Fig. 1 · Structure
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NVP-QAV680
CRTh2 Receptor Antagonist
NVP-QAV680 is a selective antagonist of the CRTh2 receptor, exhibiting low nanomolar potency in inhibiting CRTh2-mediated activation of human eosinophils and Th2 lymphocytes. This compound demonstrates significant oral bioavailability and has shown efficacy in models of CRTh2-dependent mechanisms and allergic diseases in rats. Its properties make NVP-QAV680 a valuable tool for research in allergy and immunology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 872365-16-7 |
| Applications | CRTh2 Receptor Antagonist |
| Formula | C18H18N2O4S |
| Molecular Weight | 358.41 |
| SMILES | O=C(O)CC1=C(C)N(CC2=CC=C(S(=O)(C)=O)C=C2)C3=NC=CC=C31 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.