K-Ras ligand-Linker Conjugate 2 is designed to specifically target K-Ras by integrating a selective ligand with a PROTAC linker that facilitates the recruitment of E3 ligases, including VHL, CRBN, MDM2, and IAP. This conjugate serves as a critical precursor for the synthesis of PROTAC K-Ras Degrader-1, demonstrating significant biological activity by achieving ≥70% degradation efficiency in SW1573 cancer cells. It is a valuable tool for research focused on protein degradation and therapeutic strategies for K-Ras-driven cancers.
K-Ras ligand-Linker Conjugate 2 is designed to specifically target K-Ras by integrating a selective ligand with a PROTAC linker that facilitates the recruitment of E3 ligases, including VHL, CRBN, MDM2, and IAP. This conjugate serves as a critical precursor for the synthesis of PROTAC K-Ras Degrader-1, demonstrating significant biological activity by achieving ≥70% degradation efficiency in SW1573 cancer cells. It is a valuable tool for research focused on protein degradation and therapeutic strategies for K-Ras-driven cancers.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
