AZD6738 (Ceralasertib)

Catalog No.: A15794

ATR inhibitor

AZD6738 (Ceralasertib)

AZD6738 (Ceralasertib) Chemical Structure

CAS NO. 1352226-88-0

AZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells.

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5 mg

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10 mg

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25 mg

Regular Price: $300.00

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Albert Job, .et al. The POLD1 R689W variant increases the sensitivity of colorectal cancer cells to ATR and CHK1 inhibitors, Sci Rep, 2020, Nov 3;10(1):18924 PMID: 33144657

Biological Activity

AZD6738 is a potent inhibitor of ATR kinase activity with an IC50 of 1 nM against the isolated enzyme and 74 nM against ATR kinase-dependent CHK1 phosphorylation in cells.
Targets
ATR
1 nM
In vitro (25°C) DMSO 75 mg/mL (181.81 mM)
Water Insoluble
Ethanol Warmed: 38 mg/mL
In vivo 5% DMSO+40% propylene glycol+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.24 mL 121.21 mL 242.42 mL
0.5 mM 4.85 mL 24.24 mL 48.48 mL
1 mM 2.42 mL 12.12 mL 24.24 mL
5 mM 0.48 mL 2.42 mL 4.85 mL

*The above data is based on the productmolecular weight 412.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15794
Actions Inhibitor
CAS No. 1352226-88-0
Formula C20H24N6O2S
M. Wt 412.51
Purity >98%
Synonyms AZD-6738, AZD 6738
SMILES C[[email protected]]1N(C2=NC(C3=C4C(NC=C4)=NC=C3)=NC(C5([[email protected]](=O)(C)=N)CC5)=C2)CCOC1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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