SRT 2183

Catalog No.: A12150

Sirtuin-1 (SIRT1) activator

SRT 2183

SRT 2183 Chemical Structure

CAS NO. 1001908-89-9

SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels.

Availability: In stock

Package Price Qty
5 mg
$122.00
10 mg
$209.00
50 mg
$621.00
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Biological Activity

SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels.
In vitro DMSO 86 mg/mL (183.53 mM)
Water Insoluble
Ethanol 3 mg/mL (6.4 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.34 mL 106.71 mL 213.42 mL
0.5 mM 4.27 mL 21.34 mL 42.68 mL
1 mM 2.13 mL 10.67 mL 21.34 mL
5 mM 0.43 mL 2.13 mL 4.27 mL

*The above data is based on the productmolecular weight 468.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12150
Actions Activator
CAS No. 1001908-89-9
Formula C27H24N4O2S
M. Wt 468.57
Purity >98%
Synonyms SRT2183, SRT-2183
SMILES O=C(NC1=C(C2=CN3C(SC=C3CN4CC[[email protected]@H](O)C4)=N2)C=CC=C1)C(C=C5)=CC6=C5C=CC=C6
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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