BMS-1166-N-piperidine-CO-N-piperazine serves as a targeted ligand-linker conjugate for the PD-1/PD-L1 immune checkpoint pathway. This compound is designed to facilitate the synthesis of a PROTAC PD-1/PD-L1 degrader, exhibiting potent inhibition of the PD-1/PD-L1 interaction with an IC50 value of 39.2 nM. Its applications are particularly relevant in cancer research, where modulating immune checkpoint pathways is critical for therapeutic intervention and study of immune evasion mechanisms.
BMS-1166-N-piperidine-CO-N-piperazine serves as a targeted ligand-linker conjugate for the PD-1/PD-L1 immune checkpoint pathway. This compound is designed to facilitate the synthesis of a PROTAC PD-1/PD-L1 degrader, exhibiting potent inhibition of the PD-1/PD-L1 interaction with an IC50 value of 39.2 nM. Its applications are particularly relevant in cancer research, where modulating immune checkpoint pathways is critical for therapeutic intervention and study of immune evasion mechanisms.
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