Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
S-acetyl-PEG4-Boc is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the optimal interaction between target proteins and E3 ligases, enhancing the degradation of selected proteins under study. This linker is essential for researchers investigating targeted protein degradation and developing novel therapeutic approaches. -
PROTAC Linkers
Boc-N-PEG5-C2-NHS ester is a PEG-based PROTAC linker designed for applications in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enabling selective degradation pathways. Its versatility makes it valuable for research in targeted protein degradation, thereby assisting in the exploration of novel therapeutic strategies. -
PROTAC Linker
DNP-PEG4-alcohol is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound provides a suitable spacer that enhances the solubility and bioavailability of the resulting PROTACs. It is essential for facilitating the selective degradation of target proteins, making it a valuable tool in drug discovery and development research. -
PROTAC Linkers
Folate-PEG2-amine is a polyethylene glycol (PEG)-derived linker specifically designed for the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the selective degradation of target proteins by linking E3 ligase recruiters to protein targets. Folate-PEG2-amine is particularly useful in cancer research and drug discovery, enabling the development of targeted therapies through enhanced protein management. -
PROTAC Linkers
Boc-NH-PEG2-NH-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis-targeting chimeras). Its bifunctional structure facilitates the conjugation of target proteins and E3 ligases, thereby enhancing protein degradation. This reagent is essential for research applications focused on the development of PROTAC strategies in targeted protein degradation and therapeutic discovery. -
PROTAC Linkers
Bis-propargyl-PEG1 is a PEG-based linker utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features an alkyne group that allows for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions with azide-containing molecules. It serves as a crucial component in the development of targeted protein degradation strategies, enhancing the versatility and effectiveness of PROTAC methodologies in chemical biology research. -
PROTAC Linkers
Azido-PEG2-C1-Boc is a versatile PEG-based linker designed for PROTAC synthesis, utilizing its azide functionality for click chemistry applications. This compound participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkynes and can also engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its efficient conjugation capabilities make it a valuable tool for researchers focusing on targeted protein degradation and protein interaction studies. -
PROTAC Linker
Azido-PEG10-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with alkyne-containing molecules, as well as DBCO or BCN groups, respectively. Azido-PEG10-acid is essential for researchers engaged in targeted protein degradation studies and the development of innovative therapeutic strategies. -
PROTAC Linker
Diethylene Glycol Monobenzyl Ether is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, promoting the targeted degradation of specific proteins in cellular systems. Diethylene Glycol Monobenzyl Ether is a valuable tool in biochemical research focused on protein homeostasis, therapeutic development, and the study of protein-protein interactions. -
PROTAC Linker
NH2-PEG2-methyl acetate is a PEG-based PROTAC linker designed to facilitate the synthesis of PROTAC molecules. This linker enhances the stability and solubility of the resulting compounds, enabling efficient recruitment of E3 ligases for targeted protein degradation. It is particularly valuable in drug discovery and development, helping researchers to explore new therapeutic strategies through the modulation of protein levels in various biological contexts. -
PROTAC Linkers
NH-bis-PEG4 is a polyethylene glycol (PEG)-based linker utilized in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the efficient conjugation of target proteins to E3 ligases, promoting targeted protein degradation. NH-bis-PEG4 is essential in the development of novel therapeutics and can be employed in various research applications within the realms of targeted protein modulation and drug discovery. -
PROTAC Linker
Bromo-PEG7-azide is a polyethylene glycol (PEG)-based linker for PROTAC (Proteolysis Targeting Chimeras) synthesis, facilitating targeted protein degradation. This compound features an azide functional group, enabling its use in click chemistry, specifically copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, making it a versatile tool for researchers in chemical biology and drug development applications. -
PROTAC Linkers
Mal-amido-PEG24-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the development of PROTACs by providing a flexible and hydrophilic spacer that enhances solubility and target engagement. Its unique structure allows for the efficient coupling of ligands to E3 ligase, enabling targeted protein degradation in various research applications, including drug discovery and therapeutic development. -
