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$0.00 Biological Activity
SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.34 mL | 106.71 mL | 213.42 mL |
| 0.5 mM | 4.27 mL | 21.34 mL | 42.68 mL |
| 1 mM | 2.13 mL | 10.67 mL | 21.34 mL |
| 5 mM | 0.43 mL | 2.13 mL | 4.27 mL |
*The above data is based on the productmolecular weight 468.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12150 |
|---|---|
| Actions | Activator |
| M. Wt | 468.57 |
| Formula | C27H24N4O2S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 1001908-89-9 |
| Synonyms | SRT2183, SRT-2183 |
| SMILES | O=C(NC1=C(C2=CN3C(SC=C3CN4CC[[email protected]@H](O)C4)=N2)C=CC=C1)C(C=C5)=CC6=C5C=CC=C6 |
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