K-Ras ligand-Linker Conjugate 1 is designed to target the K-Ras protein through a specific ligand, while also incorporating a PROTAC linker that facilitates the recruitment of E3 ligases such as VHL, CRBN, MDM2, and IAP. This reagent is essential for the synthesis of PROTAC K-Ras Degrader-1, a potent degrader that demonstrates greater than 70% degradation efficacy in SW1573 cells. It serves as a valuable tool for researchers investigating K-Ras-related pathways and exploring targeted protein degradation strategies.
K-Ras ligand-Linker Conjugate 1 is designed to target the K-Ras protein through a specific ligand, while also incorporating a PROTAC linker that facilitates the recruitment of E3 ligases such as VHL, CRBN, MDM2, and IAP. This reagent is essential for the synthesis of PROTAC K-Ras Degrader-1, a potent degrader that demonstrates greater than 70% degradation efficacy in SW1573 cells. It serves as a valuable tool for researchers investigating K-Ras-related pathways and exploring targeted protein degradation strategies.
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