PROTAC Linker
Bis-propargyl-PEG5 is a PEG-based linker specifically designed for PROTAC synthesis, facilitating targeted protein degradation. This compound exhibits notable utility in constructing synthetic carbohydrate receptors (SCRs) with potential anti-Zika virus activity. As a versatile click chemistry reagent, Bis-propargyl-PEG5 contains an alkyne functional group, allowing for efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, thus expanding its applications in chemical biology and drug development. -
PROTAC Linker
N-Azido-PEG4-N-Boc-N-PEG3-Boc is a PEG-based linker designed for PROTAC synthesis, facilitating targeted protein degradation. Featuring an azide functional group, it participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) and is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) reactions, specifically with DBCO or BCN-containing molecules. This reagent is essential for researchers developing novel therapeutic modalities through targeted degradation pathways. -
PROTAC Linker
m-PEG9-phosphonic acid is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, promoting ubiquitination and subsequent degradation of the target protein. Its utilization is crucial in developing targeted protein degradation strategies for cancer research and other therapeutic applications. -
PROTAC Linker
Aminooxy-PEG3-bromide is a PEG-based linker specifically designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). Its oxime formation capability facilitates the conjugation of target proteins to E3 ligases, enabling the targeted degradation of specific proteins within cellular systems. This compound is valuable for researchers focusing on the development of PROTACs for therapeutic interventions in various diseases. -
Intermediate
FmocNH-PEG2-CH2CONH-PEG2-CH2COOH is a specialized intermediate featuring an extended PEG-like linker designed for bioconjugation applications. This compound enhances solubility and stability for peptide synthesis and drug delivery. Its structural properties facilitate the development of bioactive molecules for various research applications, including targeted therapeutics and diagnostic agents. -
PROTAC Linker
Biotin-PEG3-propargyl is a PEG-based linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an alkyne group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. This reagent facilitates the selective targeting and degradation of proteins, making it a valuable tool in chemical biology and therapeutic research. Biotin-PEG3-propargyl's properties enhance the versatility of PROTAC design and enable advanced studies in protein regulation and cellular processes. -
PROTAC Linker
3,4-Dibromo-Mal-PEG8-Boc is a PEG-based linker specifically designed for PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features a dibromomalonate moiety that facilitates the formation of covalent bonds with target proteins, enabling targeted degradation. Its solubility properties and flexibility make it a valuable tool in the development of advanced therapeutic agents aimed at modulating protein levels in cellular research applications. -
PROTAC Linkers
Fmoc-NMe-PEG4-C2-acid is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins with E3 ligases, promoting targeted degradation pathways in live cells. Its unique structure allows for improved solubility and stability, making it ideal for various research applications in drug discovery and development, particularly for studies on protein homeostasis and targeted therapies. -
PROTAC Linkers
DBCO-NHCO-PEG2-Biotin is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a DBCO (dibenzylcyclooctyne) group that enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its biotin component enhances the attachment of PROTACs to target proteins, facilitating studies on targeted protein degradation and cellular dynamics. DBCO-NHCO-PEG2-Biotin is essential for research applications involving targeted therapeutic strategies and the exploration of protein interactions. -
PROTAC Linkers
Azido-PEG6-C2-Boc is a PEG-based linker designed for the synthesis of PROTACs, functioning primarily through click chemistry mechanisms. This compound features an azide functional group that enables participation in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-bearing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN moieties. Azido-PEG6-C2-Boc is instrumental in the development of targeted protein degradation strategies in chemical biology and therapeutic research. -
PROTAC Linker
Fluorescein-PEG4-acid is a PEG-based linker designed for use in proteolysis-targeting chimeras (PROTACs). This compound facilitates the synthesis of PROTACs by providing properties that enhance cellular retention and targeting efficiency. Its fluorescent characteristics also support applications in imaging studies and monitoring cellular localization of the PROTACs in various biological contexts. -
