AZD6738 (Ceralasertib)

AZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells.
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Product Name Price Stock Qty
AZD6738 5mg
$100.00
In stock
AZD6738 10mg
$150.00
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AZD6738 25mg
$300.00
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Adooq Products cited in reputable paper
Adooq's AZD6738 (Ceralasertib) has been cited by 2 publications
  • Brian F Kiesel, .et al. , Cancer Chemother Pharmacol, 2022, Feb;89(2):231-242 PMID: 35066692
  • Albert Job, .et al. , Sci Rep, 2020, Nov 3;10(1):18924 PMID: 33144657
  • Biological Activity
    Discription AZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells.
    Targets
    Target Value
    Product Information
    Catalog Num A15794
    Formula C20H24N6O2S
    Molecular Weight 412.51
    CAS Number 1352226-88-0
    SMILES C[C@H]1N(C2=NC(C3=C4C(NC=C4)=NC=C3)=NC(C5([S@](=O)(C)=N)CC5)=C2)CCOC1
    Synonyms AZD-6738, AZD 6738
    Storage

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Solubility
    In vitro (25°C) DMSO 75 mg/mL (181.81 mM)
    Water Insoluble
    Ethanol Warmed: 38 mg/mL
    In vivo 5% DMSO+40% propylene glycol+ddH2O 9 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 24.24 mL 121.21 mL 242.42 mL
    0.5 mM 4.85 mL 24.24 mL 48.48 mL
    1 mM 2.42 mL 12.12 mL 24.24 mL
    5 mM 0.48 mL 2.42 mL 4.85 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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