Catalog No.
Product Name
Application
Product Information
Citations
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Prostaglandin 2 Isosteric Analogue
11-Deoxy-11-methylene PGD2 is a chemically stable isosteric analogue of Prostaglandin D2, featuring an exocyclic methylene group in place of the 11-keto group. This compound has been shown to significantly stimulate fat storage, even in the presence of Indomethacin, highlighting its potential role in lipid metabolism research. It is a valuable tool for investigating the effects of prostaglandin analogues on adipogenesis and other metabolic processes. -
Prostaglandin Receptor Control
15(R)-15-Methyl prostaglandin F2α methyl ester is a 15-methyl substituted prostaglandin analog that acts primarily on prostaglandin receptors. This compound exhibits potential biological activities, including modulation of smooth muscle contraction and vascular responses. Its applications extend to reproductive biology, where it may assist in understanding mechanisms of labor induction and regulation of uterine dynamics. -
TXA2/Prostaglandin Receptor Antagonist
L-670596 is a selective thromboxane A2 receptor and prostaglandin receptor antagonist. This compound effectively inhibits bronchoconstriction induced by arachidonic acid and U-44069 in guinea pig models. Additionally, L-670596 reduces platelet aggregation triggered by U-44069 in human platelet-rich plasma, making it a valuable reagent for studies in cardiovascular and respiratory physiology. -
EP4 Receptor Antagonist
ER-819762 is a selective antagonist of the prostaglandin E2 (PGE2) EP4 receptor, demonstrating an EC50 value of 70 nM in human EP4 receptor assays. This compound is primarily employed in research related to rheumatoid arthritis, making it a valuable tool for investigating the role of EP4 signaling in inflammatory processes and potential therapeutic interventions. -
EP2 Receptor Agonist
ONO-8815Ly is a selective agonist of the EP2 receptor. It demonstrates the ability to inhibit spontaneous uterine contractility, making it a valuable tool for investigating mechanisms related to uterine dynamics. This compound is useful in research applications focused on reproductive biology and potential therapeutic avenues for uterine disorders. -
Prostaglandin Receptor Inhibitor
15(S)-Latanoprost is a potent agonist of prostaglandin receptors, exhibiting reduced activity compared to its parent compound, latanoprost. In a binding assay utilizing cat iris sphincter muscle, 15(S)-latanoprost demonstrated an IC50 value of 24 nM. Furthermore, administration of 3 μg of 15(S)-latanoprost resulted in a measurable decrease in intraocular pressure (IOP) by 1 mmHg in normotensive cynomolgus monkeys. This compound is valuable for research into ocular conditions and the modulation of intraocular pressure. -
Thromboxane Synthetase Inhibitor
Dazmegrel is a thromboxane synthetase inhibitor that effectively reduces the synthesis of Thromboxane A2 (TXA2), demonstrating antiplatelet and vasodilator properties. This compound is valuable in research focused on thrombosis and the modulation of platelet aggregation, making it a useful tool for studying cardiovascular diseases and related therapeutic interventions. -
EP1 Antagonist
GSK-269984B is a potent antagonist of the EP1 receptor, a key target in modulating prostaglandin signaling pathways. This compound exhibits significant anti-inflammatory properties and is primarily utilized in research related to inflammatory pain mechanisms. Its ability to inhibit EP1 receptor activity makes it a valuable tool for exploring therapeutic strategies in pain management and related conditions. -
PGI2 Analog
6α-Prostaglandin I1 is an analogue of prostacyclin I2 (PGI2) that exhibits enhanced stability in aqueous environments due to its resistance to hydrolysis. This compound primarily targets the prostacyclin receptor, playing a crucial role in mediating anti-inflammatory and vasodilatory effects. It is utilized in research applications focusing on cardiovascular health, vascular biology, and the investigation of prostaglandin pathways. -
TXA₂ Modulator
