AZD6738 (Ceralasertib)

AZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells.
Grouped product items
Size Price Stock Qty
1mg
$35.00
In stock
5mg
$90.00
In stock
10mg
$140.00
In stock
25mg
$295.00
In stock
50mg
$410.00
In stock
100mg
$780.00
In stock
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Adooq's AZD6738 (Ceralasertib) has been cited by 6 publications
  • Joshua J Deppas, .et al. , Toxicol Appl Pharmacol, 2025, Jul:500:117375
  • Erika Nakatsuka, .et al. , Transl Oncol, 2024, Sep 12:50:102119 PMID: 39270525
  • Zhiyan Silvia Liu, .et al. , Cancer Res, 2024, Feb 15;84(4):577-597 PMID: 37967363
  • Yang Lim, .et al. , Science, 2023, Sep 22;381(6664) PMID: 37590370
  • Brian F Kiesel, .et al. , Cancer Chemother Pharmacol, 2022, Feb;89(2):231-242 PMID: 35066692
  • Albert Job, .et al. , Sci Rep, 2020, Nov 3;10(1):18924 PMID: 33144657
Biological Activity
DescriptionAZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells.
Targets
TargetValue
Cell Research
Cell LineTypeValueDescriptionReferences
Product Information
Catalog NumA15794
FormulaC20H24N6O2S
Molecular Weight412.51
CAS Number1352226-88-0
SMILESC[C@H]1N(C2=NC(C3=C4C(NC=C4)=NC=C3)=NC(C5([S@](=O)(C)=N)CC5)=C2)CCOC1
SynonymsAZD-6738, AZD 6738
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Solubility
In vitro (25°C) DMSO75 mg/mL (181.81 mM)
WaterInsoluble
EthanolWarmed: 38 mg/mL
In vivo 5% DMSO+40% propylene glycol+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM24.24 mL121.21 mL242.42 mL
0.5 mM4.85 mL24.24 mL48.48 mL
1 mM2.42 mL12.12 mL24.24 mL
5 mM0.48 mL2.42 mL4.85 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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