L 657925

Catalog No.: A63388
TXA2 Antagonist
L 657925 is a potent thromboxane A2 (TXA2) antagonist, selectively inhibiting TXA2-mediated signaling pathways. This compound effectively abolishes the ONO 11113-induced transient increase in intracellular calcium concentration, making it a valuable tool for studying TXA2-related physiological processes. Its application spans research into cardiovascular diseases and platelet function, contributing to a deeper understanding of thromboxane's role in vascular biology.
Grouped product items
Size Price Stock Qty
25mg
$1,275.00
In stock
50mg
$1,625.00
In stock
100mg
$2,000.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionL 657925 is a potent thromboxane A2 (TXA2) antagonist, selectively inhibiting TXA2-mediated signaling pathways. This compound effectively abolishes the ONO 11113-induced transient increase in intracellular calcium concentration, making it a valuable tool for studying TXA2-related physiological processes. Its application spans research into cardiovascular diseases and platelet function, contributing to a deeper understanding of thromboxane's role in vascular biology.
Product Information
Catalog NumA63388
FormulaC21H21ClFNO2
Molecular Weight373.85
CAS Number122757-59-9
SMILESFC1=CC=C(N(C2([H])C3([H])CCCC2CC(O)=O)CC4=CC=C(C=C4)Cl)C3=C1
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