Sirtuins

Inhibitory Selectivity
Catalog No.Inhibitor Name SIRT1SIRT2SIRT3SirtuinOther
A10377Selisistat (EX 527)
****
A12226Sirtinol
*
**
A15902SirReal2
****
A14221Splitomicin
**
A14225AGK2
***
A12305Tenovin-6
***
*
p53

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



12 Item(s)

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Catalog No. Product Name Application Product Information
A15902 SALE

SirReal2

Selective SIRT2 inhibitor
SirReal2 is a potent and selective Sirt2 inhibitor with IC50 of 140 nM.
A15247

SRT 1720

SIRT1 Activator
SRT 1720 is a selective activator of human SIRT1 (EC1.5 = 0.16 μM) versus the closest sirtuin homologues, SIRT2 and SIRT3 (SIRT2: EC1.5 = 37 uM??SIRT3: EC1.5 > 300 uM).
A10862 SALE

SRT1720 HCl

SIRT1 Activator
SRT1720 is an inhibitor developed intended as a small-molecule activator of the sirtuin subtype SIRT1.
A14370

AK-1

SIRT2 inhibitor
AK-1 inhibits SIRT2 selectively over SIRT1 and SIRT3.
A14225 SALE

AGK2

SIRT2 inhibitor
AGK2 is a potent, and selective SIRT2 inhibitor with IC50 of 3.5 μM.
A14188

SRT2104 (GSK2245840)

SIRT1 activator
SRT2104 (GSK2245840) is a selective SIRT1 activator involved in the regulation of energy homeostasis. Phase 2.
A12527

Inauhzin

SIRT1 inhibitor
Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress.
A12305 SALE

Tenovin-6

p53 activator
Tenovin-6 is a analog of tenovin-1. Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC50 values of 21, 10, and 67 uM, respectively.
A12904

AK-7

SIRT2 inhibitor
AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM).
A10388 SALE

Fisetin (Fustel)

-
Fisetin is a flavonol, a structurally distinct chemical substance that belongs to the flavonoid group of polyphenols. It can be found in many plants, where it serves as a colouring agent. Possible anti-aging, anti-inflammatory, anti-cancer, and anti-viral properties of fisetin are under active scientific investigation.
A10377 SALE

EX 527 (Selisistat)

SIRT1 inhibitor
EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor with IC50 of 38 nM in a cell-free assay.
A12226 SALE

Sirtinol

sirtuin inhibitor
Sirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases. It is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.

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