BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride is a compound designed for the synthesis of Protein Targeting Chimeras (PROTACs) targeting the PD-1/PD-L1 immune checkpoint. It features a ligand that facilitates binding to PD-1/PD-L1 and includes a PROTAC linker for degradation of target proteins. This compound can be utilized in the development of PROTAC PD-1/PD-L1 degrader-1, which effectively inhibits PD-1/PD-L1 interactions with an IC50 of 39.2 nM, making it a valuable tool for cancer immunotherapy research.
BMS-1166-N-piperidine-CO-N-piperazine dihydrochloride is a compound designed for the synthesis of Protein Targeting Chimeras (PROTACs) targeting the PD-1/PD-L1 immune checkpoint. It features a ligand that facilitates binding to PD-1/PD-L1 and includes a PROTAC linker for degradation of target proteins. This compound can be utilized in the development of PROTAC PD-1/PD-L1 degrader-1, which effectively inhibits PD-1/PD-L1 interactions with an IC50 of 39.2 nM, making it a valuable tool for cancer immunotherapy research.
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