BM-573 is an orally active dual thromboxane A₂ (TXA₂) modulator that functions through specific inhibition of thromboxane synthase (TxAS) and antagonism of thromboxane receptors (TP). With an IC50 of 1.3 nM, it effectively inhibits platelet aggregation induced by arachidonic acid or TXA₂ analogues without affecting cyclooxygenase enzymes (COX-1/COX-2), thus preserving other prostaglandin syntheses. BM-573 also demonstrates a significant inhibitory effect on U-46619-induced contractions in rat gastric fundus smooth muscle. This compound is valuable for research applications in atherosclerosis, myocardial infarction, pulmonary hypertension, and shock. -
Prostaglandin Receptor Control
Alprostadil sodium is a ligand for prostaglandin receptors, demonstrating Ki values of 36, 10, 1.1, 2.1, and 33 nM for the EP1, EP2, EP3, EP4, and IP receptors in murine models, respectively. This compound effectively promotes vasodilation and inhibits platelet aggregation, rendering it a valuable tool for research into peripheral vascular disease and its associated pathophysiology. Alprostadil sodium's vasodilatory properties make it significant for exploring therapeutic strategies in vascular disorders. -
Prostaglandin Receptor
Latanoprost lactone diol is an intermediate in the synthesis of Latanoprost, a potent prostaglandin F2α analogue that acts as an agonist at the FP prostanoid receptor. This compound exhibits key biological activity in lowering intraocular pressure (IOP) and is extensively utilized in research focused on glaucoma treatment and ocular hypertension. Its role in prostaglandin receptor interactions makes it valuable for studying related therapeutic applications. -
Bcl-2 Modulator, PCNA Modulator, Oxidative Stress Inducer
Proquinazid is a Bcl-2 and PCNA modulator that acts as an oxidative stress inducer. It is known to induce genotoxic effects and promote apoptosis by influencing the balance of pro-apoptotic and anti-apoptotic proteins. This compound is utilized in research applications focusing on cellular responses to DNA damage and apoptosis mechanisms. -
EP2 Receptor Agonist
EP2 receptor agonist 4 is a selective agonist targeting the EP2 receptor, exhibiting an EC50 of 43 nM. This compound is instrumental in studying the roles of EP2 receptor activation in various biological processes, including inflammation and pain modulation. Its specificity allows for detailed investigations into the receptor's function and potential therapeutic applications in related diseases. -
PGD2 Antagonist
S-5751 is an orally active antagonist of the prostaglandin D2 (PGD2) receptor. It effectively inhibits cAMP generation in platelet-rich plasma induced by PGD2 with an IC50 of 0.12 μM. S-5751 demonstrates anti-inflammatory properties and is particularly useful in asthma research, providing insights into the modulation of inflammatory pathways. -
Bronchoconstrictor
16,16-Dimethylprostaglandin F2α is a potent bronchoconstrictor and a stable analog of prostaglandin F2α. It exhibits comparable binding affinity to PGF2α, facilitating studies on its biological activity and mechanisms of action. This compound is commonly utilized in research related to respiratory physiology and pharmacological assessments of bronchial constriction. -
Endogenous Hormone
Prostaglandin D2-1-glyceryl ester is a bioactive lipid mediator that serves as an endogenous hormone. It plays a critical role in various physiological processes, including regulation of inflammation and modulation of immune responses. This compound is utilized in research applications focused on the study of prostaglandin signaling pathways and their implications in cardiovascular and neuroinflammatory diseases. -
Thromboxane Antagonist
L 655240 is a potent thromboxane antagonist that plays a crucial role in modulating cardiovascular responses. It has been demonstrated to reduce early ischemia and reperfusion-induced arrhythmias in canine models of coronary artery occlusion. Additionally, L 655240 is being investigated for its potential applications in cancer and autoimmune disorders, highlighting its importance in diverse areas of biomedical research. -
EP2-Receptor Agonist
AH13205 is a selective agonist of the prostanoid EP2 receptor. It elicites concentration-dependent relaxations in Carbachol-contracted trachea, demonstrating its potential as a bronchodilator. Additionally, AH13205 provides dose-dependent protection against Histamine-induced increases in respiratory rate, indicating its utility in respiratory research applications. -
TxA2 Antagonist
