PROTAC Sirt2 Degrader-1

Catalog No.: A20005

Sirt2 degrader

PROTAC Sirt2 Degrader-1

PROTAC Sirt2 Degrader-1 Chemical Structure

CAS NO. 2098487-75-1

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase.

Availability: In stock

Package Price Qty
5 mg
$810.00
10 mg
$1,395.00
50 mg
$4,140.00
100 mg
$8,280.00
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Biological Activity

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 11.72 mL 58.62 mL 117.24 mL
0.5 mM 2.34 mL 11.72 mL 23.45 mL
1 mM 1.17 mL 5.86 mL 11.72 mL
5 mM 0.23 mL 1.17 mL 2.34 mL

*The above data is based on the productmolecular weight 852.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A20005
Actions Degrader
CAS No. 2098487-75-1
Formula C40H40N10O8S2
M. Wt 852.94
Purity >98%
SMILES O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3OCC(NCCCCN4C=C(COC5=CC(CC6=CN=C(NC(CSC7=NC(C)=CC(C)=N7)=O)S6)=CC=C5)N=N4)=O
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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