AGN 191976 is a selective agonist of the thromboxane A2 (TP) receptor, exhibiting EC50 values of 0.23 nM in rat aorta and 24 nM in human platelets. This compound demonstrates significant intraocular pressure-lowering effects in canine and primate models. AGN 191976 serves as a valuable tool for investigating vascular biology and elucidating the role of thromboxane A2 in vascular function and related pathophysiological processes.
AGN 191976 is a selective agonist of the thromboxane A2 (TP) receptor, exhibiting EC50 values of 0.23 nM in rat aorta and 24 nM in human platelets. This compound demonstrates significant intraocular pressure-lowering effects in canine and primate models. AGN 191976 serves as a valuable tool for investigating vascular biology and elucidating the role of thromboxane A2 in vascular function and related pathophysiological processes.
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