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Sirtinol

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sirtuin inhibitor

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Catalog No. A12226

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
Sirtinol 10mg A12226-10

Regular Price: €76.00

Special Price: €68.40

Sirtinol 25mg A12226-25

Regular Price: €161.50

Special Price: €145.35

Sirtinol 50mg A12226-50

Regular Price: €285.00

Special Price: €256.50

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

Sirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases. It is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.

Sirtinol

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Chemical Information

Catalog Num A12226
Actions Inhibitor
M. Wt 394.47
Formula C26H22N2O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 410536-97-9
Synonyms Sir Two Inhibitor Naphthol
SMILES O=C(N([H])C(C1=CC=CC=C1)C)C(C=CC=C2)=C2/N=C/C3=C(O)C=CC4=C3C=CC=C4

Biological Activity

Description
Sirtinol is a cell-permeable, specific inhibitor of sirtuin NAD-dependant histone deacetylases. It is a specific SIRT1 and SIRT2 inhibitor with IC50 of 131 μM and 38 μM in cell-free assays, respectively.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.35 mL 126.75 mL 253.5mL
0.5 mM 5.07 mL 25.35 mL 50.7 mL
1 mM 2.54 mL 12.68 mL 25.35 mL
5 mM 0.51 mL 2.54 mL 5.07 mL

*The above data is based on the productmolecular weight 394.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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