L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, exhibiting high selectivity and potency. The compound consists of two enantiomers: (-)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid, with an IC50 of 0.27 nM, and (+)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid, with an IC50 of 124 nM. L-657926 is utilized in research focused on thromboxane signaling pathways, cardiovascular disease studies, and the modulation of related biological processes. -
Dinoprost Metabolite
Tetranor-PGFM is a primary urinary metabolite of Dinoprost, serving as an important biochemical marker. It plays a crucial role in the monitoring of prostaglandin F biosynthesis and is utilized in research related to reproductive biology and inflammation. Tetranor-PGFM can provide insights into prostaglandin metabolism and the physiological effects associated with its regulation. -
EP1/EP3 Receptor Agonist
19(R)-Hydroxy prostaglandin E1 is an agonist of the EP1 and EP3 receptor subtypes. This compound is primarily involved in smooth muscle contractility, making it significant in studies related to reproductive biology and smooth muscle physiology. Its biological activity supports research into various physiological and pathological processes influenced by prostaglandins. -
Cyclopentenone Analog
Prostaglandin A1 methyl ester is a cyclopentenone analog that functions primarily as a modulator of inflammatory processes. It exhibits significant biological activity as an inducer of apoptosis and a potent anti-inflammatory agent. This compound is widely used in research applications focused on inflammation, cancer biology, and the study of prostaglandin pathways. -
Prostaglandin E1 Analogue
Rioprostil is a potent prostaglandin E1 analogue, primarily targeting the regulation of gastric acid secretion. It exhibits significant antisecretory effects, along with anti-gastric lesion properties, making it valuable for studies focused on mucosal protection. This compound serves as an important reagent in gastrointestinal research, particularly in understanding the mechanisms underlying gastric mucosal defense. -
IP Agonists
FK-788 is a potent PGI(2) and IP receptor agonist, exhibiting significant anti-aggregation activity with an IC50 of 18 nM. It demonstrates a high binding affinity for the human recombinant IP receptor, characterized by a Ki value of 20 nM. This compound is valuable for research applications focused on studying platelet aggregation and vascular function. -
PGF1α Metabolite
13,14-Dihydro-15-keto PGF1α is a metabolite of PGF1α that acts as a potent agonist of the prostaglandin F receptor. This compound plays a significant role in the regulation of various physiological processes, including vasodilation and smooth muscle contraction. It is particularly useful in biochemical research for studying the effects of prostaglandins on cellular functions and their implications in cardiovascular and reproductive biology. -
EP3 Receptor Antagonist
EP3 antagonist 2 is a potent and selective antagonist of the EP3 receptor, exhibiting a strong binding affinity with a Ki value of 3.3 nM. This compound demonstrates significant antagonistic activity, with an IC50 of 30.8 nM, as determined by its ability to modulate cellular cAMP levels. EP3 antagonist 2 is suitable for research applications exploring the physiological roles of the EP3 receptor in various biological processes and potential therapeutic interventions. -
TXA2 Synthase/TP-Receptor Inhibitor
ICI D1542 is a selective and potent inhibitor of thromboxane A2 (TXA2) synthase and the thromboxane A2 receptor (TP receptor). It exhibits significant biological activity in preventing thrombus formation by modulating arachidonic acid metabolism. ICI D1542 is utilized in research applications focused on cardiovascular diseases and thrombotic disorders, providing insights into the role of TXA2 in vascular biology. -
Thromboxane Receptor Agonist
AGN 191976 is a selective agonist of the thromboxane A2 (TP) receptor, exhibiting EC50 values of 0.23 nM in rat aorta and 24 nM in human platelets. This compound demonstrates significant intraocular pressure-lowering effects in canine and primate models. AGN 191976 serves as a valuable tool for investigating vascular biology and elucidating the role of thromboxane A2 in vascular function and related pathophysiological processes. -
PGF2α Analogue
16-Phenoxy prostaglandin F2α ethyl amide is a metabolically stable analogue of PGF2α, featuring an ethyl amide moiety that enhances its stability. This compound exhibits key biological activities, including the modulation of smooth muscle contraction and potential roles in reproductive health research. It is valuable for studies focused on prostaglandin signaling pathways and their implications in various physiological and pathological processes. -
