Catalog No.
Product Name
Application
Product Information
Citations
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Racemic Isomer of Beraprost sodium
(Rac)-Beraprost sodium is a racemic isomer of the prostacyclin analog Beraprost sodium, primarily targeting prostacyclin receptors. It effectively inhibits calcium release from intracellular stores, promoting smooth muscle relaxation and vasodilation. With notable vasodilatory, antiplatelet, and cytoprotective properties, (Rac)-Beraprost sodium serves as a valuable tool for research into cardiovascular diseases, including thromboangiitis obliterans and atherosclerosis. -
Prostaglandin FP Receptor Agonist
Bimatoprost acid is a potent agonist of the prostaglandin FP receptor. As the acid hydrolysis product of Bimatoprost, it exhibits significant biological activity in modulating intraocular pressure. This compound is utilized in research applications aimed at investigating ocular pharmacology and the mechanisms underlying glaucoma treatments. -
the Trans Isomer of Latanoprost
trans-Latanoprost is the trans isomer of Latanoprost, primarily targeting the prostaglandin FP receptor. This compound exhibits potent biological activity in reducing intraocular pressure, making it a valuable research tool in the study of glaucoma and other ocular conditions associated with elevated eye pressure. Its unique structural properties allow for potential exploration in therapeutic applications and ocular pharmacology. -
DP(2) Receptor Agonist
15(R)-Prostaglandin D2 is an agonist of the DP(2) receptor, identified as a prostatic hormone with anti-inflammatory properties. This compound enhances actin polymerization in human eosinophils and elevates cAMP levels in platelets, making it valuable for research in inflammation and immune response mechanisms. Its utility extends to studying the role of prostaglandins in various biological processes and pathways. -
Thromboxane A2 Receptor Antagonist
Sulotroban is a selective antagonist of the thromboxane A2 receptor (TXA2). It effectively inhibits vasoconstriction induced by carbocyclic thromboxane A2 and endoperoxides, while also demonstrating the ability to inhibit platelet aggregation. This compound is of particular interest in cardiovascular research, where modulation of thromboxane A2 signaling may hold therapeutic potential for various vascular conditions. -
Thromboxane A2 Receptor Ligand
8-Isoprostaglandin E2 (iPE2-III) is a potent ligand for the thromboxane A2 receptor (TP). It is known to induce vasoconstriction and promote platelet aggregation, making it significant in vascular biology and hemostasis research. Additionally, 8-Isoprostaglandin E2 enhances the RANKL-dependent osteoclastic activity of marrow hematopoietic precursors through the cAMP signaling pathway, positioning it as a valuable agent in studies of bone metabolism and related disorders. -
Prostaglandin E3/F Receptor Agonist
Sepetaprost is a dual agonist of the prostaglandin E3 and F receptors, primarily targeting ocular health. It exhibits significant biological activity in reducing intraocular pressure, making it a valuable compound for research into ocular hypertension and open-angle glaucoma. This agent is instrumental in studying mechanisms of action related to eye disorders and potential therapeutic strategies. -
Prostaglandin Receptor Antagonist
BAY-6672 is a potent and selective antagonist of the human Prostaglandin F (FP) receptor, exhibiting an IC50 value of 11 nM. This compound effectively inhibits FP receptor-mediated signaling, making it a valuable tool for studies of prostaglandin-related biological processes. BAY-6672 is primarily utilized in research exploring inflammation, reproductive biology, and cardiovascular functions associated with prostaglandin signaling pathways. -
DP Receptor Antagonist
Laropiprant sodium is a potent and selective antagonist of the DP receptor, exhibiting Ki values of 0.57 nM for the DP receptor and 2.95 nM for the TP receptor. This compound is utilized in research to explore its effects on inflammatory processes and vascular function due to its role in modulating prostaglandin signaling. Its high selectivity makes it a valuable tool for investigating DP receptor-mediated pathways in various biological contexts. -
Prostaglandin Analog
