inhibitor

    PI-3065 is a small molecule and selective inhibitor of p110δ kinase with an Ki value of 1.5nM and IC50 value of 5nM
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  50. A11784
    GSK2636771

    PI3K Inhibitor

    GSK2636771 is a potent, orally bioavailable, PI3K beta-selective inhibitor.
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