ICI 185282 is a selective thromboxane A2 (TXA₂) receptor antagonist that exhibits potent, orally active inhibition. It effectively reduces U-46619-induced platelet aggregation in a dose-dependent manner in guinea pig models. Additionally, ICI 185282 demonstrates efficacy in preventing bronchospasm triggered by various inflammatory mediators such as PGD2, PGF2α, arachidonic acid, LTD4, and PAF in vivo. This compound is valuable for research in bronchial asthma and related respiratory conditions.
ICI 185282 is a selective thromboxane A2 (TXA₂) receptor antagonist that exhibits potent, orally active inhibition. It effectively reduces U-46619-induced platelet aggregation in a dose-dependent manner in guinea pig models. Additionally, ICI 185282 demonstrates efficacy in preventing bronchospasm triggered by various inflammatory mediators such as PGD2, PGF2α, arachidonic acid, LTD4, and PAF in vivo. This compound is valuable for research in bronchial asthma and related respiratory conditions.
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