PROTAC Linkers
m-PEG5-triethoxysilane is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing targeted degradation pathways. Its primary application lies in developing novel therapeutic agents by enabling selective modulation of protein levels in various biological contexts. -
PROTAC Linker
Ethyl acetate-PEG1 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of stable and effective PROTACs, enabling targeted protein degradation in therapeutic applications. Its unique structure enhances solubility and flexibility, making it suitable for a variety of biological research settings focused on protein modulation and regulation. -
PROTAC Linkers
S-acetyl-PEG4-alcohol is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). This reagent enhances the solubility and stability of PROTACs, facilitating target protein degradation. Its application is critical in drug discovery and development, particularly in the field of targeted protein modulation for therapeutic interventions. -
PROTAC linker
Azido-PEG3-O-NHS ester serves as a versatile PEG-based linker for the synthesis of PROTACs, targeting protein degradation pathways. This compound features an azide functional group, facilitating efficient click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted azide-alkyne cycloaddition (SPAAC) reactions, interacting with DBCO or BCN functionalized substrates, making it essential for applications in chemical biology and targeted protein degradation research. -
PROTAC Linker
m-PEG6-Tos is a polyethylene glycol (PEG)-based PROTAC linker that facilitates the synthesis of PROTACs. This linker enhances solubility and improves pharmacokinetic properties, making it suitable for targeted protein degradation applications. It is commonly utilized in research focused on therapeutic protein modulation and drug discovery. -
PROTAC Linkers
Bromoacetamide-PEG3-propargyl is a PEG-based linker designed for use in the synthesis of PROTeolysis TArgeting Chimeras (PROTACs). This compound features an alkyne functional group that allows for copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Bromoacetamide-PEG3-propargyl serves as a valuable component in the development of targeted protein degradation strategies, facilitating the construction of effective chimeric molecules for research in cellular biology and therapeutic development. -
PROTAC Linker
Bromo-PEG5-C2-acid is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (proteolysis targeting chimera) synthesis. This compound facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation. Its application in the development of PROTACs makes it a valuable tool for researchers investigating protein regulation, degradation pathways, and the therapeutic potential of targeted protein modulation. -
PROTAC Linkers
Mal-PEG4-Boc is a bifunctional PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of ligands to E3 ligases, enabling targeted protein degradation in various cellular contexts. Its application extends to chemical biology research, enabling the study of protein function and the development of novel therapeutic strategies. -
PROTAC Linker
Hydroxy-PEG3-NHS is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of targeting ligands to E3 ubiquitin ligases, enabling the selective degradation of specific proteins. Hydroxy-PEG3-NHS is ideal for studies focused on targeted protein degradation, and it plays a crucial role in expanding the toolbox for drug development in therapeutic research. -
PROTAC Linker
Azide-PEG2-MS is a PEG-based linker designed for use in the synthesis of PROTACs, targeting protein degradation pathways. Featuring an azide group, it is a versatile click chemistry reagent that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds. Additionally, Azide-PEG2-MS can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN-containing molecules, facilitating the development of innovative protein-targeting therapies. This linker is ideal for researchers investigating protein degradation and its therapeutic potential. -
PROTAC Linkers
Azido-PEG4-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras) through click chemistry. Featuring an azide group, it readily participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing compounds, as well as strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN functionalized molecules. This versatility makes Azido-PEG4-Boc an essential reagent for constructing targeted protein degradation strategies in chemical biology research. -
PROTAC linker
1,3-Bis-aminooxy propane dihydrochloride serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). Its unique structural properties enhance the ability to selectively degrade target proteins through the ubiquitin-proteasome pathway. This compound is instrumental in chemical biology research for developing targeted protein degradation strategies. -
PROTAC Linker
