Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
5-[Boc(methyl)amino]pentanal is a bifunctional linker designed for use in the synthesis of PROTACs. This compound features an alkyl amine structure that facilitates robust target protein degradation through the ubiquitin-proteasome system. It is ideal for applications in chemical biology research focused on targeted protein modulation and therapeutic development. -
PROTAC Linker
NHS-PEG4-(m-PEG4)3-ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the connection between targeting ligands and E3 ligase recruiters, enhancing the development of targeted protein degradation strategies. Its application is significant in chemical biology research, particularly in studies aimed at modulating protein levels within cells. -
PROTAC Linkers
Acid-PEG25-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by optimizing the conjugation of various protein tags and ligands. Its use is pivotal in research applications aimed at exploring novel therapeutic strategies through protein modulation and degradation pathways. -
PROTAC Linkers
m-PEG4-sulfonic acid functions as a PEG-based linker for the development of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of targeting ligands and E3 ligases, enhancing the cellular delivery and degradation of specific protein targets. It is particularly valuable for researchers investigating targeted protein degradation mechanisms and developing innovative therapeutic strategies. -
PROTAC Linker
Azide-PEG3-C1-Ala is a PEG-based linker designed for PROTAC (proteolysis-targeting chimera) synthesis. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononyne (BCN) compounds. This versatile linker is essential for studying targeted protein degradation and enhancing the efficacy of therapeutic agents. -
PROTAC Linker
Bis-PEG7-PFP ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis-targeting chimeras). This compound facilitates the development of bifunctional molecules that target specific proteins for degradation, thereby enabling the selective modulation of protein levels within cellular systems. Its unique structure enhances solubility and biocompatibility, making it suitable for various research applications in chemical biology and therapeutic development. -
PROTAC Linkers
Bis-Mal-PEG6 is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This bifunctional molecule facilitates the conjugation of ligands to E3 ligases, enabling targeted degradation of proteins within cells. Its application in PROTAC development supports research in areas such as targeted protein degradation and therapeutic development. -
PROTAC Linkers
MS-PEG12-THP is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This linker facilitates the efficient conjugation of target proteins to E3 ubiquitin ligases, thereby enhancing the degradation of specific proteins in cellular contexts. Its applications include drug development and the study of targeted protein degradation mechanisms, making it a valuable tool in chemical biology and therapeutic research. -
PROTAC Linkers
PEG4-MS is a polyethylene glycol (PEG) based linker designed specifically for use in the synthesis of PROTACs (proteolysis-targeting chimeras). It facilitates the formation of covalent bonds, enhancing the stability and solubility of the resultant PROTAC molecules. PEG4-MS plays a crucial role in targeted protein degradation studies and drug discovery research, aiding in the development of novel therapeutic agents. -
PROTAC Linkers
N-Boc-piperazine-C3-COOH is a chemical linker utilized in the synthesis of PROTAC (Proteolysis Targeting Chimeras) compounds, specifically designed for target protein degradation. This compound facilitates the assembly of bifunctional molecules that engage and ubiquitinate target proteins, promoting their degradation via the proteasome. Its application is significant in research focused on modulating immune checkpoints such as PD-1/PD-L1 through PROTAC PD-1/PD-L1 degrader-1 development. -
PROTAC Linker
N-(Azido-PEG3)-N-bis(PEG1-t-butyl ester) is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with dibenzocyclooctyne (DBCO) or bicyclononynes (BCN), making it a versatile tool for bioconjugation and targeted protein degradation studies. -
PROTAC linker
Boc-piperazine-C13-OTs is a versatile PROTAC linker designed for facilitating targeted protein degradation. This compound enables the construction of bifunctional molecules that can selectively degrade specific proteins, thereby offering significant potential in therapeutic applications. It is particularly useful in the synthesis of NC-R17 for various biochemical and cellular studies in the field of drug discovery and development. -
PROTAC Linkers
N,N'-bis-(Acid-PEG3)-benzothiazole Cy5 is a PEG-based linker designed for use in the synthesis of PROTAC (PROteolysis TArgeting Chimeras) molecules. This compound facilitates the conjugation of target proteins to E3 ligases, promoting the ubiquitination and degradation of specific proteins. Its application in research enhances the development of targeted protein degradation strategies in cellular studies and drug discovery. -
PROTAC Linker
