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PF 431396

Catalog No.: A11142

FAK/PYK2 inhibitor

PF 431396

PF 431396 Chemical Structure

CAS NO. 717906-29-1

PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively).

Availability: In stock

Package Price Qty
10 mg
$80.00
25 mg
$160.00
50 mg
$280.00
100 mg
$480.00
10mM * 1mL in DMSO
$105.00
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Biological Activity

PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively).
Targets
FAK PYK2
2 nM11 nM
In vitro DMSO 94 mg/mL (185.58 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.74 mL 98.72 mL 197.43 mL
0.5 mM 3.95 mL 19.74 mL 39.49 mL
1 mM 1.97 mL 9.87 mL 19.74 mL
5 mM 0.39 mL 1.97 mL 3.95 mL

*The above data is based on the productmolecular weight 506.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11142
Actions Inhibitor
CAS No. 717906-29-1
Formula C22H21F3N6O3S
M. Wt 506.5
Purity >98%
Synonyms PF-431396
SMILES CN(C1=CC=CC=C1CNC2=NC(=NC=C2C(F)(F)F)NC3=CC4=C(C=C3)NC(=O)C4)S(=O)(=O)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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