17-Trifluoromethylphenyl trinor prostaglandin F2α ethyl amide is a lipophilic prostaglandin analog designed to interact with prostaglandin receptors. This compound exhibits biological activity related to modulation of vascular tone and smooth muscle contraction. It serves as a valuable tool in research applications focused on cardiovascular function and reproductive biology, enabling the investigation of prostaglandin signaling pathways and their implications in various physiological processes. -
AR Antagonist
(+) -JJ-450 is a non-competitive antagonist of the androgen receptor (AR), effectively inhibiting AR nuclear localization and transcriptional activity in the absence of androgen. This compound promotes the degradation of unliganded AR within the nucleus, thereby reducing the binding of AR to androgen response elements (AREs), including its splice variants like ARv7. With lower efficacy than its counterpart, (-)-JJ-450, in suppressing prostate-specific antigen (PSA) expression in LN95 cells, (+)-JJ-450 is particularly relevant for research focused on castration-resistant prostate cancer (CRPC) that exhibits resistance to enzalutamide. -
Latanoprost Derivative
9-Keto-latanoprost is a derivative of the F-prostaglandin (FP) receptor agonist, Latanoprost. This compound exhibits significant biological activity by selectively activating FP receptors, which plays a crucial role in regulating intraocular pressure. 9-Keto-latanoprost is primarily utilized in research applications focused on glaucoma treatment and ocular pharmacology, providing insights into prostaglandin signaling pathways and their therapeutic implications. -
Prostaglandin Inhibitor
Ibuprofen guaiacol ester is a potent inhibitor of prostaglandin synthesis, demonstrating significant oral bioactivity. It is primarily utilized in research related to inflammation, edema, and fever modulation. This compound provides valuable insights into the mechanistic pathways of pain and inflammatory responses, making it a useful tool in pharmacological studies. -
Vasopressor
11-deoxy Prostaglandin F1α is a potent vasopressor compound that serves as an analog of prostaglandin F1α. This reagent demonstrates significant biological activity, including the stimulation of uterine contractions and bronchoconstriction. Its mechanisms make it valuable for research applications involving vascular function and respiratory responses. -
EP4 Agonist
CCI17464 is a selective, orally active EP4 partial agonist with a pKi of 7.1. This compound demonstrates significant biological activity in the modulation of inflammatory responses and has been effectively utilized in the Freund's complete adjuvant (FCA) acute rat inflammatory pain model. CCI17464 shows promise in the complete reversal of allergic reactions, making it a valuable tool for research in inflammation and allergic responses. -
Prostaglandin Receptor
AL 8810 isopropyl ester is a potent and selective antagonist of the FP receptor, functioning as an 11β-fluoro analog of prostaglandin F2α. This lipid-soluble, esterified prodrug form enhances the compound's bioavailability, making it suitable for research applications targeting ocular pharmacology and the modulation of intraocular pressure. AL 8810 isopropyl ester is designed for investigations related to prostaglandin receptor signaling pathways and therapeutic interventions in glaucoma treatment. -
Bimatoprost acid Derivative
17-Trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F2α is a derivative of Bimatoprost acid that primarily targets the prostaglandin EP receptor. This compound exhibits potent biological activity in promoting ocular hypotensive effects, making it relevant for studies on glaucoma and intraocular pressure regulation. Its unique fluorinated structure may also enhance binding affinity and selectivity, facilitating research in pharmacology and therapeutic development related to eye disorders. -
Prostacyclin Receptor Agonist
AFP-07 is a potent and selective agonist of the prostacyclin receptor (IP receptor), with a Ki value of 0.561 nM. This compound is utilized in research focusing on cardiovascular biology and inflammation, offering insights into prostacyclin-mediated signaling pathways. Its strong affinity makes it suitable for studying the therapeutic potential of prostacyclin analogs in various disease models. -
Cloprostol
(+)-5-trans Cloprostenol is a synthetic derivative of prostaglandin F2α, primarily targeting prostaglandin pathways. This compound is associated with various biological activities related to reproductive physiology and is commonly utilized in veterinary medicine for its role in managing reproductive disorders in cattle, pigs, and horses. As a secondary impurity produced during the synthesis of (+)-cloprostenol, its contribution to overall effects and applications in reproductive research should be considered. -