Acid-PEG1-C2-Boc is a PEG-based PROTAC linker designed to facilitate the synthesis of PROTACs, which are innovative therapeutics for targeted protein degradation. This compound features a carboxylic acid group that enhances solubility and provides a site for conjugation with targeting ligands. Its utility in PROTAC development supports research in drug discovery and the exploration of novel therapeutic interventions. -
PROTAC Linker
Tos-PEG4-acid is a PEG-based PROTAC linker designed to facilitate the development of Proteolysis Targeting Chimeras (PROTACs). This compound enhances the solubility and stability of PROTAC constructs, thereby improving their efficacy in targeted protein degradation research. It is an essential tool for studies aimed at exploring novel therapeutic strategies in oncology and other diseases. -
PROTAC Linker
m-PEG4-aldehyde is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the efficient conjugation of target proteins to E3 ligases, promoting ubiquitination and subsequent degradation of the target protein. Its application in drug discovery and development makes it a valuable tool for researchers investigating targeted protein degradation strategies. -
PROTAC Linkers
Bis-PEG11-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of PROTACs by providing a flexible and hydrophilic spacer that enhances solubility and stability. Its applications extend to targeted protein degradation studies and the development of novel therapeutic agents in chemical biology research. -
PROTAC Linker
Propargyl-PEG4-Boc is a PEG-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound features an alkyne functional group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing partners. Its application is pivotal in the development of targeted protein degradation strategies, facilitating the creation of bifunctional molecules for modulating protein levels in cellular studies. -
PROTAC Linker
1,1,1-Trifluoroethyl-PEG2-propargyl is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an alkyne functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), allowing for efficient conjugation with azide-containing molecules. This compound is instrumental in the development of innovative research tools aimed at targeted protein degradation, enabling studies in cellular biology and therapeutic development. -
PROTAC Linkers
DBCO-PEG9-amine is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring a DBCO moiety, it facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. This compound enables precise and efficient conjugation strategies, making it valuable for applications in targeted protein degradation research. -
PROTAC Linker
m-PEG3-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (PROteolysis TArgeting Chimeras). It facilitates the conjugation of target proteins to E3 ligases, enabling targeted protein degradation. This linker enhances the solubility and pharmacokinetic properties of PROTAC molecules, making it valuable in drug discovery and development within the context of targeted therapies. -
PROTAC Linkers
HO-PEG20-OH is a polyethylene glycol (PEG)-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted protein degradation. Its unique structure enhances solubility and flexibility, making it suitable for various biochemical applications in drug discovery and development. -
PROTAC Linkers
Propargyl-PEG3-methane is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring an alkyne functional group, this compound facilitates the copper-catalyzed azide-alkyne cycloaddition (CuAAc) reaction, enabling efficient conjugation with azide-containing molecules. It is a valuable tool for researchers developing targeted protein degradation strategies. -
PROTAC Linker
Benzyl-PEG4-acid is a PEG-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras. This compound enhances the solubility and stability of PROTACs, enabling effective targeting and degradation of specific proteins within cellular environments. It is primarily utilized in research applications involving targeted protein degradation and the exploration of protein interactions. -
PROTAC Linkers
TCO-PEG3-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of target proteins to E3 ligase, promoting ubiquitination and subsequent degradation. Its versatile structure makes it a valuable tool in chemical biology for the development of targeted protein degradation strategies. -
PROTAC Linker
NH-bis(PEG3-Boc) is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimera) synthesis. It enables efficient conjugation of target proteins and E3 ligases, facilitating selective degradation of unwanted proteins. This compound is particularly valuable in chemical biology and drug discovery research focusing on targeted protein degradation mechanisms. -
PROTAC Linkers
Propargyl-PEG2-beta-D-glucose is a PEG-based linker designed specifically for PROTAC (Proteolysis Targeting Chimera) applications. This compound facilitates the synthesis of PROTACs by providing a suitable chemical scaffold for target protein degradation studies. Its unique structure enhances the versatility and efficacy of PROTACs in biochemical research, enabling targeted therapeutic approaches in fields such as oncology and drug discovery.
