K-Ras ligand-Linker Conjugate 3 is designed to selectively target K-Ras through its ligand, combined with a PROTAC linker that facilitates the recruitment of E3 ligases such as VHL, CRBN, MDM2, and IAP. This reagent is instrumental in the development of PROTAC-based degraders, particularly in the synthesis of PROTAC K-Ras Degrader-1, which demonstrates significant degradation efficacy of ≥70% in SW1573 cells. This compound is essential for research applications in targeted protein degradation and cancer therapeutics involving K-Ras.
K-Ras ligand-Linker Conjugate 3 is designed to selectively target K-Ras through its ligand, combined with a PROTAC linker that facilitates the recruitment of E3 ligases such as VHL, CRBN, MDM2, and IAP. This reagent is instrumental in the development of PROTAC-based degraders, particularly in the synthesis of PROTAC K-Ras Degrader-1, which demonstrates significant degradation efficacy of ≥70% in SW1573 cells. This compound is essential for research applications in targeted protein degradation and cancer therapeutics involving K-Ras.
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