CRTh2 Antagonist
ARRY-502 is a potent and selective antagonist of the CRTh2 receptor, demonstrating oral bioavailability. By inhibiting PGD2-mediated Th2 inflammation, ARRY-502 effectively blocks eosinophil activation and airway hyperresponsiveness. This reagent holds significant potential for research applications focused on Th2-related asthma and related inflammatory disorders. -
Prostaglandin Analog
17-Phenyl trinor prostaglandin A2 is a synthetic analog of prostaglandin that primarily targets the prostaglandin pathway. This compound exhibits significant biological activity, influencing various physiological processes such as vasodilation and platelet aggregation. It is commonly utilized in research applications focusing on cardiovascular function, inflammation, and related signaling pathways. -
Latanoprost Metabolite
15-Keto latanoprost is a metabolite of latanoprost, primarily functioning as an ocular hypotensive agent. This compound is used extensively in research to investigate its effects on intraocular pressure and its mechanisms of action in glaucoma treatment. Its role as a biomarker and its influence on prostaglandin pathways make it a valuable tool for studying ocular pharmacology and therapeutic interventions in eye diseases. -
Isomer
5,6-trans-Bimatoprost is an isomer of Bimatoprost, primarily used as an experimental control in research. As a prostaglandin analogue, it plays a significant role in studies related to ocular hypertension and glaucoma. Additionally, 5,6-trans-Bimatoprost exhibits anti-adipogenic properties, making it relevant for investigations into fat formation and metabolic processes. -
TXA₂ Receptor Antagonist
ICI 185282 is a selective thromboxane A2 (TXA₂) receptor antagonist that exhibits potent, orally active inhibition. It effectively reduces U-46619-induced platelet aggregation in a dose-dependent manner in guinea pig models. Additionally, ICI 185282 demonstrates efficacy in preventing bronchospasm triggered by various inflammatory mediators such as PGD2, PGF2α, arachidonic acid, LTD4, and PAF in vivo. This compound is valuable for research in bronchial asthma and related respiratory conditions. -
Isomer
trans-Latanoprost acid is an isomer of Latanoprost acid, primarily targeting the reduction of intraocular pressure. This compound exhibits significant biological activity in studies focused on ocular diseases. It is predominantly utilized as an analytical standard for the detection and quantification of impurities in pharmaceutical formulations. -
EP2 Receptor Agonist
Evatanepag sodium is a potent and selective agonist of the EP2 receptor, functioning as a non-prostanoid compound. This reagent has been shown to induce local bone formation in vivo, making it valuable for research into fractures and bone defects. Additionally, Evatanepag sodium is applicable in studies related to asthma, providing insights into its potential therapeutic effects in respiratory conditions. -
Platelet Aggregation Inhibitor
17-Phenyl-18,19,20-trinor-PGD2 is a potent inhibitor of platelet aggregation that primarily targets adenosine diphosphate (ADP) signaling pathways. It demonstrates an IC50 of 8.4 μM, significantly outperforming prostaglandin D2 (PGD2), which has an IC50 of 18.6 nM. Additionally, 17-Phenyl-18,19,20-trinor-PGD2 serves as a weak agonist for cyclic AMP accumulation, making it a valuable tool for research in cardiovascular and hemostatic studies. -
Prostaglandin Analog
Prostaglandin E1 alcohol is a prostaglandin analog that functions as a potent vasodilator. It is known to enhance blood flow and has applications in research related to cardiovascular diseases and tissue perfusion. This compound is also utilized in studies exploring its effects on smooth muscle relaxation and receptor signaling pathways. -
EP1 Antagonist
GSK345931A is an EP1 receptor antagonist that demonstrates significant central nervous system penetration in murine models. It exhibits potent analgesic effects in both acute and sub-chronic inflammatory pain models, making it a valuable tool for exploring pain mechanisms and potential therapeutic applications in pain management research. -
DP2 Antagonist
MK-1029 is a potent DP2 antagonist that selectively inhibits the D-type prostaglandin receptor. This compound exhibits significant activity in modulating inflammatory responses and bronchoconstriction, making it a valuable tool for investigating respiratory diseases such as asthma. Its ability to block DP2 signaling pathways aids in understanding the underlying mechanisms of chronic airway diseases and evaluating potential therapeutic strategies. -