N-(Azido-PEG3)-N-Boc-PEG4-acid is a PEG-based PROTAC linker featuring a terminal azide group. This unique compound enables the synthesis of PROTACs and serves as a versatile click chemistry reagent, capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with compounds containing DBCO or BCN groups, making it a valuable tool for chemical biology research and therapeutic development. -
PROTAC Linker
Amino-PEG8-hydrazide-Boc is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its primary mechanism targets the recruitment of E3 ubiquitin ligases, facilitating the ubiquitination and degradation of specific proteins. This reagent is essential for developing novel therapeutic strategies aimed at modulating protein levels and has significant applications in chemical biology and drug discovery research. -
PROTAC Linkers
Tos-PEG2-CH2-Boc is a PEG-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of molecular conjugates that can effectively engage specific target proteins for degradation via the ubiquitin-proteasome system. It is essential for researchers investigating targeted protein degradation mechanisms and developing novel therapeutic strategies in drug discovery. -
PROTAC Linkers
Bis-PEG17-acid is a polyethylene glycol (PEG)-based linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and stability of PROTACs, facilitating their application in targeted protein degradation research. It is suitable for studies aiming to modulate specific protein levels within cellular systems, contributing to advancements in drug discovery and therapeutic development. -
PROTAC Linker
Bromoacetamido-PEG8-acid is a PEG-based PROTAC linker designed for the synthesis of PROTACs. This compound facilitates the formation of hybrid molecules capable of targeting specific proteins for degradation via the ubiquitin-proteasome pathway. Its structural attributes support enhanced solubility and bioavailability, making it suitable for various applications in chemical biology and therapeutic research. -
PROTAC Linker
Boc-NH-PEG1-Ph-O-CH2COOH is a PROTAC linker designed to facilitate targeted protein degradation by connecting EED-targeting ligands to E3 ligases. This compound enhances the efficacy of PROTACs by optimizing their pharmacokinetic profiles. Its structure enables effective dimerization of target proteins, making it useful in studies related to protein degradation pathways and drug discovery efforts in cancer and other diseases. -
PROTAC Linker
N-(Amino-PEG3)-N-bis(PEG3-acid) is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the assembly of complex biomolecular constructs by providing a flexible and water-soluble connection, enhancing cellular permeability and targeting specificity. It is ideal for applications in drug discovery and development focused on targeted protein degradation. -
PROTAC Linker
S-Acetyl-PEG3-C2-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound enhances the solubility and bioavailability of PROTAC molecules, facilitating targeted protein degradation in various biological contexts. Applications include drug discovery and development, where PROTACs are utilized to selectively degrade disease-associated proteins, thus offering potential therapeutic advantages in oncology and other therapeutic areas. -
PROTAC Linkers
Methyltetrazine-PEG5-triethoxysilane is a PEG-based linker designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, thereby promoting targeted protein degradation. It serves as a crucial component in the development of novel therapeutic strategies aimed at modulating protein expression and activity in various biological systems. -
PROTAC Linker
Cis-3-Aminocyclobutanecarboxylic acid serves as a PROTAC linker, enabling the construction of targeted protein degraders. Its unique structural properties facilitate the development of PROTACs that induce selective protein degradation, a promising approach in therapeutic research. This compound is essential for studies focused on targeted protein modulation and may enhance the efficacy of novel therapeutic strategies. -
PROTAC Linkers
m-PEG10-SH is a polyethylene glycol (PEG)-based linker specifically designed for the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates effective targeting and degradation of specific proteins within cellular environments. Its key biological activity enables the formation of functional PROTACs, making it a valuable tool for researchers investigating novel approaches to protein regulation and targeted therapies. -
PROTAC Linkers
Mal-PEG5-C2-NH2 hydrochloride is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis targeting chimeras (PROTACs). This compound facilitates the assembly of bifunctional molecules that can selectively target and degrade specific proteins via the ubiquitin-proteasome pathway. Its application in PROTAC development enables researchers to explore targeted protein degradation as a therapeutic strategy in various diseases, including cancer and neurodegenerative disorders. -
PROTAC Linker
Amino-Tri-(m-PEG4-ethoxymethyl)-methane is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Its primary role is to facilitate the effective linkage between target proteins and E3 ligases, enhancing the degradation of specific proteins through the ubiquitin-proteasome system. This compound supports research applications in targeted protein degradation, offering a valuable tool for investigating therapeutic strategies in various diseases. -
