K-Ras ligand-Linker Conjugate 4 functions as a targeted protein ligand-linker conjugate designed for K-Ras. This compound incorporates a ligand to effectively recruit K-Ras and a PROTAC linker that interacts with E3 ligases such as VHL, CRBN, MDM2, and IAP. It serves as a synthetic precursor for PROTAC K-Ras Degrader-1, demonstrating significant biological activity with at least 70% degradation efficacy in SW1573 cells. This conjugate is essential for research into targeted protein degradation and the modulation of K-Ras-related pathways.
K-Ras ligand-Linker Conjugate 4 functions as a targeted protein ligand-linker conjugate designed for K-Ras. This compound incorporates a ligand to effectively recruit K-Ras and a PROTAC linker that interacts with E3 ligases such as VHL, CRBN, MDM2, and IAP. It serves as a synthetic precursor for PROTAC K-Ras Degrader-1, demonstrating significant biological activity with at least 70% degradation efficacy in SW1573 cells. This conjugate is essential for research into targeted protein degradation and the modulation of K-Ras-related pathways.
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