Defactinib

Catalog No.: A21958

FAK inhibitor

Defactinib

Defactinib Chemical Structure

CAS NO. 1073154-85-4

Defactinib (VS-6063; PF-04554878) is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities.

Availability: In stock

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5 mg

Regular Price: $76.00

Special Price $60.80

10 mg

Regular Price: $130.00

Special Price $104.00

50 mg

Regular Price: $386.00

Special Price $308.80

100 mg

Regular Price: $773.00

Special Price $618.40

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Biological Activity

Defactinib (VS-6063; PF-04554878) is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities.
In vitro (25°C) DMSO Warmed: 5 mg/mL (9.79 mM)
Water Insoluble
Ethanol Insoluble
In vivo 5% DMSO+50% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.59 mL 97.95 mL 195.89 mL
0.5 mM 3.92 mL 19.59 mL 39.18 mL
1 mM 1.96 mL 9.79 mL 19.59 mL
5 mM 0.39 mL 1.96 mL 3.92 mL

*The above data is based on the productmolecular weight 510.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21958
Actions Inhibitor
CAS No. 1073154-85-4
Formula C20H21F3N8O3S
M. Wt 510.49
Purity >98%
Synonyms VS-6063, VS 6063, VS6063; PF-04554878, PF04554878, PF04554878
SMILES O=C(NC)C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=NC=CN=C3N(C)S(=O)(C)=O)=N2)C=C1
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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