Signaling Pathway
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| Discription | AZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells. | ||
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| Targets |
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| Catalog Num | A15794 |
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| Formula | C20H24N6O2S |
| Molecular Weight | 412.51 |
| CAS Number | 1352226-88-0 |
| SMILES | C[C@H]1N(C2=NC(C3=C4C(NC=C4)=NC=C3)=NC(C5([S@](=O)(C)=N)CC5)=C2)CCOC1 |
| Synonyms | AZD-6738, AZD 6738 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| In vitro (25°C) | DMSO | 75 mg/mL (181.81 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 38 mg/mL | ||
| In vivo | 5% DMSO+40% propylene glycol+ddH2O | 9 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.24 mL | 121.21 mL | 242.42 mL |
| 0.5 mM | 4.85 mL | 24.24 mL | 48.48 mL |
| 1 mM | 2.42 mL | 12.12 mL | 24.24 mL |
| 5 mM | 0.48 mL | 2.42 mL | 4.85 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