PROTAC Linkers
Ald-Ph-PEG6-Boc is a PEG-derived PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by linking E3 ligases to the respective target proteins. Its unique structure aids in enhancing the solubility and bioavailability of PROTACs, making it a valuable tool for researchers investigating targeted protein degradation and related therapeutic strategies. -
PROTAC Linker
m-PEG8-C10-phosphonic acid is a PEG-based linker specifically designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the formation of PROTACs by enhancing their solubility and binding properties. It plays a critical role in targeted protein degradation research applications, offering potential insights into therapeutic strategies for modulating protein levels within cells. -
PROTAC Linkers
Fmoc-N-PEG20-acid is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (PROteolysis TArgeting Chimeras) synthesis. This compound facilitates the conjugation of targeting ligands to E3 ubiquitin ligases, enabling the development of novel degron-based therapeutics. Its structure supports effective modulation of protein degradation pathways, making it valuable for research in targeted protein degradation and drug discovery applications. -
PROTAC Linker
Acid-PEG3-SSPy is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, enhancing the targeted degradation of specific cellular proteins. It is valuable in research applications focused on protein modulation and degradation pathways, providing a means to investigate cellular processes and disease mechanisms. -
PROTAC Linkers
Propargyl-PEG3-azide is a PEG-based linker specifically designed for the synthesis of PROTACs. This compound features an azide group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it is capable of undergoing strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN-functionalized compounds. Its versatility makes it a valuable tool in chemical biology and therapeutic research applications involving targeted protein degradation. -
PROTAC Linker
m-PEG3-Sulfone-PEG4-propargyl is a PEG-based linker specifically designed for the development of PROTACs (proteolysis targeting chimeras). This compound features an alkyne group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. m-PEG3-Sulfone-PEG4-propargyl serves as a versatile tool for researchers exploring targeted protein degradation and other chemical biology applications, enabling the precise assembly of bioconjugates and enhancing the efficacy of therapeutic interventions. -
PROTAC Linker
Trans-4-Aminocyclohexylacetic acid serves as an effective PROTAC linker, facilitating the synthesis of proteolysis-targeting chimera molecules. This compound is instrumental in developing PROTACs, such as PROTAC FAK degrader 4, enabling targeted protein degradation in various biological studies. Its application is crucial for research in targeted therapies and cellular regulation mechanisms. -
PROTAC Linkers
m-PEG8-T-Butyl ester is a polyethylene glycol (PEG)-based PROTAC linker designed to facilitate targeted protein degradation. This compound enhances the stability and solubility of PROTACs, enabling efficient synthesis and optimization of bifunctional molecules. m-PEG8-T-Butyl ester is essential for research applications involving the development of novel therapeutic strategies through the modulation of target protein levels in various biological systems. -
PROTAC Linker
2-(Azido-PEG2-amido)-1,3-propandiol is a PEG-based linker designed for the synthesis of PROTACs, facilitating targeted protein degradation. This compound features an azide functional group that allows for cupric ion-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups. Its versatile reactivity makes it a valuable tool for bioconjugation and advanced chemical biology applications in drug discovery. -
PROTAC Linker
(S)-NH2-Pyridine-piperazine(Me)-Boc is a PROTAC linker designed to facilitate the development of targeted protein degradation technologies. It serves a key role in synthesizing PROTAC molecules, such as BTK Degrader-10, which can selectively degrade target proteins via the ubiquitin-proteasome system. This compound is valuable for researchers investigating protein homeostasis, drug discovery, and therapeutics targeting protein regulation. -
PROTAC Linker
N-(Propargyl-PEG4)-N-bis(PEG4-acid) is a PEG-based linker designed for the synthesis of PROTACs (proteolysis targeting chimeras). Its alkyne functional group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating the assembly of complex bioconjugates. This reagent is essential for researchers focusing on targeted protein degradation and the development of tailored therapeutic agents. -
PROTAC Linkers
Tos-PEG5-CH2COOtBu is a PEG-derived PROTAC linker designed for facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the solubility and bioavailability of PROTACs, thereby improving their pharmacological properties. It is particularly useful in research applications aimed at targeted protein degradation, enabling the modulation of protein levels in various biological pathways. -