Antifertility Compound
L-10503 is a non-hormonal antifertility compound that operates through a unique mechanism distinct from traditional prostaglandin-based strategies. This compound exhibits significant inhibitory effects on reproductive processes, making it valuable for studying fertility regulation and contraceptive research. Its application extends to investigations of non-hormonal contraceptive methods and understanding the mechanisms underlying fertility. -
Isomer
(R)-L 888607 is the isomer of L 888607, serving as a valuable experimental control. As a potent and selective agonist of the CRTH2 receptor, it demonstrates high affinity, with a Ki value of 4 nM. This compound has applications in studying various physiological events and metabolites, providing insights into immune response modulation and related pathways. Its oral bioavailability further facilitates in vivo research applications. -
Aipogenic Agent
AD 4743 is an adipogenic agent with the primary mechanism of inducing the accumulation of FPRP and lipid droplets in cells. It has demonstrated the ability to inhibit the proliferation of preadipose cells, making it a valuable tool for research in adipogenesis and metabolic studies. This compound can be used to investigate the mechanisms of adipocyte differentiation and related metabolic processes. -
Prostaglandin Receptor Agonist
Irodanoprost is a potent agonist of prostaglandin receptors, playing a significant role in mediating osteogenesis. Its primary mechanism involves stimulating bone formation and remodeling, making it valuable for research into osteogenesis-related diseases. This compound is useful for studying the effects of prostaglandin signaling in various bone-related conditions. -
Stereoisomer
16(R)-Iloprost is a stereoisomer of the potent vasodilator Iloprost, primarily targeting the prostacyclin receptor. This compound demonstrates significant biological activity by inhibiting platelet aggregation, with an IC50 value of 65 nM. It is utilized in research applications involving cardiovascular studies and the exploration of thrombotic disorders. -
Prostacyclin Analog
(Rac)-Beraprost is an orally active prostacyclin analog that exerts its effects by binding to prostacyclin membrane receptors, which inhibits the release of Ca2+ from intracellular stores. This mechanism promotes smooth muscle cell relaxation and vasodilation. With notable vasodilatory, antiplatelet, and cytoprotective properties, (Rac)-Beraprost is a valuable reagent for research focused on cardiovascular conditions, including thromboangiitis obliterans and atherosclerosis. -
Bronchodilator
11-Deoxy prostaglandin E1 is a synthetic analog of prostaglandin E1 that functions primarily as a bronchodilator. It effectively inhibits histamine-induced bronchoconstriction and induces relaxation in tracheal strips from isolated guinea pigs. This compound is valuable for research applications focusing on respiratory physiology and the modulation of airway reactivity. -
CRTh2 Receptor Antagonist
NVP-QAV680 is a selective antagonist of the CRTh2 receptor, exhibiting low nanomolar potency in inhibiting CRTh2-mediated activation of human eosinophils and Th2 lymphocytes. This compound demonstrates significant oral bioavailability and has shown efficacy in models of CRTh2-dependent mechanisms and allergic diseases in rats. Its properties make NVP-QAV680 a valuable tool for research in allergy and immunology. -
FP Receptor Antagonist
AL 8810 methyl ester is a competitive antagonist of the prostaglandin F(2α) receptor (FP receptor). It effectively inhibits the biological activity of the FP receptor agonist Fluprostenol, allowing for detailed studies of FP receptor-mediated pathways. This compound does not exhibit significant potency against other prostaglandin receptor subtypes, including TP, DP, EP(2), and EP(4), making it a valuable tool for specific FP receptor research applications. -
Prostaglandin Metabolism Inhibitor
L11204 is a potent inhibitor of prostaglandin metabolism. It effectively inhibits PMS-induced superovulation, resulting in a reduced number of recoverable ova in the oviducts of hamsters. Additionally, L11204 demonstrates the capability to inhibit chorionic gonadotrophin-induced ovarian hypertrophy and steroidogenesis in rats. This compound shows promise for studying reproductive system disorders and related biological processes. -