Prostaglandin Receptor Inhibitor
Ciproquazone is a prostaglandin receptor inhibitor that effectively reduces prostaglandin biosynthesis. It exhibits a relative inhibitory potency that falls between indomethacin and aspirin, making it a relevant tool for research in inflammatory processes. Its reversible mode of action allows for precise modulation in experimental settings, facilitating studies in pain management and related pharmacological applications. -
PGF2α Receptor Activator
(Rac)-SC-31391 is a potent activator of the PGF2α receptor. This prostaglandin analog enhances bladder muscle contractility, significantly augmenting twitch responses in the guinea pig detrusor muscle. In human bladder muscle, (Rac)-SC-31391 induces contractions through selective PGF2α receptor activation, making it valuable for research into bladder function and related disorders. -
Prostaglandin Receptor
19(R)-hydroxy Prostaglandin E2 is a selective agonist targeting the prostaglandin EP2 receptor. Known for its potent smooth muscle relaxant properties, it demonstrates an EC50 value of 200 nM in relaxing cat tracheal rings that express EP2 receptors. This compound is valuable for research applications focused on smooth muscle physiology and prostaglandin signaling pathways. -
Prostacyclin Analogue
Ciprostene is a prostacyclin analogue that primarily targets the prostacyclin receptor. It effectively inhibits adenosine diphosphate-induced platelet aggregation, making it a valuable reagent for research on cardiovascular disorders. This compound is particularly useful in studies related to peripheral vascular disease and thrombosis. -
Tafluprost Derivative
9-Keto tafluprost is a derivative of tafluprost, which functions as an agonist of prostaglandin receptors. This compound exhibits significant activity in lowering intraocular pressure, making it relevant in the study and treatment of glaucoma. It is utilized in research exploring the pharmacological effects of prostaglandin analogs and their mechanisms in ocular conditions. -
Prostaglandin D2 Prodrug
Prostaglandin D2 methyl ester is a prodrug of Prostaglandin D2, primarily targeting the PGD2 receptors. It exhibits binding affinities (Ki values) of 160 nM for murine CRTH2, 175 nM for murine DP, 460 nM for human CRTH2, and 270 nM for human DP. This compound is useful in research applications investigating inflammatory responses, allergic reactions, and sleep regulation, highlighting its importance in pharmacological studies related to prostaglandin signaling pathways. -
Anti-arrhythmias Drug
Ro 22-9194 is an anti-arrhythmic agent that inhibits thromboxane A2 (TXA2) synthetase activity, affecting platelet aggregation in both rabbit and human models. This compound demonstrates significant efficacy in suppressing various types of model arrhythmias. Additionally, Ro 22-9194 possesses non-cholinergic cardiac depressant properties, complemented by its vasodilatory effects, making it valuable for cardiovascular research applications. -
TXA2 Antagonist
L 657925 is a potent thromboxane A2 (TXA2) antagonist, selectively inhibiting TXA2-mediated signaling pathways. This compound effectively abolishes the ONO 11113-induced transient increase in intracellular calcium concentration, making it a valuable tool for studying TXA2-related physiological processes. Its application spans research into cardiovascular diseases and platelet function, contributing to a deeper understanding of thromboxane's role in vascular biology. -
Prostaglandin Analogue
17-Trifluoromethylphenyl-13,14-dihydro trinor prostaglandin F1α is a saturated prostaglandin analogue that targets the human prostaglandin F receptor (hFP receptor). It exhibits a notable affinity and selectivity for this receptor, demonstrating an EC50 value of 85 nM. This compound is useful in research applications focused on prostaglandin signaling pathways and the development of therapeutics targeting reproductive functions and vascular biology. -
Prostaglandin Receptor
ONO 207 is a potent analog of Prostaglandin F2α, specifically designed to target prostaglandin receptors. It demonstrates enhanced luteolytic activity in hamsters, exhibiting a potency five times greater than that of PGF2α. With an ED50 value of 1.5 μg/100 g, ONO 207 is a valuable reagent for studying reproductive physiology and luteolysis in various biological research contexts. -
