K-Ras ligand-Linker Conjugate 6 is designed to selectively target K-Ras through its ligand-recruiting moiety, while featuring a PROTAC linker that facilitates the recruitment of E3 ligases such as VHL, CRBN, MDM2, and IAP. This compound is instrumental in the synthesis of PROTAC K-Ras Degrader-1, a potent degrader that demonstrates at least 70% degradation efficacy in SW1573 cells. Its unique properties make it an essential tool for researchers studying K-Ras signaling and targeted protein degradation in cancer biology.
K-Ras ligand-Linker Conjugate 6 is designed to selectively target K-Ras through its ligand-recruiting moiety, while featuring a PROTAC linker that facilitates the recruitment of E3 ligases such as VHL, CRBN, MDM2, and IAP. This compound is instrumental in the synthesis of PROTAC K-Ras Degrader-1, a potent degrader that demonstrates at least 70% degradation efficacy in SW1573 cells. Its unique properties make it an essential tool for researchers studying K-Ras signaling and targeted protein degradation in cancer biology.
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