FAK

Inhibitory Selectivity
Catalog No.Inhibitor Name FAKOther
A12580PF-00562271
****
CDK2/CyclinE,CDK3/CyclinE,CDK1/CyclinB
A11192PF-562271
****
CDK2/CyclinE,CDK3/CyclinE,CDK1/CyclinB
A11235PF-573228
*
A11507TAE226
**
Insulin Receptor,IGF-1R,c-Met
A11171PF-03814735
*
Aurora A,Aurora B,FLT1
A11142PF-431396
**
A13140PND-1186
****
A11929Defactinib
A15543CEP-37440
**
ALK
A15765GSK2256098
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A15765 SALE

GSK2256098

FAK inhibitor
GSK2256098 is a focal adhesion kinase-1 (FAK) inhibitor with potential antiangiogenic and antineoplastic activities.
A11507 SALE

NVP-TAE 226

FAK inhibitor
NVP-TAE226 is a potent FAK inhibitor with IC50 of 5.5 nM and modestly potent to Pyk2(IC50=3.5 nM); 10- to 100-fold less potent against InsR, IGF-1R, ALK, and c-Met.
A15543

CEP-37440

FAK/ALK inhibitor
CEP-37440 is a novel potent and selective Dual FAK/ALK inhibitor with IC50 s of 2.3 nM (FAK) and 120 nM(ALK cellular IC50 in 75% human plasma).
A13461

PF-4618433

PYK2/FAK inhibitor
PF-4618433 shows improved PYK2 potency, reduced p38 activity, and superior overall selectivity relative to the prototype BIRB796.
A13140

PND-1186

FAK inhibitor
PND-1186 is a potent FAK inhibitor with IC50 of 1.5 nM.
A12580

PF-00562271

FAK inhibitor
PF-00562271 is the benzenesulfonate salt of PF-562271, which is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 with IC50 of 1.5 nM and 14 nM, respectively.
A11929 SALE

PF-04554878 (Defactinib)

FAK inhibitor
PF-04554878 is a novel FAK kinase inhibitor that decreases growth and induces apoptosis in pancreatic neuroendocrine tumor cells
A11235 SALE

PF 573228

FAK Inhibitor
PF 573228 is a potent and selective inhibitor of focal adhesion kinase (FAK) (IC50 = 4 nM).
A11171

PF-03814735

Aurora A/B Kinase inhibitor
PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.
A11142 SALE

PF 431396

FAK/PYK2 inhibitor
PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively).
A11192 SALE

PF-562271

FAK inhibitor
PF-562271 is an orally bioavailable small molecule and ATP-competitive focal adhesion kinase (FAK) inhibitor with potential antineoplastic and antiangiogenic activities.

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