Isoprostaglandin
15-A2t-Isoprostane is an isoprostaglandin formed through the non-enzymatic oxidation of arachidonic acid. This compound serves as a significant biomarker for oxidative stress and lipid peroxidation in biological systems. Its biological activities include the modulation of inflammation and vascular function, making it valuable for research in cardiovascular diseases and oxidative stress-related pathologies. -
Aromatase Activator
5-trans-PGE2 is a potent aromatase activator that serves a crucial role in the paracrine signaling pathway between epithelial cells and adjacent stromal cells. By enhancing the activity of aromatase, it influences estrogen biosynthesis, which is fundamental in the context of breast cancer growth and development. This compound is particularly valuable for research applications focused on hormone regulation and cancer biology. -
8-iso Prostaglandin E2 Derivative
8-Iso Prostaglandin E2 isopropyl ester is a derivative of 8-iso Prostaglandin E2, designed to enhance lipophilicity compared to its free acid counterpart. This compound exhibits significant biological activity, primarily functioning as a modulator of various signaling pathways involved in inflammation and cellular responses. It is commonly utilized in research applications to investigate the roles of prostaglandins in physiological and pathological processes. -
EP4 Antagonist
(R)-Vorbipiprant is a selective antagonist of the prostaglandin E2 receptor 4 (EP4), exhibiting a binding affinity (Ki) of 16.6 nM for human EP4. It effectively inhibits PGE2-induced cAMP production, with an IC50 value of 22 nM. This compound demonstrates significant immunomodulatory and anti-angiogenic properties, making it a valuable tool for research in inflammation and arthritis, particularly in models of collagen-induced arthritis in mice. -
Prostaglandin Receptor Inhibitor
1,2,3-Trilinoelaidoyl glycerol acts as a prostaglandin receptor inhibitor, influencing the biosynthesis of prostaglandins and modulating platelet function. This compound also demonstrates significant effects on the fatty acid composition within rat organs, depending on the dosage administered. It serves as a valuable tool for examining dietary impacts on lipid metabolism and associated physiological parameters in preclinical research involving rodent models. -
Thromboxane Synthase Inhibitor
Furegrelate is a selective thromboxane synthase inhibitor that acts primarily by blocking the synthesis of thromboxane A2 (TxA2) in human platelets, exhibiting an IC50 of 15 nM. Its potent inhibitory action makes Furegrelate a valuable candidate for research applications focused on antiplatelet therapies. This compound is under investigation for its potential to mitigate thrombotic events associated with cardiovascular diseases. -
FP Antagonist
TGI-15 is a highly selective antagonist of the prostaglandin F receptor (FP). By inhibiting the binding of PGF2α to FP receptors, TGI-15 disrupts downstream signaling pathways, making it a valuable tool for investigating fibrotic and inflammatory conditions. This compound is essential for research focused on the modulation of inflammation and fibrosis. -
Anti-bronchospasm Agent
16,16-Dimethylprostaglandin F2β is a synthetic analog of prostaglandin F2β with a primary action as an anti-bronchospasm agent. This compound effectively prevents bronchospasm induced by various irritants, making it valuable in respiratory research. Its ability to modulate bronchial smooth muscle responsiveness supports its application in studies related to asthma and other obstructive airway diseases. -
EP1 Prostaglandin Receptor Antagonist
EP1 receptor antagonist-1 is an antagonist of the EP1 prostaglandin receptor, which plays a critical role in mediating inflammatory responses. This compound demonstrates significant biological activity by inhibiting EP1 receptor signaling, making it valuable for research focused on urinary system-related diseases. Its potential applications include investigating pathways involved in urinary tract conditions and assessing therapeutic strategies targeting prostaglandin receptors. -
PGF2α Analogue
(+)-Cloprostenol sodium is a selective agonist of the prostaglandin F2α (PGF2α) receptor. It exhibits key biological activities such as promoting smooth muscle contraction and modulating uterine activity, making it valuable in reproductive research. This compound is typically employed in studies related to veterinary medicine and endocrinology, particularly in the regulation of reproductive processes.
