Desmorpholinyl Quizartinib-PEG2-COOH is a conjugate designed for targeted protein degradation, specifically targeting the FLT-3 receptor. This compound incorporates a FLT-3 ligand and a PEG-based PROTAC linker, facilitating the synthesis of PROTAC FLT-3 degrader 1, which effectively degrades FLT-3 internal tandem duplication (ITD) variants with an IC50 of 0.6 nM. This reagent is valuable for research applications focusing on targeted therapy and protein degradation mechanisms in hematological malignancies.
Desmorpholinyl Quizartinib-PEG2-COOH is a conjugate designed for targeted protein degradation, specifically targeting the FLT-3 receptor. This compound incorporates a FLT-3 ligand and a PEG-based PROTAC linker, facilitating the synthesis of PROTAC FLT-3 degrader 1, which effectively degrades FLT-3 internal tandem duplication (ITD) variants with an IC50 of 0.6 nM. This reagent is valuable for research applications focusing on targeted therapy and protein degradation mechanisms in hematological malignancies.
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