PROTAC Linkers
HO-PEG7-CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This reagent provides a flexible and hydrophilic connection, facilitating the efficient assembly of target protein-degraders. Its application in various research settings includes the modulation of protein degradation pathways and the study of cellular mechanisms involved in targeted protein removal. -
PROTAC Linkers
Azido-PEG10-Boc is a PEG-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). Its azide functional group enables efficient bioconjugation through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, Azido-PEG10-Boc can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN groups, facilitating the development of targeted therapeutic agents in chemical biology research. -
PROTAC Linkers
Gly-PEG3-endo-BCN is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a bicyclo[6.1.0]non-4-yne (BCN) moiety that enables efficient strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Gly-PEG3-endo-BCN is essential for constructing bifunctional molecules, facilitating targeted protein degradation, and advancing chemical biology research applications. -
PROTAC Linker
Boc-methylglycine-C2-bromine is a PROTAC linker that facilitates the creation of targeted protein degradation molecules. This compound can be utilized in synthesizing PROTACs, such as the PROTAC SMARCA2 degrader-24, enabling selective degradation of specific proteins. Its application is significant in the exploration of targeted protein modulation for therapeutic development and biochemical research. -
PROTAC Linker
1-(Azetidin-3-yl)piperidine serves as a PROTAC (proteolysis-targeting chimera) linker, facilitating the design and synthesis of bifunctional molecules for targeted protein degradation. This compound plays a critical role in the development of innovative therapeutics by enhancing the delivery and specificity of these agents towards disease-associated proteins. Its application in chemical biology supports research in targeted protein modulation and therapeutic discovery. -
PROTAC Linkers
Thiol-PEG12-acid is a polyethylene glycol (PEG) linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of target proteins to E3 ubiquitin ligases, promoting targeted protein degradation mechanisms via the ubiquitin-proteasome pathway. Its applications extend to drug discovery and molecular biology, making it a valuable tool in the development of novel therapeutics targeting disease-related proteins. -
PROTAC Linkers
Benzyl-PEG1-Tos is a PEG-based PROTAC linker designed for the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates the assembly of bifunctional molecules that can selectively target and degrade specific proteins within cells. It serves as a valuable tool in chemical biology research and drug development focused on targeted protein modulation. -
PROTAC Linker
Mal-C4-NH-Boc is an alkyl/ether-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the creation of targeted protein degradation systems by connecting a ligand to an E3 ligase, thereby enabling the selective ubiquitination and subsequent proteasomal degradation of specific proteins. Mal-C4-NH-Boc is suitable for various applications in chemical biology and drug discovery, particularly in studies focused on targeted therapies and protein regulation. -
PROTAC Linker
PC Methyltetrazine-PEG4-NHS carbonate ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). Featuring a tetrazine moiety, this compound facilitates selective interactions through inverse electron demand Diels-Alder (iEDDA) reactions with TCO-containing partners. Its unique chemical structure allows for efficient conjugation and modularity in the design of targeted protein degradation experiments, making it a valuable tool in chemical biology and therapeutic development research. -
PROTAC Linker
endo-BCN-PEG2-NHS ester is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound features a bicyclo[6.1.0]nonyne (BCN) moiety, facilitating strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing substrates. Its application in PROTAC development allows for targeted protein degradation, making it a valuable tool in chemical biology and drug discovery. -
PROTAC Linkers
m-PEG16-COOH is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (Proteolysis Targeting Chimeras) synthesis. This compound facilitates the conjugation of target proteins to E3 ubiquitin ligases, enabling the targeted degradation of specific proteins within cellular systems. It serves as a crucial component in the development of novel therapeutic agents aimed at modulating protein levels, making it valuable for research in cancer therapy and other diseases where protein degradation plays a key role. -
PROTAC Linker
Acid-PEG7-t-butyl ester is a polyethylene glycol (PEG)-derived linker designed for PROTAC (Proteolysis Targeting Chimera) applications. This compound facilitates the synthesis of PROTACs, enabling selective degradation of target proteins through the ubiquitin-proteasome system. Its hydrophilic properties enhance solubility and bioavailability, making it suitable for drug development and therapeutic research in targeted protein degradation strategies.