TX Synthetase Inhibitor
LG 82-4-01 is a selective thromboxane (TX) synthetase inhibitor, exhibiting an IC50 of 1.3 μM. This compound effectively inhibits the synthesis of thromboxanes, which are implicated in various cardiovascular and inflammatory processes. LG 82-4-01 is useful in studying TX-mediated pathways and assessing potential therapeutic interventions in related diseases. -
Prostaglandin F2α Analogue
16-Phenoxy tetranor Prostaglandin F2α methyl ester is a metabolically stable analogue of Prostaglandin F2α, designed to bind selectively to the FP receptor. This compound functions as a prodrug that can be hydrolyzed to release its bioactive free acid form, enabling its use in various biological assays. Its properties make it suitable for research applications focused on reproductive physiology and other areas involving prostaglandin signaling. -
PGD1 analog
Prostaglandin D1 alcohol is a synthetic analog of Prostaglandin D1 (PGD1) featuring a primary alcohol substitution at the C-1 position. This compound maintains the biological properties of PGD1, engaging the prostaglandin receptors to exhibit various physiological effects. It is utilized in molecular research related to inflammation, vascular biology, and neuroprotection, aiding in the study of prostaglandin-mediated signaling pathways. -
Analog of Prostacyclin
Prostaglandin K1 is a structural analog of prostacyclin, primarily acting on the EP1 receptor. It exhibits an EC50 of 2800 nM and a Ki of 2800 nM, indicating its affinity for this target. This compound serves as a valuable tool in research focused on prostanoid signaling pathways and their implications in various physiological and pathological processes. -
Prostaglandin Receptor
9-keto Fluprostenol is an analog of prostaglandin E2 (PGE2) designed to target the prostaglandin receptor with enhanced potency and prolonged half-life. This compound, an oxidation derivative of fluprostenol, acts primarily on the FP receptor and is expected to exhibit significant affinity for EP receptors, functioning as a PGE2 agonist. It holds potential for research applications related to inflammation, reproductive biology, and other physiological processes mediated by prostaglandins. -
Fluprostenol Analog
Fluprostenol methyl ester is an F-series prostaglandin analog primarily targeting the prostaglandin receptors. It demonstrates luteolytic activity and is utilized extensively in veterinary medicine for reproductive management. This compound is essential for research applications focused on reproductive physiology and the regulation of the estrous cycle in animals. -
Prodrug
Prostaglandin E1 ethyl ester is a prodrug of Prostaglandin E1 (PGE1), a potent ligand for prostaglandin receptors. This compound is known for its ability to induce vasodilation and inhibit platelet aggregation, making it valuable in vascular research. It is utilized in studies related to cardiology, reproductive health, and conditions of impaired blood flow. -
Prostaglandin FP Agonist
AR-102 isopropyl ester is a second-generation prostaglandin FP agonist that targets the FP receptor to effectively lower intraocular pressure. This compound exhibits potent biological activity in research applications related to glaucoma and ocular hypertension, making it a valuable tool for studying therapeutic interventions in these conditions. Its specific mechanism of action supports the exploration of novel treatments aimed at managing elevated ocular pressure. -
Prostaglandin E2 Inhibitor
Camonagrel is a potent inhibitor of Prostaglandin E2, targeting thromboxane synthase to decrease the biosynthesis of thromboxane. This compound exhibits significant anti-inflammatory properties and is useful in research applications focused on cardiovascular disease and inflammation pathways. Its inhibition of Prostaglandin E2 makes it a valuable reagent for studies investigating platelet aggregation and vascular function. -
FP Receptor Inhibitor
CAY10509 is a potent inhibitor of the FP receptor, characterized by an IC50 value of 30 nM. As a PGF2α analog, it serves as a valuable tool for investigating physiological regulatory mechanisms associated with prostaglandin signaling. This reagent is suitable for applications in pharmacological studies and the exploration of inflammatory processes in various biological systems.
