K-Ras ligand-Linker Conjugate 5 is designed to target the K-Ras protein through a ligand and incorporates a PROTAC linker that facilitates the recruitment of E3 ligases, including VHL, CRBN, MDM2, and IAP. This compound serves as a vital component in the synthesis of PROTAC K-Ras Degrader-1, a robust degrader that demonstrates ≥70% degradation efficacy in SW1573 cells. Its application in targeted protein degradation research makes it a valuable tool for investigating K-Ras-related pathways in oncology.
K-Ras ligand-Linker Conjugate 5 is designed to target the K-Ras protein through a ligand and incorporates a PROTAC linker that facilitates the recruitment of E3 ligases, including VHL, CRBN, MDM2, and IAP. This compound serves as a vital component in the synthesis of PROTAC K-Ras Degrader-1, a robust degrader that demonstrates ≥70% degradation efficacy in SW1573 cells. Its application in targeted protein degradation research makes it a valuable tool for investigating K-Ras-related pathways in oncology.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
