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Fig. 1 · Structure
Cat. No.
A12171
CAS No.
953778-58-0
Formula
C20H23F3N2O2
Mol. Weight
380.4

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MK-8998

Cat. No. A12171 CAS 953778-58-0

T-type calcium channel inhibitor

MK-8998 (compound 33) is a potent and selective inhibitor of the T-type calcium channel.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
HEK293 IC50 1.2 nM Inhibition of CaV 3.1 channel (unknown origin) expressed in HEK293 cells by FLEPR Ca2+ flux assay [PMID: 27933950]
HEK293 IC50 1.2 nM Inhibition of T-type calcium channel Cav3.1 (unknown origin) expressed in HEK293 cells assessed as calcium influx by Fluo-4-AM dye-based FLIPR assay [PMID: 27579577]
HEK293 IC50 1.5 nM Inhibition of CaV 3.3 channel (unknown origin) expressed in HEK293 cells by FLEPR Ca2+ flux assay [PMID: 27933950]
HEK293 IC50 1.5 nM Inhibition of T-type calcium channel Cav3.3 (unknown origin) expressed in HEK293 cells assessed as calcium influx by Fluo-4-AM dye-based FLIPR assay [PMID: 27579577]
HEK293 IC50 8.2 nM Inhibition of CaV 3.2 channel (unknown origin) expressed in HEK293 cells by FLEPR Ca2+ flux assay [PMID: 27933950]
HEK293 IC50 8.2 nM Inhibition of recombinant T-type calcium channel Cav3.2 (unknown origin) expressed in HEK293 cells assessed as inhibition of CaCl2-induced calcium influx preincubated for 3 mins prior CaCl2 addition by Fluo-4-AM dye-based FLIPR assay [PMID: 27579577]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 953778-58-0
Applications T-type calcium channel inhibitor
Formula C20H23F3N2O2
Molecular Weight 380.4
SMILES
O=C(N[C@@H](C1=NC=C(OCC(F)(F)F)C=C1)C)CC2=CC=C(C(C)C)C=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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