Adamantane-Butyl alcohol

Catalog No.: A84653
PROTAC E3 Ligases and Linkers
Adamantane-Butyl alcohol serves as a crucial linker for PROTACs targeting E3 ligases, specifically in the degradation of the CDK8-cyclin C complex. This compound facilitates targeted protein degradation, thereby enhancing the modulation of cellular processes and offering a strategic approach in research applications such as cancer biology and therapeutic development. Its selective and persistent nature makes it an integral component in the design of novel protein degraders.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAdamantane-Butyl alcohol serves as a crucial linker for PROTACs targeting E3 ligases, specifically in the degradation of the CDK8-cyclin C complex. This compound facilitates targeted protein degradation, thereby enhancing the modulation of cellular processes and offering a strategic approach in research applications such as cancer biology and therapeutic development. Its selective and persistent nature makes it an integral component in the design of novel protein degraders.
Product Information
Catalog NumA84653
FormulaC13H22O
Molecular Weight194.31
CAS Number31685-38-8
SMILESOCCCC12CC3CC(CC(C3)C2)C1
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